Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin

Abstract

There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.

The invention claimed is: 
     
       1. A method for reversing or mitigating skin aging, comprising:
 a) topically applying on a patient's skin a composition comprising at least one oxidant, at least one photoactivator that is a fluorescent dye capable of activating the oxidant and at least one healing factor selected from hyaluronic acid, glucosamine and allantoin; and 
 b) exposing said composition to actinic light having an emission wavelength between about 400 nm and about 600 nm for a time sufficient to activate said oxidant; 
 wherein the method reverses or mitigates skin aging. 
 
     
     
       2. The method according to  claim 1 , wherein the oxidant is selected from hydrogen peroxide, carbamide peroxide and benzoyl peroxide. 
     
     
       3. The method according to  claim 1 , which further comprises at least one hydrophilic gelling agent. 
     
     
       4. The method according to  claim 1 , which further comprises at least one chelating agent selected from ethylenediaminetetraacetic acid (EDTA) and ethylene glycol tetraacetic acid (EGTA). 
     
     
       5. The method according to  claim 1 , which further comprises at least one lipolysis stimulating factor selected from caffeine and paraxanthine. 
     
     
       6. The method according to  claim 1 , wherein the at least one photoactivator is eosin Y. 
     
     
       7. The method according to  claim 1 , wherein the at least one photoactivator is selected from a xanthene derivative dye, an azo dye, a biological stain and a carotenoid. 
     
     
       8. The method according to  claim 6 , wherein the composition comprises at least one additional photoactivator selected from phloxine B, rose bengal, eosin B, fluorescein, erythrosine B, rhodamine B, rhodamine G, rhodamine WT, saffron red powder, annatto extract, brown algae extract, saffranin O, basic fuchsin, acid fuschin, 3,3′ dihexylocarbocyanine iodide, carminic acid, indocyanine green, crocetin, α-crocin (8,8-diapo-8,8-carotenoic acid), merbromine, zeaxanthine, lycopene, α-carotene, β-carotene, bixin, fucoxanthine, methyl violet, neutral red, para red, amaranth, carmoisine, allura red AC, tartrazine, orange G, ponceau 4R, methyl red, murexide-ammonium purpurate, pyronine Y and pyronine B. 
     
     
       9. The method according to  claim 1 , wherein the composition is exposed to the actinic light for about 60 seconds to 5 minutes, or about 60 seconds to 5 minutes per cm 2  of treatment area.