Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases

Abstract

One embodiment of the present invention is a pharmaceutical composition comprising at least one specific 2-iminopyrrolidine derivative and at least one other compound (B). Another embodiment of the present invention is a pharmaceutical composition comprising at least one specific 2-iminopyrrolidine derivative, which is to be used in combination with at least one other compound (B). According to the present invention, there are provided pharmaceutical compositions capable of treating or ameliorating diseases, such as heart diseases, effectively.

What is claimed is: 
     
       1. A method of treating or ameliorating atherothrombosis, wherein said method comprises: administering to a patient in need thereof an effective amount of a compound of formula (I), or a pharmacologically acceptable salt thereof, 
       
         
           
           
               
               
           
         
         and an effective amount of aspirin, 
       
       wherein said effective amount of the compound of formula (I) is from about 50 mg to about 400 mg and
 wherein said effective amount of aspirin is from about 0.1 to about 10-fold (weight ratio) the effective amount of the compound of formula (I), or its pharmacologically acceptable salt. 
 
     
     
       2. The method according to  claim 1 , wherein a hydrobromide salt of the compound of formula (I) is administered. 
     
     
       3. The method according to  claim 1 , wherein the effective amount of aspirin is about 80 mg to about 350 mg.