US8680271B2ActiveUtilityA1

Process for synthesizing 6-bromo-3-1-(1-methyl-1H-pyrazol-4-yl)-5-(3(R)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine

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Individually held — no corporate assignee on recordPriority: Mar 26, 2010Filed: Mar 21, 2011Granted: Mar 25, 2014
Est. expiryMar 26, 2030(~3.6 yrs left)· nominal 20-yr term from priority
Inventors:Melodie Deniz ChristensenJungchul Kim
C07D 487/04
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PatentIndex Score
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Cited by
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References
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Claims

Abstract

A process for the preparation of the compound of Formula (I) is described.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A process for preparing the compound of Formula I 
       
         
           
           
               
               
           
         
       
       comprising:
 1) treating the compound of Formula A with alcoholic HCl for about 30 minutes-4 hrs at about 25-70° C.; 
 2) adjusting the pH to about 10-11 using KOH; 
 3) adding ethanol, and heating to a temperature of 50-80° C. for about 10-120 minutes; 
 4) cooling to below reflux; 
 5) optionally seeding with the compound of Formula I; and 
 6) isolating the compound of Formula I.

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