Process for synthesizing 6-bromo-3-1-(1-methyl-1H-pyrazol-4-yl)-5-(3(R)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine

Abstract

A process for the preparation of the compound of Formula (I) is described.

We claim: 
     
       1. A process for preparing the compound of Formula I 
       
         
           
           
               
               
           
         
       
       comprising:
 1) treating the compound of Formula A with alcoholic HCl for about 30 minutes-4 hrs at about 25-70° C.; 
 2) adjusting the pH to about 10-11 using KOH; 
 3) adding ethanol, and heating to a temperature of 50-80° C. for about 10-120 minutes; 
 4) cooling to below reflux; 
 5) optionally seeding with the compound of Formula I; and 
 6) isolating the compound of Formula I.