Odor suppression of volatile organic analgesic compounds and method of use

Abstract

Disclosed are odor suppressing analgesic compositions comprising: a) from about 0.1% to about 20%, by weight, of farnesol or other suitable deodorizing bacteriostatic agent; and b) from about 0.1% to about 60%, by weight, volatile organic compound wherein said volatile organic compound may be encapsulated and is chosen from the following (menthol, camphor, methyl salicylate, methyl nicotiniate, or combination of thereof); and c) a water-in-oil or oil-in-water emulsion, gel, patch, plaster, ointment, solution or spray carrier. An optimized odor suppressing analgesic composition can provide a combination of antimicrobial properties, odor suppression properties, skin cooling or heating properties, topical analgesic properties, low irritation and stability.

What is claimed is: 
     
       1. A odor suppressing composition comprising:
 a) from about 1.0% to 20%, by weight, of deodorizing bacteriostatic agent; 
 b) from about 1.25% to about 70%, by weight, of one or more volatile organic analgesics selected from the group of menthol, camphor, methyl salicylate, and combinations of thereof; 
 c) at least about 0.1% by weight of a neuro-sensorial ingredient, wherein said ingredient is selected from the group consisting of: a mixture of 4-t-butylcyclohexanol and pentylene glycol, bisabolol, ginger root extract and chamomile extract; and 
 d) a topical carrier. 
 
     
     
       2. The odor suppressing composition of  claim 1 , wherein said deodorizing bacteriostatic agent is selected from the group of farnesol, 2-methyl 5-cyclohexylpentanol, dimethyl phenyl 2-butanol and combinations thereof. 
     
     
       3. The odor suppressing composition of  claim 1 , wherein said deodorizing bacteriostatic agent comprises at least 1.5% by weight of farnesol. 
     
     
       4. The odor suppressing composition of  claim 1 , wherein at least a portion of said volatile organic analgesic is encapsulated with an encapsulate material. 
     
     
       5. The odor suppressing composition of  claim 4 , wherein the encapsulate material encapsulating the volatile organic analgesic compound is comprised of water, menthyl lactate, diisopropyl adipate, glyceryl stearate, ethoxydiglycol, glyceryl dilaurate, polysorbate 80, PEG-150 stearate, cetyl alcohol, soya sterol, phenoxythanol, methylparaben, glycerin, disodium EDTA, xanthan gum. 
     
     
       6. The odor suppressing composition of  claim 1 , wherein said topical carrier is selected from the group consisting of water-in-oil or oil-in-water emulsion, gel, patch, plaster, ointment, solution or spray. 
     
     
       7. The composition according to  claim 1 , wherein the composition has a viscosity of from about 10,000 to about 1,000,000 centipoise, and wherein the water is present in an amount from about 30% to 60%. 
     
     
       8. The composition according to  claim 1 , wherein the composition contains less than 10% ethanol. 
     
     
       9. The composition according to  claim 1 , wherein the composition has a vapor pressure of less than 8 kPa. 
     
     
       10. The composition according to  claim 1 , wherein the composition is substantially free of artificial preservatives. 
     
     
       11. The composition according to  claim 1 , wherein the composition is substantially free of parabens. 
     
     
       12. The composition according to  claim 1 , wherein the composition has a relatively low evaporation rate such that after being exposed for one hour at 25° C., less than 7% by weight of the volatile ingredients have evaporated. 
     
     
       13. The composition according to  claim 1 , wherein the composition is an anhydrous formulation in the form of a patch or an ointment. 
     
     
       14. The composition according to  claim 1 , wherein the neuro-sensorial ingredient of the composition comprises at least 0.25% by weight of a mixture of 4-t-butylcyclohexanol and pentylene glycol. 
     
     
       15. The composition according to  claim 7 , wherein the composition is in the form of a cream having at least 4% menthol and 2% farnesol. 
     
     
       16. The composition according to  claim 1 , wherein the composition further comprises oils and emulsifiers and solvents and is in the form of an emulsion created by forming a first phase containing oils and emulsifiers and mixing this with a second phase formed of solvents and volatile organic analgesics, and the deodorizing bacteriostatic agent is added to the composition after the emulsion has been created. 
     
     
       17. The composition according to  claim 16 , wherein the deodorizing bacteriostatic agent of the composition comprises farnesol in an amount of at least 2% by weight. 
     
     
       18. The composition according to  claim 1 , wherein the composition is in the form of a patch comprising a styrene-isoprene-styrene block co-polymer dough having menthol of at least 5% by weight as a volatile organic analgesic, farnesol in an amount of at least 2% by weight as a deodorizing bacteriostatic agent and no more than 10% by weight of ethanol. 
     
     
       19. The composition according to  claim 18 , wherein the composition has a vapor pressure of less than 8 kPa. 
     
     
       20. The composition according to  claim 1 , wherein the composition is in the form of a gel comprising a gelling agent, menthol of at least 5% by weight as a volatile organic analgesic, farnesol in an amount of at least 2% by weight as a deodorizing bacteriostatic agent and no more than 10% by weight of ethanol.