Method of determining dose and administration of statin

Abstract

The object of the present invention is to provide a method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease. The object is achieved by the method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease comprising Step (1) of measuring the intracellular SmgGDS expression level of a patient suffering from a cardiovascular disease before and after administration of statin; and Step (2) of determining the type and/or the dose of statin for the patient in reference to the SmgGDS expression level measured in the Step (1).

The invention claimed is: 
     
       1. A method of increasing the dose of a statin to a human patient suffering from a cardiovascular disease comprising:
 Step (1) measuring SmgGDS expression level in leukocytes of the patient suffering from a cardiovascular disease with the use of an anti SmgGDS antibody before administration of a statin; 
 Step (2) administering a statin to the patient; 
 Step (3) measuring SmgGDS expression level in leukocytes of the patient with the use of an anti SmgGDS antibody after administration of the statin; 
 Step (4) comparing the expression level measured in Step (1) to the expression level measured in Step (3) and detecting an SmgGDS expression level measured in Step (3) that is less than 1.4 times the SmgGDS expression level measured in Step (1); and 
 Step (5) administering a statin dose to the patient that is increased by 10 mg as compared to the statin administered in Step (2). 
 
     
     
       2. The method of increasing the dose of a statin according to  claim 1 , wherein the cardiovascular disease is cardiovascular hypertrophy, cardiomyocyte hypertrophy, cardiovascular fibrosis, coronary arteriosclerosis, hypertension or heart failure. 
     
     
       3. The method of increasing the dose of a statin according to  claim 1 , wherein the statin is selected from the group consisting of atorvastatin, dihydrocompactin, bervastatin, carvastatin, cerivastatin, crilvastatin, dalvastatin, fluvastatin, glenvastatin, fluindostatin, velostatin, lovastatin, mevastatin, compactin, pitavastatin, pravastatin, rivastatin, rosuvastatin, simvastatin, sirrivastatin, CI-981 and pharmacologically acceptable salts thereof. 
     
     
       4. The method of increasing the dose of a statin according to  claim 1 , wherein the cardiovascular disease is cardiovascular hypertrophy. 
     
     
       5. The method of increasing the dose of a statin according to  claim 1 , wherein the statin is atorvastatin.