US8772247B2ActiveUtilityPatentIndex 41
Anti-parasitic compounds
Est. expiryMar 20, 2029(~2.7 yrs left)· nominal 20-yr term from priority
A61K 38/08A61P 33/02C07K 7/06A61K 38/00A61K 31/555A61K 31/155A61K 31/185Y02A50/30A61P 33/00
41
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Cited by
4
References
4
Claims
Abstract
A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease.
Claims
exact text as granted — not AI-modifiedThe invention claimed is:
1. 1 An almiramide molecule, comprising a linear lipopeptide having the following structure
but specifically excluding compounds (1), (2) and (3)
wherein for (1), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R 4 consists of NH2:
and wherein for (2), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R 4 consists of NH2;
and wherein for (3), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R 4 consists of NH2, and further,
wherein R 1 is selected from one of the following moieties:
and wherein R 2 is selected from one of the following moieties: Me or H
and wherein R 3 is selected from one of the following moieties: Me or H
and wherein R 4 is selected from one of the following moieties: NH 2 , NMe 2 , OH, OMe.
2. An almiramide molecule, comprising a linear lipopeptide having the following structure
but specifically excluding compounds (1), (2) and (3)
wherein for (1), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R 4 consists of NH2:
and wherein for (2), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R 4 consists of NH2;
and wherein for (3), R 1 consists of
R 2 consists of Me, R 3 consists of H, and R4 consists of NH2, and further, wherein said almiramide molecule is selected from the group consisting of compounds 4, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 as shown below:
Comp.
R 1
R 2
R 3
R 4
4
Me
H
NH 2
11
Me
Me
NH 2
12
Me
Me
NMe 2
13
H
Me
NMe 2
14
H
Me
NMe 2
15
H
Me
NMe 2
16
H
Me
NMe 2
17
H
Me
OH
18
H
Me
OH
19
H
Me
OH
20
H
Me
OH
21
H
Me
OMe
22
H
Me
OMe
23
H
Me
OMe
24
H
Me
OMe.
3. The almiramide molecule of claim 2 comprising an N—N-dimethyl-amide C-terminus.
4. The almiramide molecule of claim 2 comprising at least one unsaturated terminus.Cited by (0)
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