Biomedical devices containing internal wetting agents

Abstract

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

What is claimed is: 
     
       1. A biomedical device formed from a reaction mixture comprising a high molecular weight hydrophilic polymer and an effective amount of an hydroxyl-functionalized silicone-containing monomer selected from the group consisting of bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane, 3-methacryloxy-2-(2-hydroxyethoxy)propyloxy)propylbis(trimethylsiloxy) methylsilane, N,N,N′,N′-tetrakis(3-methacryloxy-2-hydroxypropyl)-α,ω-bis-3-aminopropyl-polydimethylsiloxane, and hydroxyl-functionalized silicone containing monomers of formula: 
       
         
           
           
               
               
           
         
         where n=1-50 and R independently comprise H or a polymerizable unsaturated group, with at least one R comprising a polymerizable group, and at least one R comprising H. 
       
     
     
       2. The biomedical device of  claim 1  wherein the effective amount of said hydroxyl-functionalized silicone-containing monomer is about 5% to about 90%. 
     
     
       3. The biomedical device of  claim 1  wherein the device is a silicone hydrogel contact lens. 
     
     
       4. The biomedical device of  claim 1  comprising about 1% to about 15% high molecular weight hydrophilic polymer. 
     
     
       5. The biomedical device of  claim 2  wherein the effective amount of hydroxyl-functionalized silicone-containing monomer is about 10% to about 80%. 
     
     
       6. The biomedical device of  claim 1  wherein the effective amount of said hydroxyl-functionalized silicone-containing monomer is about 20% to about 50%. 
     
     
       7. The biomedical device of  claim 1  further comprising about 10% to about 40% additional silicone containing monomer, about 10% to about 50% hydrophilic monomers, and about 3% to about 15% high molecular weight hydrophilic polymer. 
     
     
       8. The biomedical device of  claim 7 , wherein the device is a soft contact lens. 
     
     
       9. The biomedical device of  claim 1 , wherein the hydroxyl-functionalized silicone-containing monomer has a monomer compatibility index of greater than about 0.5. 
     
     
       10. The biomedical device of  claim 1 , wherein the high molecular weight hydrophilic monomer is poly-N-vinylpyrrolidone. 
     
     
       11. A method of preparing a biomedical device comprising mixing a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized silicone-containing monomer to form a clear solution, and curing said solution.