Reaction cassette and assay device

Abstract

A reaction cassette for biochemical assay, a biochemical assay device including a first space configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward. A second space includes a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space and the second space are disposed such that when the reaction cassette is rotated allowing the liquid to drain into the second space. A third space is located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette is reversibly rotated allowing the liquid to drain into the third space, wherein an array of bumps is disposed in the third space to create turbulence of the liquid. An inner partition wall, connected with the second opening and the third opening, acts as a liquid flow channel between the second space and the third space.

The invention claimed is: 
     
       1. A reaction cassette for biochemical assay, comprising:
 a first space configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward; 
 a second space having a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space and the second space are disposed such that when the reaction cassette is rotated allowing the liquid to drain into the second space; 
 a third space located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette is reversibly rotated allowing the liquid to drain into the third space, wherein an array of bumps is disposed in the third space to create turbulence of the liquid; and 
 an inner partition wall, connected with the second opening and the third opening, acting as a liquid flow channel between the second space and the third space. 
 
     
     
       2. The reaction cassette according to  claim 1 , wherein the reaction cassette is made of optical grade transparent material. 
     
     
       3. The reaction cassette according to  claim 1 , wherein a slant plane is disposed between the second space and the third space such that the liquid is allowed to flow in smoothly. 
     
     
       4. The reaction cassette according to  claim 1 , further comprising an outer wall defining an inner space, wherein the first space, the second space, the third space, and the inner partition wall are disposed within the inner space, and the outer wall comprising an inlet located above the first space. 
     
     
       5. The reaction cassette according to  claim 3 , further comprising a protrusion connecting with the outer wall for preventing the reaction cassette from being placed into a measurement instrument in wrong directions. 
     
     
       6. The reaction cassette according to  claim 1 , further comprising a cover sealed on the outer wall and inner partition walls by supersonic sealing. 
     
     
       7. A biochemical assay device, comprising:
 a reaction cassette for biochemical assay, comprising: 
 a first space configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward; 
 a second space having a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space and the second space are disposed such that when the reaction cassette is rotated allowing the liquid to drain into the second space; 
 a third space located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette is reversibly rotated allowing the liquid to drain into the third space, wherein an array of bumps is disposed in the third space to create turbulence of the liquid; and 
 a first inner partition wall, connected with the second opening and the third opening, acting as a liquid flow channel between the second space and the third space; and 
 a sampling part configured to be coupled to the reaction cassette, comprising: 
 a sampling tube configured to draw a liquid sample; 
 an absorption compartment containing an absorption material inside thereof; and 
 a reservoir configured to store a liquid reagent. 
 
     
     
       8. The biochemical assay device according to  claim 7 , wherein the reaction cassette is made of optical grade transparent material. 
     
     
       9. The biochemical assay device according to  claim 7 , wherein a first slant plane is disposed between the second space and the third space such that the liquid is allowed to flow in smoothly. 
     
     
       10. The biochemical assay device according to  claim 9 , wherein a second slant plane is disposed between the third space and the absorption compartment such that the liquid is allowed to flow in smoothly. 
     
     
       11. The biochemical assay device according to  claim 7 , further comprising an outer wall defining an inner space, wherein the first space, the second space, the third space, and the inner partition wall are disposed within the inner space, and the outer wall comprising an inlet located above the first space. 
     
     
       12. The biochemical assay device according to  claim 11 , further comprising a protrusion connecting with the outer wall for preventing the reaction cassette from being placed into a measurement instrument in wrong directions. 
     
     
       13. The biochemical assay device according to  claim 7 , wherein the sampling part is inserted into the reaction cassette through inlets, and the reaction cassette further comprises:
 a second inner partition wall, connected with the third space, acting as a liquid flow channel between the third space and the absorption compartment; and 
 a third inner partition wall disposed to separate two sub-inlets to guide the sampling cartage into the reaction cassette. 
 
     
     
       14. The biochemical assay device according to  claim 7 , wherein the sampling part includes a pair of bumps on a surface of the absorption compartment and the third inner partition wall include an extended end stuck between the pair of bumps while the sampling part and the reaction cassette are assembled. 
     
     
       15. The biochemical assay device according to  claim 14 , further comprising guiding parts are disposed on the reservoir facilitating the sampling tube which is in align with the first space while the sampling part and the reaction cassette are assembled. 
     
     
       16. The biochemical assay device according to  claim 7 , wherein the reservoir of the sampling part is sealed with an aluminum foil, and the aluminum foil is removed during insertion of the sampling part into the reaction cassette. 
     
     
       17. The biochemical assay device according to  claim 13 , further comprising a bump disposed on a transverse beam beside the sampling tube acted as a barb to peel off the aluminum foil while the sampling part and the reaction cassette are assembled.