Methods and compositions to treat myocardial conditions

Abstract

Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

What is claimed is: 
     
       1. A method comprising:
 delivering a structurally reinforcing agent to a ventricle 
 wherein the structurally reinforcing agent comprises one or more solid material capable of increasing the compliance of the ventricle and comprises at least one of a surface component capable of reacting with another moiety and a property to recruit cells. 
 
     
     
       2. The method of  claim 1 , wherein delivering comprises delivering of a structurally reinforcing agent to an infarct region of the ventricle. 
     
     
       3. The method of  claim 2 , wherein the structurally reinforcing agent is capable of increasing the modulus of elasticity of the infarct region. 
     
     
       4. The method of  claim 2 , wherein delivering a structurally reinforcing agent to the infarct region of a ventricle comprises introducing the structurally procedure selected from at least one of minimally invasive such as sub-xiphoid, percutaneous (catheter based) or surgical approach such as open-chest procedure in conjunction with Coronary Bypass Graft (CABG). 
     
     
       5. The method of  claim 4 , wherein the percutaneous introduction of the structurally reinforcing agent into the ventricle comprises at least one of the following modes consisting of intracoronary infusion, intraventricular catheter, intravenous pressure perfusion, transvascular needle catheter, and retrograde venous perfusion. 
     
     
       6. The method of  claim 5 , wherein the dose comprises a solid plug of predetermined size and shape. 
     
     
       7. The method of  claim 6 , wherein the shape comprises at least one of a disk, a sphere or a rod. 
     
     
       8. The method of  claim 2 , wherein delivering a structurally reinforcing agent to an infarct region of the ventricle comprises delivering one or more doses of at least one solid material. 
     
     
       9. The method of  claim 1 , wherein the structurally reinforcing agent is capable of preventing thinning of the ventricle. 
     
     
       10. The method of  claim 1 , wherein the solid material comprises at least one material selected from the group consisting of an organic polymer, a silicone based polymer, a biodegradable polymer, a non-biodegradable polymer, a metal, and an engineered biomaterial. 
     
     
       11. The method of  claim 10 , wherein the solid polymer comprises an engineered biomaterial. 
     
     
       12. The method of  claim 11 , wherein the engineered biomaterial comprises porcine derived Small Intestine Sub-mucosa (SIS). 
     
     
       13. The method of  claim 1 , wherein the solid material comprises at least one of the following, a shape of a screw or a helix, one or more reservoirs and a structure including an anchor component. 
     
     
       14. The method of  claim 13 , wherein the anchoring appendage anchors the solid material to a site. 
     
     
       15. The method of  claim 1 , wherein the surface component comprises surface groups capable of interacting with endogenous molecules. 
     
     
       16. A method comprising:
 delivering a structurally reinforcing agent to a ventricle, 
 wherein the structurally reinforcing agent comprises one or more solid material capable of increasing the compliance of the ventricle, wherein the solid material comprises one or more reservoirs, the one or more reservoirs comprising a drug. 
 
     
     
       17. The method of  claim 16 , wherein the drug comprises a small molecule, peptides, proteins and gene products. 
     
     
       18. A method comprising:
 delivering a structurally reinforcing agent to a ventricle, 
 wherein the structurally reinforcing agent comprises one or more solid material capable of increasing the compliance of the ventricle, wherein at least one solid material comprises a solid material generated from a mixture selected from the group consisting of contrast agents, drugs, PLGA compounded with a Barium compound and growth factors. 
 
     
     
       19. A kit comprising:
 a delivery lumen; 
 at least one agent, delivered from the delivery lumen, 
 the at least one agent comprising a structurally reinforcing agent 
 wherein said structurally reinforcing agent comprises at least one solid material configured for delivery to a ventricle, wherein the at least one solid material comprises at least one of a surface component capable of reacting with another moiety and a property to recruit cells. 
 
     
     
       20. The kit of  claim 19 , further comprising a delivery device. 
     
     
       21. The kit of  claim 20 , wherein the delivery device comprises a catheter. 
     
     
       22. The kit of  claim 19 , further comprising one or more drugs. 
     
     
       23. The kit of  claim 19 , wherein the at least one solid material comprises an engineered biomaterial. 
     
     
       24. The kit of  claim 23 , wherein the engineered biomaterial comprises a porcine derived Small Intestine Sub-mucosa (SIS).