US8862220B2ActiveUtilityA1

Artifact cancellation in hybrid audio prostheses

46
Assignee: MED EL ELEKTROMED GERAETE GMBHPriority: Dec 11, 2008Filed: May 29, 2013Granted: Oct 14, 2014
Est. expiryDec 11, 2028(~2.4 yrs left)· nominal 20-yr term from priority
Inventors:Marek Polak
A61B 5/7217A61N 1/36039H04R 25/70A61B 5/388A61B 5/24A61N 1/36032A61B 5/04001
46
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Claims

Abstract

A system and method are described for determining an estimated neural response in a hybrid electric acoustic audio prosthesis. Target nerve tissue such as remaining hair cells and cochlear nerve tissue receive synchronized electric and acoustic stimulation signals which are recorded and processed to determine an artifact canceled estimated neural response.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method of determining an estimated neural response in a hybrid electric acoustic audio prosthesis comprising:
 recording a B response by target nerve tissue to an electric stimulus sequence without acoustic stimulation which includes:
 i. delivering to the target nerve tissue a first electric stimulus pulse P 1  without acoustic stimulation to elicit a corresponding action potential followed by a relative refractory period, and 
 ii. within the relative refractory period, delivering to the target nerve tissue a second electric stimulus pulse P 2  without acoustic stimulation; 
 
 recording an A response by the target nerve tissue to a hybrid electric acoustic stimulus sequence which includes:
 i. delivering to the target nerve tissue a first reference electric stimulus pulse P 7  corresponding to the first-second electric stimulus pulse P 2 , and 
 ii. delivering to the target nerve tissue an associated acoustic stimulation signal; 
 
 recording a C response by the target nerve tissue to delivery of a second reference electric stimulus pulse P 5  without acoustic stimulation corresponding to the first electric stimulus pulse P 1 ; 
 processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y=A−(B−C). 
 
     
     
       2. A method according to  claim 1 , wherein the acoustic stimulation signal is triggered by the second electric stimulus pulse P 2 . 
     
     
       3. A method according to  claim 1 , wherein the acoustic stimulation signal precedes the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       4. A method according to  claim 1 , wherein the acoustic stimulation signal follows the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       5. A method according to  claim 1 , wherein the electric stimulus pulses have substantially equal amplitudes. 
     
     
       6. A neural response measurement system comprising:
 a control interface module for determining an estimated neural response in a hybrid electric acoustic audio prosthesis based on: 
 recording a B response by target nerve tissue to an electric stimulus sequence without acoustic stimulation which includes:
 i. delivering to the target nerve tissue a first electric stimulus pulse P 1  without acoustic stimulation to elicit a corresponding action potential followed by a relative refractory period, and 
 ii. within the relative refractory period, delivering to the target nerve tissue a second electric stimulus pulse P 2  without acoustic stimulation; 
 
 recording an A response by the target nerve tissue to a hybrid electric acoustic stimulus sequence which includes:
 i. delivering to the target nerve tissue a first reference electric stimulus pulse P 7  corresponding to the second electric stimulus pulse P 2 , and 
 ii. delivering to the target nerve tissue an associated acoustic stimulation signal; 
 
 recording a C response by the target nerve tissue to delivery of a second reference electric stimulus pulse P 5  without acoustic stimulation corresponding to the first electric stimulus pulse P 1 ; 
 processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y=A−(B−C). 
 
     
     
       7. A system according to  claim 6 , wherein the acoustic stimulation signal is triggered by the second electric stimulus pulse P 2 . 
     
     
       8. A system according to  claim 6 , wherein the acoustic stimulation signal precedes the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       9. A system according to  claim 6 , wherein the acoustic stimulation signal follows the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       10. A system according to  claim 6 , wherein the electric stimulus pulses have substantially equal amplitudes. 
     
     
       11. A method of determining an estimated neural response in a hybrid electric acoustic audio prosthesis comprising:
 recording a B response by target nerve tissue to a an electric stimulus sequence without acoustic stimulation which includes:
 i. delivering to the target nerve tissue a first electric stimulus pulse P 1  without acoustic stimulation to elicit a corresponding action potential followed by a relative refractory period, and 
 ii. within the relative refractory period, delivering to the target nerve tissue a second electric stimulus pulse P 2  without acoustic stimulation; 
 
 recording an A response by the target nerve tissue to a hybrid electric acoustic stimulus sequence which includes:
 i. delivering a first reference electric stimulus pulse P 7  corresponding to the second electric stimulus pulse P 2 , and 
 ii. delivering to the target nerve tissue an associated acoustic stimulation signal; 
 
 recording a C response by the target nerve tissue to delivery of a second reference electric stimulus pulse P 5  without acoustic stimulation corresponding to the first electric stimulus pulse P 1 ; 
 recording an F response by the target nerve tissue to delivery of a pair of reference electric stimulus pulses P 8  and P 9  without acoustic stimulation associated with the first and second electric stimulus pulses P 1  and P 2 ; and 
 processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y=A−(B−C)−F. 
 
     
     
       12. A method according to  claim 11 , wherein the acoustic stimulation signal is triggered by the second electric stimulus pulse P 2 . 
     
     
       13. A method according to  claim 11 , wherein the acoustic stimulation signal precedes the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       14. A method according to  claim 11 , wherein the acoustic stimulation signal follows the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       15. A method according to  claim 11 , wherein the electric stimulus pulses have substantially equal amplitudes. 
     
     
       16. A neural response measurement system comprising:
 a control interface module for determining an estimated neural response in a hybrid electric acoustic audio prosthesis based on: 
 recording a B response by target nerve tissue to an electric stimulus sequence without acoustic stimulation which includes:
 i. delivering to the target nerve tissue a first electric stimulus pulse P 1  without acoustic stimulation to elicit a corresponding action potential followed by a relative refractory period, and 
 ii. within the relative refractory period, delivering to the target nerve tissue a second electric stimulus pulse P 2 ; 
 
 recording an A response by the target nerve tissue to a hybrid electric acoustic stimulus sequence which includes:
 i. delivering to the target nerve tissue a first reference electric stimulus pulse P 7  corresponding to the second electric stimulus pulse P 2 , and 
 ii. delivering to the target nerve tissue an associated acoustic stimulation signal; 
 
 recording a C response by the target nerve tissue to delivery of a second reference electric stimulus pulse P 5  without acoustic stimulation corresponding to the first electric stimulus pulse P 1 ; 
 recording an F response by the target nerve tissue to delivery of a pair of reference electric stimulus pulses P 8  and P 9  without acoustic stimulation associated with the first and second electric stimulus pulses P 1  and P 2 ; and 
 processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y=A−(B−C)−F. 
 
     
     
       17. A system according to  claim 16 , wherein the acoustic stimulation signal is triggered by the second electric stimulus pulse P 2 . 
     
     
       18. A system according to  claim 16 , wherein the acoustic stimulation signal precedes the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       19. A system according to  claim 16 , wherein the acoustic stimulation signal follows the second electric stimulus pulse P 2  or the first reference electric stimulus pulse P 7 . 
     
     
       20. A system according to  claim 16 , wherein the electric stimulus pulses have substantially equal amplitudes.

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