US8969352B2ActiveUtilityPatentIndex 91
Substituted 2-azabicycles and their use as orexin receptor modulators
Est. expiryMar 13, 2033(~6.7 yrs left)· nominal 20-yr term from priority
A61P 25/00C07D 413/14C07D 401/14C07D 417/14C07D 403/14A61K 31/506C07D 519/00A61K 31/444C07D 401/12C07D 405/14A61K 31/4439C07D 471/08A61K 31/4725C07D 513/04C07D 487/08A61K 31/497A61K 31/4709
91
PatentIndex Score
12
Cited by
59
References
40
Claims
Abstract
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2 is H, alkyl, alkoxy, or halo; Z is NH or O; R3 is H, alkyl, alkoxy, halo, or triazolyl; R4 is H or alkyl; or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring; R5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl; and n is 1 or 2. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
Claims
exact text as granted — not AI-modifiedWhat is claimed:
1. A compound of formula I
or an enantiomer or diastereomer thereof;
or a pharmaceutically acceptable salt thereof;
wherein
X is N or CR 1 ;
Y is N or CR 2 ;
R 1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazolyl, oxadiazolyl, or pyrazolyl;
R 2 is H, alkyl, alkoxy, or halo;
Z is NH or O;
R 3 is H, alkyl, alkoxy, halo, or triazolyl;
R 4 is H or alkyl;
or R 3 and R 4 , together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring;
R 5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl; and
n is 1 or 2.
2. The compound of claim 1 , wherein Z is NH.
3. The compound of claim 1 , wherein Z is O.
4. The compound of claim 1 , wherein X is CR 1 and Y is CR 2 .
5. The compound of claim 1 , wherein X is CR 1 and Y is N.
6. The compound of claim 1 , wherein X is N and Y is CR 2 .
7. The compound of claim 1 , wherein R 1 is alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxaolyl, oxadiazolyl, or pyrazolyl.
8. The compound of claim 7 , wherein R 1 is alkoxy, halo, triazolyl, or pyrimidinyl.
9. The compound of claim 7 , wherein pyrazolyl is methyl-pyrazolyl or dimethyl-pyrazolyl.
10. The compound of claim 7 , wherein oxadiazolyl is methyl-oxadiazolyl.
11. The compound of claim 1 or 6 , wherein R 2 is H.
12. The compound of claim 1 or 6 , wherein R 2 is alkyl.
13. The compound of claim 12 , wherein alkyl is —CH 3 .
14. The compound of claim 1 or 6 , wherein R 2 is alkoxy.
15. The compound of claim 1 or 6 , wherein R 2 is halo.
16. The compound of claim 15 , wherein halo is F.
17. The compound of claim 1 , wherein R 3 is H.
18. The compound of claim 1 , wherein R 3 is alkyl.
19. The compound of claim 1 , wherein R 3 is alkoxy.
20. The compound of claim 1 , wherein R 3 is halo.
21. The compound of claim 1 , wherein R 3 is triazolyl.
22. The compound of claim 1 , wherein R 4 is H.
23. The compound of claim 1 , wherein R 4 is alkyl.
24. The compound of claim 23 , wherein alkyl is —CH 3 .
25. The compound of claim 1 , wherein R 3 and R 4 together with the atoms to which they are attached, form a 6-membered aryl ring.
26. The compound of claim 1 , wherein R 3 and R 4 together with the atoms to which they are attached, form a 6-membered heteroaryl ring containing one N.
27. The compound of claim 1 , wherein R 3 and R 4 together with the atoms to which they are attached, form a 5-membered heteroaryl ring containing one N.
28. The compound of claim 1 , wherein R 5 is pyridyl, optionally substituted with halo or alkyl.
29. The compound of claim 28 , wherein alkyl is trihaloalkyl.
30. The compound of claim 28 , wherein R 5 is pyridyl optionally substituted with trifluoromethyl.
31. The compound of claim 1 , wherein R 5 is pyrazinyl, optionally substituted with halo or alkyl.
32. The compound of claim 31 , wherein alkyl is trihaloalkyl.
33. The compound of claim 31 , wherein R 5 is pyrazinyl optionally substituted with trifluoromethyl.
34. The compound of claim 1 , wherein R 5 is pyrimidinyl, optionally substituted with halo or alkyl.
35. The compound of claim 34 , wherein alkyl is trihaloalkyl.
36. The compound of claim 34 , wherein R 5 is pyrimidinyl optionally substituted with trifluoromethyl.
37. The compound of claim 1 , wherein n is 1.
38. The compound of claim 1 , wherein n is 2.
39. A compound selected from the group consisting of
Ex.
No.
Compound
Compound Name
1
(R/S)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(6-((5- (trifluoromethyl)pyrazin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
2
(R/S)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2-yl)(6-((5- (trifluoromethyl)pyrazin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
3
(R/S)-(3-ethoxyisoquinolin-4- yl)((5-(trifluoromethyl)pyrazin-2- yl)oxy)-2-azabicyclo[2.2.1]heptan- 2-yl)methanone
4
(R/S)-5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2-yl)(6-((5- (trifluoromethyl)pyrazin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
7
(R/S)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
8
(R/S)-(3-ethoxyisoquinolin-4- yl)(6-((5-(trifluoromethyl)pyridin- 2-yl)oxy)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
9
(R/S)-(5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2-yl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
10
(R/S)-(7-ethoxyquinolin-8-yl)(6- ((5-(trifluoromethyl)pyridin-2- yl)oxy)-2-azabicyclo[2.2.1]heptan- 2-yl)methanone
11
(R/S)-(3-fluoro-2-(pyrimidin-2- yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
12
(R/S)-(4-methoxy-2-(pyrimidin-2- yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
13
(R/S)-4-methoxy-2-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
14
(R/S)-(5-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
15
(R/S)-2-methoxy-6-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
16
(R/S)-(3-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
17
(R/S)-(3-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
18
(R/S)-(2-fluoro-6-(2H-1,2,3- triazol-2-yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
19
(R/S)-(5-fluoro-2-(pyrimidin-2- yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
20
(R/S)-(4-fluoro-2-(pyrimidin-2- yl)phenyl)(-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
21
(R/S)-(2-(4H-1,2,4-triazol-4- yl)phenyl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
22
(R/S)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2-yl)(6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
23
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1R,4S,6S)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
24
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
25
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
26
(4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
27
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
28
(5-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
29
(6-methyl-2-(2H-1,2,3-triazol-2- yl)pyridin-3-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
30
(3-(2H-1,2,3-triazol-2-yl)pyridin-2- yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
31
(3-fluoro-2- methoxyphenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
32
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
33
(3-fluoro-2-(1H-1,2,3-triazol-1- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
34
(6-methyl-2-(1H-1,2,3-triazol-1- yl)pyridin-3-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
35
(3-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
36
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
37
(3-ethoxy-6-methylpyridin-2- yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
38
(2-fluoro-6-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
39
(2-methoxy-6-(1H-pyrazol-5- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
40
(2-methoxy-6-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
41
(2-(1,4-dimethyl-1H-pyrazol-5- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
42
(1H-indol-7-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
43
(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
44
(4-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
45
(2-bromo-3- fluorophenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
46
(2-fluoro-6-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
47
((1S,4R,6R)-6-((5-bromopyridin-2- yl)oxy)-2-azabicyclo[2.2.1]heptan- 2-yl)(2-fluoro-6-(pyrimidin-2- yl)phenyl)methanone
48
((1S,4R,6R)-6-((5-bromopyridin-2- yl)oxy)-2-azabicyclo[2.2.1]heptan- 2-yl)(3-fluoro-2-(pyrimidin-2- yl)phenyl)methanone
49
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((5- bromopyridin-2-yl)oxy)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
50
((1S,4R,6R)-6-((5-bromopyridin-2- yl)oxy)-2-azabicyclo[2.2.1]heptan- 2-yl)(6-methyl-3-(2H-1,2,3-triazol- 2-yl)pyridin-2-yl)methanone
51
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4R,6R)-6-((3- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
52
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((3- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
53
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
54
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
55
(3-methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
56
(7-ethoxyquinolin-8- yl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
57
(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
58
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
59
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
60
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
61
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
62
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
63
(4-methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
64
(4-methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
65
(4-methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
66
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
67
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
68
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
69
(2-(3-methyl-1,2,4-oxadiazol-5- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
70
(3-fluoro-2-(3-methyl-1,2,4- oxadiazol-5- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone
71
(3-fluoro-2-(3-methyl-1,2,4- oxadiazol-5- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
72
(3-fluoro-2-(3-methyl-1,2,4- oxadiazol-5- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.1]heptan-2- yl)methanone
73
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.2]octan-2- yl)methanone
74
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrazin-2-yl)oxy)- 2-azabicyclo[2.2.2]octan-2- yl)methanone
75
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)oxy)-2-azabicyclo[2.2.2]octan- 2-yl)methanone
76
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2-yl)oxy)- 2-azabicyclo[2.2.2]octan-2- yl)methanone
77
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrazin-2-yl)oxy)- 2-azabicyclo[2.2.2]octan-2- yl)methanone
78
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)oxy)-2-azabicyclo[2.2.2]octan- 2-yl)methanone
79
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
80
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
81
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
82
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
83
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrazin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
84
(6-methyl-3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)((1S,4R,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.2]octan-2- yl)methanone
40. A pharmaceutical composition comprising a compound according to claim 1 and at least one pharmaceutically acceptable excipient.Cited by (0)
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