US8999705B2ActiveUtilityPatentIndex 61
Bifidobacterial gene sequences and their use
Est. expirySep 15, 2026(~0.2 yrs left)· nominal 20-yr term from priority
C12N 9/2471C12Y 302/01023C12P 19/04C12N 9/88C12N 9/90C12Y 302/01051A23V 2002/00C12N 9/24C12P 19/00C12N 9/18C12Y 301/01053C12Y 501/03009C12Y 403/03007C12Y 302/01018C12Y 302/01052A23C 9/206C12N 9/2402A61P 1/00A23L 33/40A23V 2200/3202A23V 2250/28A23L 1/296C12Y 402/01052
61
PatentIndex Score
2
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26
References
6
Claims
Abstract
This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. An isolated nucleic acid comprising a recombinant expression cassette comprising a promoter operably linked to a heterologous polynucleotide encoding a sialidase polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence encoded by SEQ ID NO:1.
2. The nucleic acid of claim 1 , wherein the polypeptide comprises the amino acid sequence encoded by SEQ ID NO:1.
3. An isolated host cell comprising the recombinant expression cassette of claim 1 .
4. The host cell of claim 3 , wherein the polypeptide comprises the amino acid sequence encoded by SEQ ID NO:1.
5. An expression vector comprising a promoter operably linked to a heterologous polynucleotide encoding a sialidase polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence encoded by SEQ ID NO:1.
6. The expression vector wherein the polypeptide comprises the amino acid sequence encoded by SEQ ID NO:1.Cited by (0)
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