Polymer precursors of radiolabeled compounds, and methods of making and using the same

Abstract

One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds.

We claim: 
     
       1. A method of synthesizing a radiolabeled benzamide on a solid support comprising:
 a) selecting a solid support comprising at least one compound attached to said solid support, wherein the compound is selected from the group consisting of:
 Poly-(4S,5S)-2-(5-{dibutyl[2-(4-vinylphenyl)ethyl]stannyl}-2,3-dihydrobenzofuran-7-yl)-3,4-dimethyl-5-phenyl-1,3-oxazolidine-co-divinylbenzene; 
 Poly-(4S,5S)-2-(4-{dibutyl[2-(3-vinylphenyl)ethyl]stannyl}phenyl)-3,4-dimethyl-5-phenyl-1,3-oxazolidine-co-divinylbenzene; and 
 Poly-(4S,5S)-2-(4-{dibutyl[2-(4-vinylphenyl)ethyl]stannyl}phenyl)-3,4-dimethyl-5-phenyl-1,3-oxazolidine-co-divinylbenzene; 
 
 b) reacting said compound with at least one acid to afford a benzoic acid moiety or a carboxylic acid moiety; 
 c) reacting said moiety of said compound attached to said solid support with at least one amine to afford a benzamide bound to a solid support; and 
 d) reacting said benzamide bound to said solid support with a radioisotope; and an oxidant selected from the group consisting of chloramine-T,N-chlorosuccinimide, tert-butylhydroperoxide, iodogen, iodobeads and meta-chloroperbenzoic acid; to yield said radiolabeled benzamide. 
 
     
     
       2. The method of  claim 1  wherein the radioisotope is selected from the group consisting of  18 F,  11 C,  76 Br,  123 I,  131 I and  125 I.