Hypoglycemic compounds

Abstract

The present invention relates to novel hypoglycemic compounds of formula (1) and pharmaceutically acceptable salts thereof. The invention relates to novel amino acid derivatives of the formula (1), wherein, A is amino acid B is peptide bond R-NH- wherein R is defined in the specification.

What is claimed is: 
     
       1. A compound of formula 1, 
       
         
           
           
               
               
           
         
       
       wherein, A is an amino acid selected from glycine, alanine, β-alanine, valine, histidine, serine, leucine, isoleucine, phenylalanine, methionine, tryptophan, lysine, glutamine, glutamic acid, proline, cysteine, tyrosine, arginine, asparagine, aspartic acid, or threonine;
 wherein R-NH- is selected from formulae 2 to 6: 
 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       2. The compound of  claim 1 , wherein R-NH- is formula 2, or a pharmaceutically acceptable salt thereof. 
     
     
       3. The compound of  claim 1 , wherein R-NH- is formula 3, or a pharmaceutically acceptable salt thereof. 
     
     
       4. The compound of  claim 1 , wherein R-NH- is formula 4, or a pharmaceutically acceptable salt thereof. 
     
     
       5. The compound of  claim 1 , wherein R-NH- is formula 5, or a pharmaceutically acceptable salt thereof. 
     
     
       6. The compound of  claim 1 , wherein R-NH- is formula 6, or a pharmaceutically acceptable salt thereof. 
     
     
       7. A compound selected from: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       8. A compound selected from: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof.