Method of enhancing transdermal absorption using a composition comprising POE octyl dodecyl ether and squalane

Abstract

An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.

The invention claimed is: 
     
       1. A method of transdermally administering an active ingredient, comprising:
 applying a lyotropic liquid crystal compounded with the active ingredient to a skin surface of a person in need of transdermal administration of the active ingredient, 
 wherein said lyotropic liquid crystal contains 15.026% by weight to 28% by weight of a surfactant and 5% by weight to 80% by weight of water, 
 wherein said active ingredient is a macromolecular substance having a molecular weight of not less than 1,000 daltons, 
 wherein said surfactant is polyoxyethylene octyl dodecyl ether, 
 wherein said lyotropic liquid crystal further contains 16.819% by weight to 25% by weight of squalane, 
 wherein said lyotropic liquid crystal further contains 1% by weight to 55% by weight of glycerol. 
 
     
     
       2. The method of  claim 1 , wherein said lyotropic liquid crystal further contains 0.01% by weight to 10% by weight of an auxiliary surfactant. 
     
     
       3. The method of  claim 2 , wherein said auxiliary surfactant is cholesterol. 
     
     
       4. The method of  claim 1 , wherein said active ingredient is at least one member selected from the group consisting of organic compound, peptide, protein, oligonucleotide, DNA and RNA. 
     
     
       5. The method of  claim 1 , wherein said macromolecular substance is a water-soluble substance. 
     
     
       6. The method of  claim 1 , wherein said active ingredient is included in the inside of fine particles of inorganic acid salt with divalent metal. 
     
     
       7. The method of  claim 1 , wherein said active ingredient is compounded in an amount of 0.01% by weight to 50% by weight to the lyotropic liquid crystal. 
     
     
       8. The method of  claim 1 , wherein the ratio of each component in the lyotropic liquid crystal is as follows:
 polyoxyethylene octyl dodecyl ether: 28% by weight, 
 squalane: 25% by weight, 
 water: 16% by weight, and 
 glycerol: 31% by weight. 
 
     
     
       9. The method of  claim 1 , wherein the ratio of each component in the lyotropic liquid crystal is as follows:
 polyoxyethylene octyl dodecyl ether: 15.026% by weight, 
 squalane: 16.819% by weight, 
 water: 15.860% by weight, and 
 glycerol: 38.897% by weight. 
 
     
     
       10. The method of  claim 1 , wherein said lyotropic liquid crystal contains 10% by weight to 60% by weight of water. 
     
     
       11. The method of  claim 1 , wherein said lyotropic liquid crystal contains 13% by weight to 50% by weight of water.