US9139560B2ExpiredUtilityA1

Substituted pyrazines as tubulin inhibitors

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Assignee: YM BIOSCIENCES AUSTRALIA PTYPriority: Dec 3, 2003Filed: Feb 28, 2014Granted: Sep 22, 2015
Est. expiryDec 3, 2023(expired)· nominal 20-yr term from priority
Inventors:Christopher J. BurnsAndrew Frederick WilksMichael Francis HarteHarrison SikanyikaEmmanuelle Fantino
A61P 9/10A61P 37/02A61P 43/00A61P 37/08A61P 9/14A61P 9/00A61P 39/00A61P 37/00A61P 37/06A61P 31/12A61P 31/00A61P 35/00A61P 29/00A61P 19/02A61P 17/04C07D 401/14C07D 401/12C07D 213/74C07D 253/07C07D 239/42C07D 241/20C07D 403/12Y02A50/30A61K 31/4965
73
PatentIndex Score
1
Cited by
173
References
3
Claims

Abstract

Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerization and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
     
     
       2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a least one compound according to  claim 1 . 
     
     
       3. A method of modulating microtubule polymerisation in a subject, said method comprising administering to the subject a therapeutically effective amount of at least one compound according to  claim 1 .

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