Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof

Abstract

There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.

What is claimed is: 
     
       1. A compound of formula (IV), or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein
 X 1  is NH; 
 
         X 2  is O; 
         X 3  is NH; 
         R 1  is —H; 
         R 2  is —C(O)R 5 ; and 
         R 5  is —C2-C22 alkenyl. 
       
     
     
       2. The compound of  claim 1 , wherein R 5  is —C16-C22 alkenyl. 
     
     
       3. A compound that is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       4. A method for treating colon cancer comprising administering to a subject in need thereof an effective amount of the compound as recited in  claim 3 , or a pharmaceutically acceptable salt thereof. 
     
     
       5. A method of inhibiting colon cancer tumor growth, inhibiting colon cancer tumor cell proliferation, or reducing colon cancer tumor growth, in vitro or in vivo, comprising contacting said tumor with an effective amount of at least one compound as recited in  claim 1 , or a pharmaceutically acceptable salt thereof. 
     
     
       6. A method of inhibiting colon cancer tumor growth, inhibiting colon cancer tumor cell proliferation, or reducing colon cancer tumor growth, in vitro or in vivo, comprising contacting said tumor with an effective amount of the compound as recited in  claim 3 , or a pharmaceutically acceptable salt thereof.