Liposome and personal care composition comprising thereof

Abstract

A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

What is claimed is: 
     
       1. A liposome comprising:
 a) a phospholipid; 
 b) a hydrophobic active selected from the group consisting of glycyrrhetinic acid, glycyrrhetinyl stearate, glycyrrhizinic acid, undecylenoyl phenylalanine, ascorbyl tetraisopalmitate, and combinations thereof; and 
 c) a hydrophilic adjuvant comprising a positively charged group, wherein the hydrophilic adjuvant ionically bonds with the hydrophobic active to form a complex with said hydrophobic active and wherein the molar ratio of said hydrophobic active to said hydrophilic adjuvant is from about 1:10 to about 10:1. 
 
     
     
       2. The liposome of  claim 1  wherein said hydrophilic adjuvant is a basic amino acid selected from the group consisting of lysine, arginine, histidine and combinations thereof. 
     
     
       3. The liposome of  claim 1  wherein said hydrophobic active is present in an amount of from about 1% to about 20% by weight of the phospholipid. 
     
     
       4. The liposome of  claim 1  wherein said hydrophilic adjuvant is present in an amount of from about 1% to about 20% by weight of the phospholipid. 
     
     
       5. The liposome of  claim 1  wherein said phospholid is a hydrogenated phospholipid. 
     
     
       6. The liposome of  claim 1  further comprising an elasticity enhancer selection from the group consisting of a nonionic surfactant, polyoxyethylene cholesteryl ether, and combinations thereof. 
     
     
       7. The liposome of  claim 6  wherein said nonionic surfactant is polysorbate 80 or sorbitan monooleate. 
     
     
       8. The liposome of  claim 6  wherein said polyoxyethylene cholesteryl ether is C 27 H 45 O(CH 2 CH 2 O) n H, wherein n is from 5 to 15. 
     
     
       9. The liposome of  claim 1  further comprising an antioxidant selected from the group consisting of vitamin E, vitamin E ester, vitamin C, vitamin C ester and combinations thereof. 
     
     
       10. An aqueous liposome dispersion comprising the liposome of  claim 1 , wherein the phospholipid is present in an amount of from about 1% to about 20% by weight of said aqueous solution. 
     
     
       11. The aqueous liposome dispersion of  claim 10 , wherein an elasticity enhancer is present in an amount of from about 0.01% to about 10% by weight of said aqueous dispersion. 
     
     
       12. The aqueous liposome dispersion of  claim 10 , wherein the antioxidant is present in an amount of from about 0.01% to about 5% by weight of said aqueous dispersion. 
     
     
       13. A personal care composition comprising the liposome of  claim 1 , said personal care composition is in a form selected from the group consisting of creams, emulsions, gels, lotions, clear lotions, and combinations thereof. 
     
     
       14. A personal care composition made by using the aqueous liposome of  claim 10 , said personal care composition is in a form selected from the group consisting of creams, emulsions, gels, lotions, clear lotions, and combinations thereof.