US9416106B2ActiveUtilityA1

2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors

93
Assignee: UNIV NORTHWESTERNPriority: Mar 7, 2013Filed: Aug 31, 2015Granted: Aug 16, 2016
Est. expiryMar 7, 2033(~6.7 yrs left)· nominal 20-yr term from priority
C07D 401/14C07D 401/12C07D 213/73
93
PatentIndex Score
6
Cited by
10
References
6
Claims

Abstract

Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A compound selected from compounds of a formula 
       
         
           
           
               
               
           
         
       
       wherein R 1  is selected from 6-aminopyridin-2-yl and 6-amino-4-methylpyridin-2-yl moieties; X is selected from CH 2 O, CH 2 CH 2  and CH 2 OCH 2  moieties; Y is selected from O and CH 2  moieties; and n is an integer selected from 1 and 2, and salts thereof. 
     
     
       2. The compound of  claim 1  wherein R 1  is a 6-amino-4-methylpyridin-2-yl moiety. 
     
     
       3. The compound of  claim 2  wherein X is selected from CH 2 O and CH 2 OCH 2  moieties. 
     
     
       4. The compound of  claim 2  wherein n is 1. 
     
     
       5. The compound of  claim 1  wherein said compound is an ammonium salt. 
     
     
       6. The compound of  claim 4  wherein said ammonium salt has a counter ion that is a conjugate base of a protic acid.

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