Dialysis composition comprising citrate, calcium and magnesium

Abstract

Dialysis fluid compositions including 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium. These dialysis fluid compositions include 0.10 to 0.2 mM more total calcium per 1 mM citrate within the dialysis fluid as compared to the calcium concentration ordinarily prescribed for a non-citrate containing dialysis fluid.

The invention claimed is: 
     
       1. A dialysis composition comprising 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium, wherein the dialysis composition comprises [cit] mM citrate and [Ca] new  mM total calcium, wherein
   [Ca] new =[Ca] norm +( k   Ca ·[cit]),
 
 and wherein k ca  is within range of 0.10 to 0.2. 
 
     
     
       2. The dialysis composition according to  claim 1 , wherein
 [Ca] norm  is within the range of 1 to 5 mM and 
 k ca  is within range of 0.10 to 0.2. 
 
     
     
       3. The dialysis composition according to  claim 1 , wherein
 [Ca] norm  equals one of 1.00 mM, 1.25 mM, 1.5 mM, and 1.75 mM calcium, and 
 k ca  is within range of 0.10 to 0.2. 
 
     
     
       4. The dialysis composition according to  claim 1 , wherein
 [Ca] norm  equals at least one of 1.25 mM calcium and 1.5 mM calcium, and 
 k ca  is within range of 0.12 to 0.18. 
 
     
     
       5. The dialysis composition according to  claim 1 , wherein the dialysis composition further comprises [Mg] new  mM total magnesium, wherein
   [Mg] new =[Mg] norm +( k   mg ·[cit]), and
 
 k Mg  is within range of 0.04 to 0.10. 
 
     
     
       6. The dialysis composition according to  claim 1 , wherein
 [Mg] norm  is in range of 0 to 1.5 mM, and 
 k Mg  is within range of 0.04 to 0.10. 
 
     
     
       7. The dialysis composition according to  claim 1 , wherein
 [Mg] norm  is in range of 0.5 to 1.5 mM, and 
 k Mg  is within range of 0.04 to 0.10. 
 
     
     
       8. The dialysis composition according to  claim 1 , wherein
 [Mg] norm  equals at least one of 0.50 mM, 0.60 and 0.75 mM magnesium, and 
 k Mg  is within range of 0.04 to 0.10. 
 
     
     
       9. A method to form a dialysis composition comprising:
 determining for a patient a prescribed calcium concentration for a dialysis fluid to be administered to the patient, wherein the determination is made based on a non-citrate containing calcium dialysis fluid; 
 introducing 0.5 to 3 mM citrate to the dialysis fluid, 
 introducing 1 to 5 mM total calcium to the dialysis fluid, wherein the total calcium results in a calcium concentration 0.1 to 0.2 mM per 1 mM citrate greater than the prescribed calcium concentration; and 
 introducing 0 to 1.5 mM total magnesium to the dialysis fluid. 
 
     
     
       10. The method of  claim 9  wherein the determination of the prescribed calcium concentration determines the prescribed calcium concentration to be one of 1.00 mM, 1.25 mM, 1.50 mM, and 1.75 mM. 
     
     
       11. The method of  claim 9  wherein the determination of the prescribed calcium concentration is based on at least one of calcium concentration and calcium mass transport for the patient. 
     
     
       12. The method of  claim 9  further comprising:
 determining a prescribed concentration of total magnesium for the dialysis fluid, and 
 the introduction of the total magnesium results in a concentration of magnesium that is 0.04 to 0.10 mM per 1 mM citrate in the dialysis fluid greater than the prescribed concentration of total magnesium. 
 
     
     
       13. The method of  claim 12  wherein the determination of the prescribed magnesium concentration determines the prescribed magnesium concentration to be one of 0.50 mM, 0.6 mM, and 0.75 mM.