US9481649B2ActiveUtilityA1

Synthesis of a neurostimulative piperazine

45
Assignee: NEURALSTEM INCPriority: Aug 24, 2009Filed: Dec 9, 2015Granted: Nov 1, 2016
Est. expiryAug 24, 2029(~3.1 yrs left)· nominal 20-yr term from priority
Inventors:Sripathy VenkatramanSyed MahmoodBingidimi Itute MobeleOlga Viktorovna LapinaKellie VercoeYing LiJonathan SalsburyMark Mclaws
A61P 25/18A61P 25/28A61P 25/00C07D 213/82C07D 213/74C07D 401/12A61K 31/496
45
PatentIndex Score
0
Cited by
13
References
1
Claims

Abstract

The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method to convert a compound of formula (1): 
       
         
           
           
               
               
           
         
         wherein R 1  is isoamyl to a phosphate salt by reacting said compound with phosphoric acid wherein the reaction occurs in a solvent mixture consisting of ethanol and water.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.