Melampomagnolide B derivatives

Abstract

The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB. These derivatives are useful for treating cancer in humans.

What is claimed is: 
     
       1. A compound comprising Formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 R is selected from the group consisting of 
 
       
       
         
           
           
               
               
           
         
         wherein:
 R 1  is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, and substituted aromatic derivatives; 
 R 2  is selected from the group consisting of substituted indoles; and 
 R 3  is selected from the group consisting of substituted amines. 
 
       
     
     
       2. The compound of  claim 1 , wherein Formula (I) comprises: 
       
         
           
           
               
               
           
         
         wherein:
 X is selected from the group consisting of S, O, NH, NR 10 ; 
 R 9  is selected from the group consisting of OMe, Cl, Br and F; and 
 R 10  is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl. 
 
       
     
     
       3. The compound of  claim 1 , wherein Formula (I) comprises: 
       
         
           
           
               
               
           
         
         wherein:
 R 11  is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl; and 
 R 12  and R 13  are independently selected from the group consisting of H, F, Cl, Br, OCH 3 , CN, CH 3 , NO 2  and COOCH 3 . 
 
       
     
     
       4. The compound of  claim 1 , wherein Formula (I) comprises: 
       
         
           
           
               
               
           
         
         wherein:
 R 14  is selected from the group consisting of 2-thiophenyl, 3-thiophenyl, 2-pyrazine, 3-pyrazine, 2-amino nicotinic acid, indole-3-acetic acid, indole-3-acrylic acid. 
 
       
     
     
       5. The compound of  claim 1 , wherein Formula (I) comprises: 
       
         
           
           
               
               
           
         
         wherein:
 R 15  is selected from the group consisting of: 
 
       
       
         
           
           
               
               
           
         
       
     
     
       6. The compound of  claim 1 , wherein Formula (I) comprises: 
       
         
           
           
               
               
           
         
         wherein:
 R 1  is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, aromatic and aliphatic derivatives. 
 
       
     
     
       7. A pharmaceutically acceptable salt comprising a compound of  claim 1 .