US9492419B2ExpiredUtilityA1

Method for treating crohn'S disease or ulcerative colitis by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain

77
Assignee: ENZO BIOCHEM INCPriority: Sep 22, 2003Filed: Apr 7, 2015Granted: Nov 15, 2016
Est. expirySep 22, 2023(expired)· nominal 20-yr term from priority
Inventors:Elazar RabbaniXiaofeng LiDakai LiuYazhou ZhangRichard JinRiddhi BhattacharyyaWei ChengJames J. Donegan
A61K 31/235A61K 38/00A61P 3/10A61K 31/535G01N 33/564G01N 33/5041G01N 33/5011G01N 2333/705G01N 33/92A61K 31/015A61K 31/538G01N 2800/24A61K 31/185A61K 31/192A61K 31/395
77
PatentIndex Score
1
Cited by
442
References
9
Claims

Abstract

The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method for treating Crohn's disease or ulcerative colitis, comprising:
 administering to a human patient having Crohn's disease or ulcerative colitis a therapeutically effective amount of a compound selected from the group consisting of: 
 
       
         
           
           
               
               
           
         
       
     
     
       2. The method of  claim 1 , wherein the human patient has Crohn's disease. 
     
     
       3. The method of  claim 1 , wherein the human patient has ulcerative colitis. 
     
     
       4. The method of  claim 2 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
       5. The method of  claim 2 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
       6. The method of  claim 2 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
       7. The method of  claim 3 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
       8. The method of  claim 3 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
       9. The method of  claim 3 , Wherein the compound is

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.