Compound for promoting apoptosis of cancer cells and a pharmaceutical composition containing the same and uses thereof

Abstract

The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C 1 -C 20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.

The invention claimed is: 
     
       1. A compound of Formula (I) and a salt thereof, 
       
         
           
           
               
               
           
         
         wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C 1 -C 20  alkyl. 
       
     
     
       2. The compound of  claim 1 , wherein m is 2 and R is C 1 -C 13  alkyl. 
     
     
       3. A pharmaceutical composition, comprising the compound of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       4. A method for treating a cancer in a subject, comprising a step of administrating an effective amount of the pharmaceutical composition of  claim 3  to the subject, wherein the cancer is at least one selected from the group consisting of lung cancer, rectal cancer and bladder cancer. 
     
     
       5. The method of  claim 4 , wherein the pharmaceutical composition treats the cancer by suppressing the activity of EGFR protein kinase. 
     
     
       6. The method of  claim 4 , wherein the pharmaceutical composition treats the cancer by promoting an apoptosis of a cancer cell of the cancer and inhibiting a growth of the cancer cell.