Alkylamidothiazoles, cosmetic or dermatological preparations containing said alkylamidothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin

Abstract

Alkylamidothiazoles of general formula (I), wherein R 1=—C1-C24 alkyl (linear and branched), —C1-C24 alkenyl (linear and branched), —C1-C8 cycloalkyl, —C1-C8 cycloalkyl-alkylhydroxy, —C1-C24 alkylhydroxy (linear and branched), —C1-C24 alkylamine (linear and branched), —C1-C24 alkylaryl (linear and branched), —C1-C24 alkylaryl-alkyl-hydroxy (linear and branched), —C1-C24 alkyl-heteroaryl (linear and branched), —C1-C24-alkyl-O—C1-C24-alkyl (linear and branched), —C1-C24 alkyl morpholino, —C1-C24 alkyl piperidino, —C1-C24 alkyl piperazino, —C1-C24 alkyl-piperazino-N-alkyl, as well as cosmetic or dermatological preparations having an effective content of one or more alkylamidothiazoles, as well as the use thereof for the cosmetic or dermatological treatment and/or prophylaxis of undesired skin pigmentation.

The invention claimed is: 
     
       1. An alkylamidothiazole selected from the group consisting of 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       either as a free base or a cosmetically and dermatologically acceptable salt thereof. 
     
     
       2. An alkylamidothiazole of  claim 1 , wherein the alkylamidothiazole is present as a salt in the form of a halide, carbonate, ascorbate, sulfate, acetate or phosphate. 
     
     
       3. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       4. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramide. 
     
     
       5. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide. 
     
     
       6. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide. 
     
     
       7. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamide. 
     
     
       8. An alkylamidothiazole of  claim 1 , namely N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-hydroxymethyl)phenyl)acetamide. 
     
     
       9. A cosmetic or dermatological composition, wherein the composition comprises at least one alkylamidothiazole of  claim 1  and a cosmetic or dermatological carrier. 
     
     
       10. The composition of  claim 9 , wherein the composition comprises from 0.000001% to 10% by weight of the at least one alkylamidothiazole, based on a total weight of the preparation. 
     
     
       11. The composition of  claim 10 , wherein the composition comprises from 0.0001% to 3% by weight of the at least one alkylamidothiazole. 
     
     
       12. The composition of  claim 10 , wherein the composition comprises from 0.001% to 1% by weight of the at least one alkylamidothiazole. 
     
     
       13. The composition of  claim 9 , wherein the composition comprises at east N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       14. The composition of  claim 10 , wherein the composition comprises at least N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       15. The composition of  claim 11 , wherein the composition comprises at least N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       16. The composition of  claim 12 , wherein the composition comprises at least N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       17. A method for the cosmetic or dermatological treatment of undesired skin pigmentation in a subject in need thereof, wherein the method comprises applying to skin affected by the undesired skin pigmentation the composition of  claim 9  in an amount which is sufficient to treat the undesired skin pigmentation. 
     
     
       18. A method for the prophylaxis of undesired skin pigmentation, wherein the method comprises applying to skin the composition of  claim 9  in an amount which is sufficient to prevent undesired skin pigmentation. 
     
     
       19. The method of  claim 17 , wherein the composition comprises at least N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide. 
     
     
       20. The method of  claim 18 , wherein the composition comprises at least N-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide.