Method to form a dialysis composition comprising citrate, calcium and magnesium

Abstract

A method to form a dialysis composition includes determining for a patient a prescribed calcium concentration for a dialysis fluid to be administered to the patient. The determination is made based on a non-citrate containing calcium dialysis fluid. 0.5 to 3 mM citrate and 1 to 5 mM total calcium are introduced to the dialysis fluid. The total calcium results in a calcium concentration that is 0.1 to 0.2 mM per 1 mM citrate greater than the prescribed calcium concentration. 0 to 1.5 mM total magnesium is introduced to the dialysis fluid.

The invention is claimed as follows: 
     
       1. A method to form a dialysis composition, the method comprising:
 determining for a patient a prescribed calcium concentration for a dialysis fluid to be administered to the patient, wherein the determination is made based on a non-citrate containing calcium dialysis fluid; 
 introducing 0.5 to 3 mM citrate to the dialysis fluid, 
 introducing 1 to 5 mM total calcium to the dialysis fluid, wherein the total calcium results in a calcium concentration that is 0.1 to 0.2 mM per 1 mM citrate greater than the prescribed calcium concentration; and 
 introducing 0 to 1.5 mM total magnesium to the dialysis fluid. 
 
     
     
       2. The method of  claim 1 , wherein the concentration of calcium is 0.12 to 0.18 mM per 1 mM citrate greater than the prescribed calcium concentration. 
     
     
       3. The method of  claim 1 , wherein the introduction of the total calcium provides a constant calcium mass transport irrespective of a level of the citrate. 
     
     
       4. The method of  claim 1 , wherein the determination of the prescribed calcium concentration determines the prescribed calcium concentration to be selected from the group consisting of 1.00 mM, 1.25 mM, 1.50 mM, and 1.75 mM. 
     
     
       5. The method of  claim 4 , wherein the prescribed calcium concentration selected from the group consisting of 1.00 mM, 1.25 mM, 1.50 mM, and 1.75 mM results in a blood outlet total calcium value selected from the group consisting of 1.94 mM, 2.17 mM, 2.40 mM, and 2.62 mM, respectively. 
     
     
       6. The method of  claim 1 , wherein the concentration of calcium is 1.1 to 1.2 mM per 1 mM citrate. 
     
     
       7. The method of  claim 1 , wherein the concentration of calcium is 1.12 to 1.18 mM per 1 mM citrate. 
     
     
       8. The method of  claim 1 , wherein the determination of the prescribed calcium concentration is based on at least one of calcium concentration and calcium mass transport for the patient. 
     
     
       9. The method of  claim 1  comprising determining a prescribed concentration of total magnesium for the dialysis fluid, wherein the introduction of the total magnesium results in a concentration of magnesium that is 0.04 to 0.10 mM per 1 mM citrate greater than the prescribed concentration of total magnesium. 
     
     
       10. The method of  claim 9 , wherein the determination of the prescribed magnesium concentration determines the prescribed magnesium concentration to be selected from the group consisting of 0.50 mM, 0.6 mM, and 0.75 mM. 
     
     
       11. The method of  claim 10 , wherein the prescribed magnesium concentration selected from the group consisting of 0.50 mM, 0.6 mM, and 0.75 mM results in a blood outlet total magnesium value of 0.87 mM, 0.95 mM, and 1.07 mM, respectively. 
     
     
       12. The method of  claim 1 , wherein the introduction of the total magnesium provides a constant magnesium mass transport irrespective of a level of the citrate.