Non-woven fabric containing bone prosthetic material

Abstract

An object of the present invention is to provide a bone regeneration material suitable for bone (in particular, alveolar bone) regeneration. The present invention provides a non-woven fabric containing a bone prosthetic material wherein the bone prosthetic material is included between biocompatible fibers that constitute the non-woven fabric. The non-woven fabric may be suitably used as a bone regeneration material (in particular, a dental bone regeneration material).

The invention claimed is: 
     
       1. A non-woven fabric containing a bone prosthetic material wherein the bone prosthetic material is not incorporated in a single fiber, but present between biocompatible fibers that constitute the non-woven fabric, wherein the bone prosthetic material has a particle diameter of about 50 to 5000 μm, the fibers of the non-woven fabric have a porosity of 80 to 99.99%, and the biocompatible fibers have an average fiber diameter of about 0.05 to 20 μm. 
     
     
       2. The non-woven fabric according to  claim 1 , wherein the biocompatible fibers contain a biocompatible polymer. 
     
     
       3. The non-woven fabric according to  claim 2 , wherein the biocompatible polymer is at least one member selected from the group consisting of polylactic acid, polyglycolic acid, polylactic acid-polyglycolic acid copolymer, polycaprolactone, chitin, collagen, polylysine, polyarginine, hyaluronic acid, sericin, cellulose, dextran, and pullulan. 
     
     
       4. The non-woven fabric according to  claim 1 , wherein the bone prosthetic material is at least one member selected from the group consisting of β-tricalcium phosphate, α-tricalcium phosphate, hydroxyapatite, dibasic calcium phosphate dehydrate, octacalcium phosphate, tetracalcium phosphate, alumina, zirconia, calcium aluminate (CaO—Al 2 O 3 ), aluminosilicate (Na 2 O—Al 2 O 3 —SiO 2 ), bioactive glass, quartz, and calcium carbonate. 
     
     
       5. The non-woven fabric according to  claim 1 , wherein the non-woven fabric has a porosity of 78.5 to 97%. 
     
     
       6. The non-woven fabric according to  claim 1 , wherein the bulk density (g/cm 3 ) of the non-woven fabric is 0.1 to 0.6. 
     
     
       7. A bone regeneration material comprising the non-woven fabric according to  claim 1 . 
     
     
       8. An osteoblast culture scaffold material comprising the non-woven fabric according to  claim 1 .