P
US9750802B2ActiveUtilityPatentIndex 94

Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases

Assignee: KOVARIK KATHERINE ROSEPriority: Nov 18, 2009Filed: Sep 20, 2016Granted: Sep 5, 2017
Est. expiryNov 18, 2029(~3.4 yrs left)· nominal 20-yr term from priority
Inventors:KOVARIK KATHERINE ROSEKOVARIK JOSEPH E
A61K 2039/577A61K 35/74C07K 16/00A61K 35/745A61K 35/742A61K 9/0034A61K 35/747A61K 39/0008A61K 2039/55A61K 9/0043A61K 39/35A61K 2039/541A61K 2039/55583A61K 35/741A61K 2039/505A61K 2039/58A61K 9/007A61K 45/06A61K 2039/70A61K 39/395A61K 2039/544A61K 39/39A61K 2300/00
94
PatentIndex Score
31
Cited by
112
References
26
Claims

Abstract

A method and system for targeting the microbiome to promote health involves exposing an expectant mother to a mixture of farm derived manure-containing soil to reduce the chances her baby will suffer allergies and autoimmune diseases. City dwelling expectant mothers are exposed to immunologic agents and allergens in a fashion (e.g., via exposure to farm animal manure-containing soils) that charges their immune system and that of their fetus(es) so that their babies, once born, are provided with immunity against a variety of autoimmune diseases, including allergies commonly and increasingly experienced in modern urban environments.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method of reducing a likelihood of an allergic disease developing, comprising: dispersing, in the air of an urban dwelling where an expectant mother human female resides, a prophylactic immune stimulating composition comprising: at least 5 grams of bovine manure components from a bovine that has not been administered an antibiotic effective against one of  Lactobacillus johnsonii,  and  Bifidobacterium longum  bv.  Infantis,  and an extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis , wherein said step of dispersing includes exposing the expectant mother to said immune stimulating composition so that the expectant mother can inhale the immune stimulating composition laden air within the urban dwelling at least three times a week for at least a 5 minute time period, for at least the expectant mother's last trimester, and applying to the expectant mother's birth canal prior to the birth of her baby with a composition including a bacterial formulation that comprises at least one of:  Prevotella; Lactobacillus johnsonii; Bacteroides fragilis, Lactobacillus ruminus, Bifidobacterium longum  bv.  Infantis,  and an extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis.    
     
     
       2. The method of  claim 1 , wherein the immune stimulating composition is enhanced by the addition of at least one of the following:  L. infantitis, L. johnsonii,  and helminthes. 
     
     
       3. The method of  claim 1 , wherein the composition comprises an extract derived from at least two of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis.    
     
     
       4. The method according to  claim 1 , further comprising providing an air flow device adapted to convey air about said bovine manure components and the urban dwelling. 
     
     
       5. The method according to  claim 1 , wherein said bovine manure components include at least one bacteroidetes selected from a phylum of bacteria of the group  Bacteroides, Flavobacteria,  and  Sphingobacteria,  and at least one gram-positive firmicute. 
     
     
       6. The method according to  claim 1 , wherein said immune stimulating composition further comprises at least 1000 bacteria selected from the group of  Bifidobacterium longum biovar infantis,  and  Lactobacillus johnsonii.    
     
     
       7. The method according to  claim 1 , wherein said immune stimulating composition further comprises at least 1 gram of a helminthes extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, Trichinella spiralis  and  Trichuris suis ova.    
     
     
       8. The method according to  claim 1 , wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan. 
     
     
       9. The method according to  claim 1 , wherein the immune stimulating composition further includes cyclodextrin. 
     
     
       10. The method according to  claim 1 , wherein the immune stimulating composition includes  Lactococcus lactis.    
     
     
       11. The method according to  claim 1 , wherein the immune stimulating composition includes  Lactococcus Latis  and at least one arabinogalactan. 
     
     
       12. A method of reducing a likelihood of an allergic disease developing, comprising: dispersing, in the air of an urban dwelling where an expectant mother human female resides, a prophylactic immune stimulating composition comprising: at least 5 grams of bovine manure components from a bovine that has not been administered an antibiotic effective against one of  Lactobacillus johnsonii,  and  Bifidobacterium longum bv. Infantis,  and an extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis , wherein said step of dispersing includes exposing the expectant mother to said immune stimulating composition so that the expectant mother can inhale the immune stimulating composition laden air within the urban dwelling at least three times a week for at least a 5 minute time period, for at least the expectant mother's last trimester, and applying to the expectant mother's birth canal prior to the birth of her baby with a composition including a bacterial formulation that comprises at least one of:  Prevotella; Lactobacillus johnsonii; Bacteroides fragilis, Lactobacillus ruminus, Bifidobacterium longum bv. Infantis.    
     
     
       13. The method according to  claim 12 , wherein said bovine manure components include at least one bacteroidetes selected from a phylum of bacteria of the group  Bacteroides, Flavobacteria,  and  Sphingobacteria , and at least one gram-positive firmicute. 
     
     
       14. The method according to  claim 12 , wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan. 
     
     
       15. The method according to  claim 12 , wherein the immune stimulating composition further includes cyclodextrin. 
     
     
       16. The method according to  claim 12 , wherein the immune stimulating composition includes  Lactococcus lactis.    
     
     
       17. A method of reducing a likelihood of an allergic disease developing, comprising: dispersing, in the air of an urban dwelling where an expectant mother human female resides, a prophylactic immune stimulating composition comprising: at least 5 grams of bovine manure components from a bovine that has not been administered an antibiotic effective against one of  Lactobacillus johnsonii,  and  Bifidobacterium longum bv. Infantis,  and an extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis , wherein said step of dispersing includes exposing the expectant mother to said immune stimulating composition so that the expectant mother can inhale the immune stimulating composition laden air within the urban dwelling at least three times a week for at least a 5 minute time period, for at least the expectant mother's last trimester, and applying to the expectant mother's birth canal prior to the birth of her baby with a composition including an extract derived from a helminth selected from the group consisting of:  Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus,  and  Trichinella spiralis.    
     
     
       18. The method according to  claim 17 , wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan. 
     
     
       19. The method according to  claim 17 , wherein the immune stimulating composition further includes cyclodextrin. 
     
     
       20. The method according to  claim 17 , wherein the immune stimulating composition includes  Lactococcus lactis.    
     
     
       21. The method according to  claim 1 , wherein the immune stimulating composition includes  Clostridium clostridioforme.    
     
     
       22. The method according to  claim 1 , wherein the allergic disease comprises one of asthma and food allergies. 
     
     
       23. The method according to  claim 12 , wherein the immune stimulating composition includes  Clostridium clostridioforme.    
     
     
       24. The method according to  claim 12 , wherein the allergic disease comprises one of asthma and food allergies. 
     
     
       25. The method according to  claim 17 , wherein the immune stimulating composition includes  Clostridium clostridioforme.    
     
     
       26. The method according to  claim 17 , wherein the allergic disease comprises one of asthma and food allergies.

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