Antithrombotic material

Abstract

An antithrombogenic material includes a coating material containing: a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the polymer is covalently bound to the base material; and an abundance ratio of nitrogen atoms to an abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on a surface of the base material is 6.0 to 12.0 atomic percent.

The invention claimed is: 
     
       1. An antithrombogenic material comprising:
 a coating material containing:
 a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine and diallyldimethylammonium chloride; and 
 an anionic compound containing a sulfur atom and having anticoagulant activity; and 
 
 a base material whose surface is coated with said coating material; 
 wherein 
 said polymer is covalently bound to said base material; and 
 an abundance ratio of nitrogen atoms to an abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on a surface coated with the coating material is 6.0 to 12.0 atomic percent, 
 an abundance ratio of sulfur atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface coated with the coating material is 3.0 to 6.0 atomic percent, and 
 a surface amount estimated based on anti-factor Xa activity after immersion in physiological saline for 30 minutes is not less than 30 mIU/cm 2 . 
 
     
     
       2. The antithrombogenic material according to  claim 1 , wherein said polymer has a quaternary ammonium group. 
     
     
       3. The antithrombogenic material according to  claim 2 , wherein each carbon chain bound to the nitrogen atom in said quaternary ammonium group is constituted by an alkyl group, and the carbon number per alkyl group is 1 to 12. 
     
     
       4. The antithrombogenic material according to  claim 1 , wherein said coating material further comprises:
 an anionic polymer containing, as a constituent monomer, a compound selected from the group consisting of acrylic acid, methacrylic acid, α-glutamic acid, γ-glutamic acid and aspartic acid; or 
 an anionic compound selected from the group consisting of oxalic acid, malonic acid, succinic acid, fumaric acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, malic acid, tartaric acid and citric acid. 
 
     
     
       5. The antithrombogenic material according to  claim 1 , wherein said anionic compound containing a sulfur atom and having anticoagulant activity is heparin or a heparin derivative. 
     
     
       6. The antithrombogenic material according to  claim 1 , wherein weight average molecular weight of said polymer is 600 to 2,000,000. 
     
     
       7. The antithrombogenic material according to  claim 4 , wherein weight average molecular weight of said anionic polymer is 600 to 2,000,000. 
     
     
       8. The antithrombogenic material according to  claim 1 , wherein the abundance ratio of the n2 component as a split peak of nitrogen atoms to a total component of the N1s peak as measured by X-ray photoelectron spectroscopy (XPS) on the surface of the base material is 20 to 70 atomic percent. 
     
     
       9. The antithrombogenic material according to  claim 1 , wherein an abundance ratio of the c3 component as a split peak of carbon atoms to a total component of the C1 s peak as measured by X-ray photoelectron spectroscopy (XPS) on the surface coated with the coating material is not less than 2.0 atomic percent. 
     
     
       10. The antithrombogenic material according to  claim 1 , wherein said coating material has a mean thickness of 1 to 600 nm. 
     
     
       11. The antithrombogenic material according to  claim 1 , wherein nitrogen atoms and sulfur atoms in said coating material are located at a distance of 20 to 100 nm away from an interface between said coating material and said base material.