5-substituted isoindoline compounds

Abstract

This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

What is claimed is: 
     
       1. A method of treating or managing a disease or disorder which comprises administering to a patient in need of such treatment or management a therapeutically effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:
 X is CH 2  or C═O; 
 Z is: (CH 2 ) m , wherein m is 0 or 1; or NH; 
 R 1  is halogen or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen; and 
 R 2  is hydrogen; halogen; or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen; and 
 wherein the disease or disorder is cancer or a disorder associated with angiogenesis. 
 
       
     
     
       2. The method of  claim 1 , wherein the disease or disorder is cancer. 
     
     
       3. The method of  claim 2 , wherein the cancer is a cancer of the skin, lung, ovary, prostate, colon, rectum, brain, head and neck, throat, pancreas, blood, bone, liver or bladder.