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US9820947B2ActiveUtilityPatentIndex 46

Method of manufacturing enteric seamless soft capsule

Assignee: FUJI CAPSULE CO LTDPriority: Oct 6, 2014Filed: Oct 6, 2015Granted: Nov 21, 2017
Est. expiryOct 6, 2034(~8.3 yrs left)· nominal 20-yr term from priority
Inventors:MASUDA KOJINISHIMURA NAOKIHAYANO AKIHIKOSHIMOKAWA YOSHIYUKIKATO KENJI
A61K 47/10A61K 9/4866A61K 47/36A61K 31/202A61K 47/42A61K 9/4833A61K 9/4816A61K 9/4825
46
PatentIndex Score
0
Cited by
14
References
20
Claims

Abstract

An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50° C. of 60 to 127 mPa·s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method of manufacturing an enteric seamless soft capsule, comprising the following steps (a) and (b):
 (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50° C. of 60 to 127 mPa·s; and 
 (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. 
 
     
     
       2. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein a jelly strength of the gelatin is 180 to 330 Bloom. 
     
     
       3. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s. 
     
     
       4. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 
     
     
       5. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       6. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein the low methoxy pectin has a degree of amidation of 5 to 25%. 
     
     
       7. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed with standing. 
     
     
       8. The method of manufacturing an enteric seamless soft capsule according to  claim 1 , wherein the encapsulating is performed such that an enteric capsule shell rate is 9 to 30 mass %. 
     
     
       9. The method of manufacturing an enteric seamless soft capsule according to  claim 2 , wherein an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s. 
     
     
       10. The method of manufacturing an enteric seamless soft capsule according to  claim 2 , wherein the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 
     
     
       11. The method of manufacturing an enteric seamless soft capsule according to  claim 3 , wherein the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 
     
     
       12. The method of manufacturing an enteric seamless soft capsule according to  claim 9 , wherein the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 
     
     
       13. The method of manufacturing an enteric seamless soft capsule according to  claim 2 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       14. The method of manufacturing an enteric seamless soft capsule according to  claim 3 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       15. The method of manufacturing an enteric seamless soft capsule according to  claim 4 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       16. The method of manufacturing an enteric seamless soft capsule according to  claim 9 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       17. The method of manufacturing an enteric seamless soft capsule according to  claim 10 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       18. The method of manufacturing an enteric seamless soft capsule according to  claim 11 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       19. The method of manufacturing an enteric seamless soft capsule according to  claim 12 , wherein the enteric capsule shell liquid has a viscosity at 50° C. of 70 to 110 mPa·s. 
     
     
       20. The method of manufacturing an enteric seamless soft capsule according to  claim 2 , wherein the low methoxy pectin has a degree of amidation of 5 to 25%.

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