US9856240B2ActiveUtilityPatentIndex 73
Compounds that modulate intracellular calcium
Est. expiryOct 19, 2031(~5.3 yrs left)· nominal 20-yr term from priority
A61P 37/00C07D 413/14C07D 277/54C07D 417/14A61P 29/00C07D 405/14
73
PatentIndex Score
5
Cited by
108
References
20
Claims
Abstract
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. A compound having the structure of Formula (I):
wherein:
X is CH or N;
R 1 is Cl or CH 3 ;
each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl;
R 3 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 3 -C 8 cycloalkyl;
m is an integer selected from 0-3;
n is an integer selected from 0-2;
p is an integer selected from 1-2;
or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.
2. The compound of claim 1 wherein X is CH.
3. The compound of claim 2 wherein A is
4. The compound of claim 3 wherein n is 1.
5. The compound of claim 4 wherein R 2 is C 1 -C 6 alkyl.
6. The compound of claim 4 wherein R 2 is halogen.
7. The compound of claim 3 wherein n is 2.
8. The compound of claim 7 wherein each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl.
9. The compound of claim 8 wherein each R 2 is independently selected from Cl, CH 3 , and CF 3 .
10. The compound of claim 3 wherein R 3 is C 1 -C 6 alkyl.
11. The compound of claim 1 wherein X is N.
12. The compound of claim 11 wherein A is
13. The compound of claim 12 wherein n is 1.
14. The compound of claim 13 wherein R 2 is C 1 -C 6 alkyl.
15. The compound of claim 13 wherein R 2 is halogen.
16. The compound of claim 12 wherein n is 2.
17. The compound of claim 16 wherein each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl.
18. The compound of claim 17 wherein each R 2 is independently selected from Cl, CH 3 , and CF 3 .
19. The compound of claim 12 wherein R 3 is C 1 -C 6 alkyl.
20. A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of claim 1 or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.Cited by (0)
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