Compositions and methods for stimulation MAGP-1 to improve the appearance of skin

Abstract

The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.

What is claimed is: 
     
       1. A method for improving the condition or aesthetic appearance of human skin comprising topically applying to skin in need thereof an effective amount of a composition comprising:
 (i) a MAGP-1 active agent is
 an ethanolic extract of  Antidesma bunius , and 
 
 (ii) a cosmetically acceptable vehicle, 
 
       wherein said improvement is selected from the group consisting of:
 (a) treatment, reduction, and/or prevention of fine lines or wrinkles, 
 (b) reduction of skin pore size, 
 (c) improvement in skin thickness, plumpness, and/or firmness; 
 (d) improvement in skin suppleness and/or softness; 
 (e) improvement in skin tone, radiance, and/or clarity; 
 (f) improvement in procollagen and/or collagen production; 
 (g) improvement in maintenance and remodeling of elastin; 
 (h) improvement in skin texture and/or promotion of retexturization; 
 (i) improvement in skin barrier repair and/or function; 
 (j) improvement in appearance of skin contours; 
 (k) restoration of skin luster and/or brightness; 
 (l) replenishment of essential nutrients and/or constituents in the skin; 
 (m) improvement of skin appearance decreased by menopause; 
 (n) improvement in skin moisturization; 
 (o) increase in skin elasticity and/or resiliency; 
 (p) treatment, reduction, and/or prevention of skin sagging; and 
 (q) reduction of pigment spots; or any combination thereof. 
 
     
     
       2. The method according to  claim 1 , wherein said improvement is the treatment, reduction, and/or prevention of fine lines or wrinkles. 
     
     
       3. The method according to  claim 1 , wherein said improvement is an increase in skin elasticity and/or resiliency. 
     
     
       4. The method according to  claim 1 , wherein said improvement is the treatment, reduction, and/or prevention of skin sagging. 
     
     
       5. The method according to  claim 1 , wherein the composition is topically applied at least once daily for at least one week.