Penicillin binding protein from Streptococcus pneumoniae

Abstract

The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae . Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.

We claim:  
     
       1. An isolated Penicillin Binding Protein Nv2 S  from  Streptococcus pneumoniae  consisting of amino acid residues 85 through 821 of SEQ ID NO:2. 
     
     
       2. An isolated Penicillin Binding Protein Nv2 S  from  Streptococcus pneumoniae  consisting essentially of amino acid residues 85 through 821 of SEQ ID NO:2.