X-ray micro-tube and method of use in radiation oncology

Abstract

An apparatus and method for the treatment of a patient having a tumor is disclosed. An X-ray generating source is positionable at a location in close proximity to the tumor. The X-ray generating source is operable at a voltage level in the range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by the tumor and minimizing the side effects of radiation therapy on the patient's normal tissue.

What is claimed and desired to be secured to Letters Patent of the United States is: 
     
       1. An apparatus for the treatment of a patient having a tumor, comprising: an X-ray generating source insertable into the body of said patient to a location in close proximity to said tumor, said X-ray generating source comprising a substantially cylindrical glass X-ray tube having a length on the order of one-quarter to two inches and a diameter less than one inch and being operable at a voltage level in the range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue.   
     
     
       2. The apparatus of claim 1, wherein said X-ray generating source includes a metal-jacketed micro-tube assembly, comprising: a) an evacuated glass tube;   b) a cathode supported within said evacuated glass tube;   c) an anode supported within said evacuated glass tube;   d) support means for supporting said cathode and said anode;   e) a metal jacket enclosing said evacuated glass tube therein, said metal jacket including a window for directing the generated radiation in the desired manner; and,   f) electrical connection means for connecting said cathode and said anode to a source of electrical power.   
     
     
       3. The apparatus of claim 1, wherein said glass X-ray tube contains a stable vacuum of at most 10 -6  Torr. 
     
     
       4. The apparatus of claim 3, wherein said glass X-ray tube is a cold emission cathode tube. 
     
     
       5. The apparatus of claim 3, wherein said glass X-ray tube includes a heated filament cathode. 
     
     
       6. The apparatus of claim 3, further including a power source for operating said glass X-ray tube at a frequency range of d.c. to 1,000,000 cycles per second. 
     
     
       7. The apparatus of claim 3, further including a power source for operating said glass X-ray tube at a frequency in the range between 70,000 and 1,000,000 cycles per second. 
     
     
       8. The apparatus of claim 1, wherein said glass X-ray tube has a length of approximately one inch and a diameter of approximately one-quarter inch or less. 
     
     
       9. The apparatus of claim 1, wherein said X-ray generating source includes a liquid-cooled micro-tube assembly, comprising: a) an evacuated glass tube;   b) a filament cathode supported within said evacuated glass tube;   c) an anode supported within said evacuated glass tube;   d) support means for supporting said cathode and said anode;   e) a housing for supporting and enclosing said evacuated glass tube therein, a liquid coolant chamber being formed between said housing and said glass tube;   f) electrical connection means for connecting said cathode and said anode to a source of electrical power; and,   g) coolant conduits for supplying coolant to said coolant chamber.   
     
     
       10. An X-ray micro-tube for the treatment of a patient having a tumor, comprising: a substantially cylindrical evacuated glass X-ray tube having a length on the order of one-quarter to two inches and a diameter less than one inch and containing a stable vacuum of, at most, 10 -6  Torr, said glass X-ray tube being locatable at a location in close proximity to said tumor, said X-ray tube being operable at a voltage level in the range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue.   
     
     
       11. The X-ray micro-tube of claim 10, wherein said glass X-ray tube operates at a frequency of between d.c. and 1,000,000 cycles per second. 
     
     
       12. The X-ray micro-tube of claim 11, wherein said glass X-ray tube operates at a frequency in the range between 70,000 and 1,000,000 cycles per second. 
     
     
       13. The X-ray micro-tube of claim 12, wherein said glass X-ray tube includes a coolant jacket positioned about its periphery. 
     
     
       14. The X-ray micro-tube of claim 12, further including protective shielding circumscribing said glass X-ray tube for patient protection in the event of glass breakage. 
     
     
       15. A method for the in-situ treatment of a patient having a tumor, comprising: (a) providing an X-ray generating source comprising a substantially cylindrical glass X-ray tube having a length on the order of one-quarter to two inches and a diameter less than one inch and being operable at a voltage level in the range of approximately 10-60 KeV;   (b) positioning said X-ray generating source at a location in close proximity to said tumor; and,   (c) applying power to said X-ray generating source in said range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue.   
     
     
       16. The method of claim 15 wherein said step of positioning said X-ray generating source includes inserting said source into the body of said patient to a location in close proximity to said tumor. .Iadd. 
     
     
       17.  An apparatus for the treatment of a patient having a tumor, comprising: an X-ray generating source insertable into the body of said patient to a location in close proximity to said tumor, said X-ray generating source comprising a substantially cylindrical glass X-ray tube having a diameter less than one inch and being operable at a voltage level in the range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue. .Iaddend. .Iadd.18. An X-ray micro-tube for the treatment of a patient having a tumor, comprising:   a substantially cylindrical evacuated glass X-ray tube having a diameter less than one inch and containing a stable vacuum of, at most, 10 -6  Torr, said glass X-ray tube being locatable at a location in close proximity to said tumor, said X-ray tube being operable at a voltage level in the range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue. .Iaddend. .Iadd.19. A method for the in-situ treatment of a patient having a tumor, comprising:   (a) providing an X-ray generating source comprising a substantially cylindrical glass X-ray tube having a diameter less than one inch and being operable at a voltage level in the range of approximately 10-60 KeV;   (b) positioning said X-ray generating source at a location in close proximity to said tumor; and,   (c) applying power to said X-ray generating source in said range of approximately 10-60 KeV, thereby enhancing absorption of the generated X-rays by said tumor and minimizing the side effects of radiation therapy on the patient's normal tissue. .Iaddend.