Separating agent

Abstract

A mixture of chemical substances such as optical isomers, geometrical isomers and polymers having different molecular weight ranges is separated to each ingredient by use of a cellulose derivative having an aromatic ring in the chromatographic method.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 
     
       1. A separating agent which comprises a cellulose derivative selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl, said cellulose derivative being supported on a porous carrier having a particle size of from 1 micron to 10 millimeters and a pore size of from 10 Angstrom units to 100 microns. 
     
     
       2. A separating agent as claimed in claim 1 in which said cellulose derivative is cellulose tribenzoate. 
     
     
       3. A separating agent as claimed in claim 1, wherein the amount of said cellulose derivative supported on said carrier is from 1-100 wt. % based on the weight of the carrier. 
     
     
       4. A separating agent as claimed in claim 1, wherein the ratio of pore size to particle size of said carrier is not larger than 0.1:1. 
     
     
       5. A separating agent as claimed in claim 1, wherein said carrier is an inorganic substance selected from the group consisting of silica, alumina, magnesia, titanium oxide, glass, silicate and kaolin. 
     
     
       6. A separating agent as claimed in claim 1, wherein said carrier is an organic substance selected from the group consisting of polystyrene, polyacrylamide and polyacrylate. 
     
     
       7. A separating agent as claimed in claim 1 in which said cellulose derivative is coated on said carrier and has been prepared by mixing said carrier with a solution of said cellulose derivative in a solvent therefor, and then removing said solvent. 
     
     
       8. A separating agent as claimed in claim 1, in which said carrier is an inorganic substance. 
     
     
       9. A separating agent as claimed in claim 8, in which said inorganic substance is silica gel. 
     
     
       10. A chromatographic isomer separating agent comprising a derivative of cellulose selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl having a number average degree of polymerization in the range of 5-5000 supported on a solid carrier having a particle size of from 1 micron to 10 millimeters. 
     
     
       11. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tribenzoate. 
     
     
       12. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(3-chlorobenzoate). 
     
     
       13. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(3,5-dichlorobenzoate). 
     
     
       14. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(4-chlorobenzoate). 
     
     
       15. A chromatographic isomer separating agent as claimed in claim 10, wherein said cellulose derivative is immobilized on solid carrier particles, wherein said carrier particles are from 1 μm-10 mm in diameter and the amount of said cellulose derivative supported is from 1-100 wt. % based on the weight of the carrier particles. 
     
     
       16. A chromatographic isomer separating agent as claimed in claim 15 wherein said carrier particles are porous and have pore diameters of from 10 Å-100 μm. 
     
     
       17. A chromatographic isomer separating agent as claimed in claim 16, wherein said carrier particles have an approximate pore size to particle size ratio of no greater than 0.1:1. 
     
     
       18. A chromatographic isomer separating agent as claimed in claim 15, wherein said carrier is an inorganic substance selected from among silica, alumina, magnesia, titanium oxide, glass, silicate and kaolin. 
     
     
       19. A chromatographic isomer separating agent as claimed in claim 15, wherein said carrier is silica gel. 
     
     
       20. A chromatographic isomer separating agent as claimed in claim 15, wherein said carrier is an organic substance selected from the group consisting of polystyrene, polyacrylamide and polyacrylate. .Iadd. 
     
     
       21.  In a chromatographic column used in the separation of a chemical substance from a mixture containing the same, the improvement comprising said column containing a carrier having supported thereon a separating agent selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl..Iaddend. .Iadd.22. The column of claim 21, wherein said carrier is in the form of particles..Iaddend. .Iadd.23. The column of claim 22, wherein said carrier has a particle size of about from 1 μm to about 10 mm..Iaddend. 
     
     
        .Iadd.  .  The column of claim 21, wherein said separating agent is cellulose tribenzoate..Iaddend. .Iadd.25. The column of claim 21, wherein said separating agent is cellulose tribenzoate ring substituted with a group selected from among an alkyl group, an alkenyl group, an alkynyl group, a nitro group, a halogen group, an amino group, an alkyl-substituted amino group, a cyano group, a hydroxyl group, an alkoxy group, an acyl group, a thiol group, a sulfonyl group, a carboxyl group and an alkoxy carbonyl group..Iaddend. .Iadd.26. In a chromatographic column used in the separation of a chemical substance from a mixture containing the same, the improvement comprising said column containing a separating agent in the form of beads and selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxy, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl, said separating agent having a degree of polymerization of from 5 to 5000..Iaddend. .Iadd.27. The column of claim 26, wherein said separating agent is supported on a carrier..Iaddend. .Iadd.28. The column of claim 26, wherein said separating agent has a particle size of about from 1 μm to about 10 mm..Iaddend. .Iadd.29. The column of claim 26, wherein said separating agent is cellulose tribenzoate..Iaddend. .Iadd.30. The column of claim 26, wherein said separating agent is cellulose tribenzoate ring substituted with a group selected from among an alkyl group, an alkenyl group, an alkynyl group, a nitro group, a halogen group, an amino group, an alkyl-substituted amino group, a cyano group, a hydroxyl group, an alkoxy group, an acyl group, a thiol group, a sulfonyl group, a carboxyl group and an alkoxy carbonyl group..Iaddend.