Transdermal therapeutic system

Abstract

The invention relates to a transdermal therapeutic system for administering or applying active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control means controlling the delivery of the active substance through the system and a .[.contact.]. .Iadd.pressure sensitive .Iaddend.adhesive means for fixing the therapeutic system to the skin, in which the active substance depot is a multichamber system, in which discreet chambers contain one or more active substances.

I claim: 
     
       1. A transdermal therapeutic system for the controlled administration of active substance to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control device controlling the delivery of the active substance through the system and a .[.contact.]. .Iadd.pressure sensitive .Iaddend.adhesive fixing means for fixing the therapeutic system to the skin, characterized in that the active substance depot is a multichamber system, in which the chambers are interconnected by channels and are provided with active substance delivery control means. 
     
     
       2. Transdermal therapeutic system according to claim 1, characterized in that the chambers are arranged in one or more identical active substance distribution matrices. 
     
     
       3. Transdermal therapeutic system according to claim 2, characterized in that it has an uninterrupted skin-side .[.contact.]. .Iadd.pressure sensitive .Iaddend.adhesive layer as a fixing means. 
     
     
       4. Transdermal therapeutic system according to claim 3, characterized in that it also has one or more .[.contact.]. .Iadd.pressure sensitive .Iaddend.adhesive layers between the backing layer and fixing means. 
     
     
       5. Transdermal therapeutic system according to claim 4, characterized in that the active substance is in liquid form. 
     
     
       6. Transdermal therapeutic system according to claim 5, characterized in that the multichamber system has desired breaking lines between the individual active substance chambers. 
     
     
       7. Transdermal therapeutic system according to claim 6, characterized in that the channels between the chambers have an internal diameter such that they only permit a through-flow of the active substance fluid upon application of pressure thereto. 
     
     
       8. Transdermal therapeutic system according to claim 7, characterized in that the multichamber system is a system of channels. 
     
     
       9. Transdermal therapeutic system according to claim 8, characterized in that the chambers are arranged at different height levels. 
     
     
       10. Transdermal therapeutic system according to claim 1, wherein the chambers are each provided with different active substance delivery control means. 
     
     
       11. Transdermal therapeutic system according to claim 2, characterized in that it has an interrupted skinside .[.contact.]. .Iadd.pressure sensitive .Iaddend.adhesive layer as a fixing means to the skin. 
     
     
       12. Transdermal therapeutic system according to claim 4, characterized in that the active substance is in solution. 
     
     
       13. Transdermal therapeutic system according to claim 5, characterized in that the multichamber system has desired breaking lines between the individual active substance chambers and in the backing layer. 
     
     
       14. Transdermal therapeutic system according to claim 13, further characterized in that the multichamber system has desired breaking lines also in other layers. 
     
     
       15. Transdermal therapeutic system according to claim 9, characterized in that the chambers are arranged at different height levels and in different distribution matrices.