USRE34698EExpiredUtilityPatentIndex 47

Method of producing salinomycin antibiotics

Assignee: KAKEN CHEMICAL COPriority: May 31, 1977Filed: Jan 29, 1993Granted: Aug 16, 1994

Est. expiryMay 31, 1997(expired)· nominal 20-yr term from priority

Inventors:MIYAZAKI YUKIO SHIBATA AKIRA YAHAGI TATEO HARA MASAYUKI HARA KAORU YONEDA SINGO KASAHARA HIROKO NAKAMURA YUKO

C07D 493/20C07H 19/01C12P 17/181

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Abstract

Polyether type antibiotics are produced by culturing a polyether type antibiotic-producing microorganism is a medium containing a fatty acid or its precursor and ammonia or an ammonium salt or urea.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
       1. A method of producing salinomycins, which comprises culturing a salinomycins-producing Streptomyces microorganism in a medium containing .Iadd.12-25% .Iaddend.fatty acid or its precursor and ammonia or an ammonium salt and recovering the salinomycins from the culture. 
     
     
       2. The method of claim 1 wherein salinomycin is recovered together with the mycelial mass from the culture. 
     
     
       3. The method of claim 1 or 2 wherein SY-1, SY-2, SY-3, SY-4, SY-5, and/or SY-6 is recovered from the culture. 
     
     
       4. The method of claim 1, wherein salinomycin, 4-methylsalinomycin, SY-1, SY-2, SY-3, SY-4, SY-5, SY-6, SY-7 and/or SY-8 is recovered from the culture.

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