Carrier for coating with immunologically-active material

Abstract

The present invention provides a carrier for coating with immunologically-active material, wherein it consists of an injection molded synthetic resin with a content of adjuvant and additional materials of less than 1% by weight. The present invention also provides a carrier coated with immunologically-active material, wherein the carrier consists of synthetic resin with a content of adjuvant and additional materials of less than 1% by weight.

What is claimed is: 
     
       1. Process for producing a carrier coated with an immunologically active material having a variation coefficient of less than 5%, comprising: injection molding a synthetic resin having a content of adjuvant or additional materials selected from the group consisting of stabilizers, lubricants, plasticisers, separating agents, pigments and filling materials of less than 1% by weight .[.at a temperature of from 190° to 280° C., said temperature being regulated so as not to very by more of less than 2° C.,   cooling said injection molded synthetic resin at a temperature of from 20° C., to 40° C., wherein said temperature does not vary by more or less than 1° C..].,   loading said injection molded synthetic synthetic resin by incubating it with a solution of an immunologically active material, and drying the loaded injection molded synthetic resin.   
     
     
       2. Process of claim 1, wherein said synthetic resin is injection molded at a pressure of from 100 to lb 250 bar, wherein said pressure is regulated to vary by not more or less than 2 bar. 
     
     
       3. The process of claim 1, wherein said injection molded synthetic resin and said solution of immunologically active material are incubated at a temperature of from 15° C. to 30° C., said incubating temperature being regulated so as to vary by not more or less than 0.5° C. 
     
     
       4. The process of claim 1, wherein said injection molded synthetic resin and said solution of immunologically active material are incubated for a period of from 12 to 24 hours. 
     
     
       5. The process of claim 1, wherein said solution of immunologically active material has a pH of from 5 to 8. 
     
     
       6. The process of claim 1, comprising drying said loaded injection molded synthetic resin for from 14 to 16 hours. 
     
     
       7. The process of claim 1 wherein the loading step comprises applying a solution of the immunologically active material to the injected molded synthetic resin while maintaining a temperature in the range of 15° C., to 30° C., with a variation of ±0.5° C., for 12 to 24 hours and thereafter exposing the resin to a salt containing stabilizing solution for 10 to 120 minutes. 
     
     
       8. The process of claim 1 wherein the synthetic resin is selected from the group consisting of polystyrene, Luran, polypropylene and polyvinyl chloride. 
     
     
       9. The process of claim 8 wherein the synthetic resin is Luran with a content of adjuvant and additional materials of less than 0.2% by weight. 
     
     
       10. The process of claim 8 wherein the synthetic resin is polystyrene with a content of adjuvant and additional materials of less than 0.05% by weight. 
     
     
       11. Method for determining an analtye in a sample comprising contacting a liquid sample with an immunologically active material prepared in accordance with the process of claim 1, wherein said immunologically active material reacts with said analyte to form a complex thereby, and determining said complex as a determination of said analyte. .[.12. Immunologically active injection molded synthetic resin carrier prepared 
     
     
        by the process of claim 1..]. 13. The carrier .Iadd.material .Iaddend.of claim .[.12.]. .Iadd.17.Iaddend., wherein the synthetic resin .[.used.]. is selected from the group consisting of polystyrene, Luran, polypropylene 
     
     
        and polyvinyl chloride. 14. The carrier of claim 12 wherein the synthetic resin is polystyrene with a content of adjuvant and additional materials 
     
     
        of less than 0.5% by weight. 15. The carrier .Iadd.material .Iaddend.of claim .[.12.]. .Iadd.17 .Iaddend.wherein the synthetic resin is Luran with a content of adjuvant and additional materials of less than 0.02% by 
     
     
        weight. .Iadd.16.  Process of claim 1, wherein said injection molding is carried out at a temperature of from 190° to 280° C., said temperature being regulated so as not to vary more or less than 2° C., said process further comprising cooling said injection molded synthetic resin at a temperature of from 20° C. to 40° C., wherein said temperature does not vary by more or less than 1° C. .Iaddend. .Iadd.17. Injection molded, immunologically active carrier material having a variation coefficient of less than 5% and consisting of: (a) a synthetic resin,   (b) a content of adjuvant or additional material of less than 1%, wherein said adjuvant or additional material is selected from the group consisting of: a stabilizer, a lubricant, a plasticiser, a separating agent, a pigment and a filling material, and   (c) an immunologically active material loaded therein. .Iaddend.