Separation media containing acyl diazepines

Abstract

Method of chromatographically separating a mixture by contacting said mixture under chromatographic separation conditions with a chromatographic separation stationary phase comprising an N-acyl diazepine polymer. In a preferred from, the polymer has been rendered substantially alkali-stable by substitution for the hydrogen at the C3 position on the diazepine ring.

What is claimed is: .[.1. A chromatographic separation medium comprising a chromatographic inert substrate having a coating comprising a polymeric N-acyl diazepine moiety of the general formula: ##STR9## where R is a hydrogen, alkyl, aryl, alkaryl or aralkyl, R 2  is a divalent alkylene radical, and R 3  is an alkyl, aryl, alkaryl or 
     
        aralkyl group..]. .[.2.  A chromatographic separation medium as defined in claim 1 wherein said coating is a copolymer of said diazepine moiety and a copolymeric moiety..]. .[.3. A chromatographic separation medium as defined in claim 2 wherein said copolymeric moiety has the general formula: ##STR10## where R 6  is alkyl, aryl, alkaryl or aralkyl, and R 5  is 
     
     
        alklylene..]. .[.4.  A chromatographic separation medium comprising a chromatographic inert substrate having a coating comprising a polymeric N-acyl diazepine moiety of the general formula: ##STR11## 
     
     
        .]. .[.5.  A chromatographic separation medium as defined in claim 1 wherein said substrate is in the form of a plurality of particles of substantially uniform size in the range of between about 1 to 300 μm in diameter..]. .[.6. A chromatographic separation medium as defined in claim 5 wherein said particles are substantially imporous..]. .[.7. A chromatographic separation medium as defined in claim 5 wherein said particles are substantially porous and have an average pore diameter in the range of between about 50 to 50,000 A..]. .[.8. A chromatographic separation medium as defined in claim 1 wherein said substrate is selected from the group consisting of silica, alumina, magnesia, titania and zirconia..]. .[.9. Method of manufacturing a chromatographic column packing comprising the step of coating onto a chromatographically inert substrate, an N-acyl diazepine polymer..]. .Iadd.10. A polymeric pyridinium ylide comprising a plurality of repeating units having the formula ##STR12##