USRE36575EExpiredUtility

Pyridine and thiazolidinedione derivatives

63
Assignee: TAKEDA CHEMICAL INDUSTRIES LTDPriority: Jul 24, 1986Filed: Oct 10, 1997Granted: Feb 15, 2000
Est. expiryJul 24, 2006(expired)· nominal 20-yr term from priority
A61P 3/08C07D 417/12C07D 213/30
63
PatentIndex Score
16
Cited by
8
References
1
Claims

Abstract

A compound of the formula: ##STR1## (wherein R 1 is hydrogen or a lower alkyl) can be produced advantageously by (1) reacting a compound of the formula: ##STR2## (wherein R 1 has the meaning given above) with a halogenating agent or sulfonyl halide to give a compound of the formula: ##STR3## (wherein R 1 has the meaning given above and X is a halogen or an alkyl- or aryl-sulfonyloxy), (2) reacting the resulting compound with a compound of the formula: ##STR4## to give a compound of the formula: ##STR5## (wherein R 1 has the meaning given above), (3) reacting the resulting compound with a compound of the formula: ##STR6## to give a compound of the formula: ##STR7## (wherein R 1 has the meaning given above), and (4) subjecting the resulting compound to catalytic reduction.

Claims

exact text as granted — not AI-modified
We claim: .[.1. A compound of the formula: ##STR18## 
     
        wherein R 1  is hydrogen or a lower alkyl..].2. A compound of the formula: ##STR19## wherein R 1  is hydrogen or a lower alkyl. .Iadd.3. The compound according to claim 2, wherein R 1  is ethyl. .Iaddend..Iadd.4. A compound of the formula ##STR20## wherein R 1  is hydrogen or a lower alkyl, excluding 4-[2-(6-methyl-2-pyridyl)ethoxy]benzaldehyde and 4-[2-(2-pyridyl)ethoxy]benzaldehyde. .Iaddend..Iadd.5. The compound according to claim 4, wherein R 1  is ethyl. .Iaddend.

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