Anti-inflammatory formulations for inflammatory diseases

Abstract

There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic and anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis).

What is claimed is:  
     
       1. A method for reducing tissue inflammation comprising topically applying a pharmaceutically effective amount of an anti-inflammatory composition comprising a mixture of a first solution, cream, or gel consisting essentially of a chlorine dioxide liberating compound and a second solution, cream, or gel consisting essentially of a protic acid, wherein the chlorine dioxide liberating compound comprises a metal chlorite, and wherein the chlorite ion concentration in the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration in the composition and wherein the gel or cream optionally contains a thickener. 
     
     
       2. The method of claim  1  wherein the pK of the protic acid is from about 2.8 to about 4.2. 
     
     
       3. The method of claim  1  wherein the first solution, cream, or gel is a gel and contains a polysulfonic acid salt as a thickener. 
     
     
       4. A method for treating inflammatory disorders comprising locally administering a pharmaceutically effective amount of a composition comprising a first solution or gel consisting essentially of a chlorine dioxide liberating compound, and a second solution or gel consisting essentially of a protic acid, wherein the chlorine dioxide liberating compound comprises a metal chlorite, and wherein the chlorite ion concentration in the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration in the composition and wherein the gel or cream optionally contains a thickener. 
     
     
       5. The method of claim  4  wherein the pK of the protic acid is from about 2.8 to about 4.2. 
     
     
       6. The method of claim  5  wherein the chlorine dioxide liberating compound is sodium chlorite. 
     
     
       7. The method of claim  4  wherein the inflammatory disorder is selected from the group consisting of arthritis, lupus, bowel inflammation, tendon inflammation and muscle inflammation. 
     
     
       8. The method of claim  1  wherein the tissue inflammation is a viral lesion. 
     
     
       9. The method of claim  8  wherein the viral lesion is a herpes lesion. 
     
     
       10. The method of claim  1  wherein the tissue inflammation is a wound site.