Glibenclamide-metformin combination for the treatment of diabetes mellitus of type II

Abstract

Non-insulin dependent diabetes mellitus in cases of secondary failure is treated with a combination of glibenclamide and metformin.

We claim:  
     
       1. A method of treating non-insulin dependent diabetes mellitus in cases of secondary failure comprising administering to a subject a need of same  to a treatment utilizing a combination of glibenclamide and metformin, expressed as the  glibenclamide- metformin hydrochloride in a weight ratio higher than  1 : 100 , comprising administering to a subject in need of same a combination of glibenclamide and metformin, expressed as the  hydrochloride, in a weight ratio higher than  of 1:100. 
     
     
       2. A method of treating non-insulin dependent diabetes mellitus in cases of secondary failure comprising administering to a subject in need of same  to a treatment utilizing a combination of glibenclamide- metformin hydrochloride in a weight ratio of  1 : 160  to  1 : 200 , comprising administering to a subject in need of same  a combination of glibenclamide and metformin, expressed as the hydrochloride, in a weight ratio of 1:160 to 1:200   1 : 100 . 
     
     
       3. The method according to claim  1  or  2  wherein a daily dosage of up to 15 mg of glibenclamide and 1500 mg of metformin is administered. 
     
     
       4. The method according to claim  1  or  2  wherein a unitary dose administered contains 5 mg of glibenclamide and 500 mg of metformin. 
     
     
       5. The method according to claim  4  wherein the medicament  unitary dose is in the form of a tablet. 
     
     
       6. The method according to claim  5  wherein the table its  tablet is divisible. 
     
     
       7. The method according to claim  1  or  2  in which a metformin salt is a hydrochloride.