USRE37718EExpiredUtility

Ion beam modification of bioactive ceramics to accelerate biointegration of said ceramics

Assignee: SOUTHWEST RES INSTPriority: Aug 4, 1994Filed: Apr 2, 1997Granted: May 28, 2002

Est. expiryAug 4, 2014(expired)· nominal 20-yr term from priority

Inventors:Cheryl R. Blanchard Geoffrey Dearnaley James Lankford, Jr.

C23C 14/48A61F 2310/00203A61F 2/3094A61F 2310/00179A61F 2310/00293A61F 2210/0004A61L 27/32A61F 2/30767A61F 2310/00796A61F 2002/30062

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Claims

Abstract

The present invention provides for faster and stronger tissue-implant bonding by treating a ceramic implant with an ion beam to modify the surface of the ceramic. The surface modification can give the ceramic improved ion-exchange properties depending upon the particular ceramic and the type of ions used. In a preferred embodiment, a bioactive ceramic orthopaedic, dental, or soft tissue implant is bombarded with a beam of cations. When implanted in the body, the surface modification causes an increase in the release of critical ions, such as calcium or phosphorus, from the surface of the ceramic implant, and thereby accelerates implant-tissue bond formation.

Claims

exact text as granted — not AI-modified

We claim:

1. A process for increasing the bioactivity and improving the biointegration of a bioactive ceramic implant comprising treating said ceramic implant with ions in a vacuum at a dose and energy sufficient power density of from about 0 . 1 to about 0 . 5 watts/cm 2 to form a biologically-active calcium hydrocarbonate apatite layer on the surface of said ceramic implant when said ceramic implant is placed in an actual or simulated body fluid, wherein said ions are positive ions selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorous ions and combinations thereof.

2. The process of claim 1 A process for increasing the bioactivity and improving the biointegration of a bioactive ceramic implant comprising treating said ceramic implant with ions in a vacuum at a power density of from about 0 . 1 to about 0 . 5 watts/cm 2 to form a biologically - active calcium hydrocarbonate apatite layer on the surface of said ceramic implant when said ceramic implant is placed in actual or simulated body fluid, wherein said increased bioactivity comprises the formation of calcium hydrocarbonate apatite on the surface of said implant at least about five minutes earlier than the formation of the calcium hydrocarbonate apatite on the surface of a untreated ceramic implant.

3. The process of claim 1 wherein said increased bioactivity comprises the formation of calcium hydrocarbonate apatite on the surface of said implant at least about one hour earlier than the formation the calcium hydrocarbonate apatite of on the surface of a untreated ceramic implant.

4. The process of claim 1 wherein said energy and said dose are at levels which maintain the power density between about 0.1-0.5 watts/cm 2 , and said vacuum is less than about 10 −5 torr.

5. The process of claim 2 wherein said energy and said dose are at levels which maintain the power density between about 0.1-0.5 watts/cm 2 , and said vacuum is less than about 10 −5 torr.

6. The process of claim 3 wherein said energy and said dose are at levels which maintain the power density between about 0.1-0.5 watts/cm 2 , and said vacuum is less than about 10 −5 torr.

7. The process of claim 1 wherein said ions have an energy is of at least about 50 keV, and said vacuum is less than about 10 −5 torr.

8. The process of claim 2 wherein said ions have an energy is of at least about 50 keV, and said vacuum is less than about 10 −5 torr.

9. The process of claim 1 wherein said ceramic implant is an amorphous or glass-ceramic oxide.

10. The process of claim 2 wherein said ceramic implant is comprised of an amorphous or glass-ceramic oxide.

11. The process of claim 3 wherein said ceramic implant is comprised of an amorphous or glass-ceramic oxide.

12. The process of claim 6 wherein said ceramic implant is comprised of an amorphous or glass-ceramic oxide.

13. The process of claim 8 wherein said ceramic implant is comprised of an amorphous or glass-ceramic oxide.

14. The process of claim 1 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

15. The process of claim 2 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

16. The process of claim 3 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

17. The process of claim 9 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

18. The process of claim 10 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

19. The process of claim 11 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

20. The process of claim 12 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

21. The process of claim 13 wherein
said ions are cations;
said ions have an energy of bombardment is of between about 50-1000 keV; and
said ions are delivered at an ion dose is of at least about 10 15 per cm 2 .

22. The process of claim 6 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

23. The process of claim 10 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

24. The process of claim 11 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

25. The process of claim 12 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

26. The process of claim 13 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

27. The process of claim 21 wherein said ceramic implant is selected from the group consisting of an orthopaedic implant and a dental implant.

28. The process of claim 14 wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorus ions, and combinations thereof.

29. The process of claim 15 wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorus ions, and combinations thereof.

30. The process of claim 16 wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorus ions, and combinations thereof.

31. The process of claim 17 wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorus ions, and combinations thereof.

32. The process of claim 21 wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorus ions, and combinations thereof.

33. The process of claim 3 wherein said ions have an energy is of at least about 50 keV, and said vacuum is less than about 10 −5 torr.

34. A process for increasing the bioactivity of an amorphous or glass-ceramic oxide orthopaedic or dental implant, said process comprising bombarding said implant in a vacuum of less than about 10 −5 torr with at least about 10 15 cations per cm 2 at an energy of at least about 50 keV resulting in a dose sufficient a power density of from about 0 . 1 to about 0 . 5 watts/cm 2 to form a biologically-active calcium hydrocarbonate apatite layer on the surface of said ceramic implant, when said ceramic implant is placed in actual or simulated body fluid, wherein said cations are selected from the group consisting of protons, helium ions, nitrogen ions, calcium ions, phosphorous ions and combinations thereof.

35. A bioactive ceramic implant with increased bioactivity due to treatment of said implant with an ion beam in a vacuum at an energy and a dose sufficient a power density of from about 0 . 1 to about 0 . 5 watts/cm 2 to form a biologically-active calcium hydrocarbonate apatite layer on the surface of said ceramic implant when said ceramic implant is placed in actual or simulated body fluid.

36. The ceramic implant of claim 35 wherein said treatment with an ion beam comprises bombarding said ceramic implant with ions at an energy and at a dose sufficient to maintain the power density is between about 0.1-0.5 watts/cm 2 , and said vacuum is less than about 10 −5 torr.

37. The ceramic implant of claim 35 wherein said ion beam has an energy is of at least about 50 keV, and said vacuum is less than about 10 −5 torr.

38. The process of claim 35 wherein said implant comprises and amorphous or glass-ceramic oxide and said implant is selected from the group consisting of an orthopaedic implant and a dental implant.

39. The ceramic implant of claim 35 wherein said ions in said ion beam are cations.

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