Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors

Abstract

This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: wherein R 22 and R 23 are allyl.

What is claimed is:  
     
       1. A compound of the formula (I):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 11 ;  
       C 2 -C 8  alkenyl substituted with 0-3 R 11 :; 
       C 2 -C 8  alkynyl substituted with 0-3 R 11 ;  
       a C 3 -C 14  carbocyclic ring system substituted with 0-3 R 11  or 0-3 R 12 ;  
       a heterocyclic ring system selected independently from indolyl, furanyl, pyridyl, thienyl, pyrrolyl, benzothienyl, pyrazolyl, thiazolyl, benzofuranyl, tetrahydroisoquinolinvl  tetrahydroisoquinolinyl, benzotriazolyl, benzimidazolyl, or imidazolyl, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       CO 2 R 13 ;  
       R 4A  and R 7A  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 4  alkyl substituted with 0-6 halogen or 0-3 C 1 -C 2  alkoxy;  
       benzyl substituted with 0-6 halogen or 0-3 C 1 -C 2  alkoxy;  
       CO 2 R 13 ;  
       R 4  and R 4A  can alternatively join to form a 5-7 membered carbocyclic ring substituted with 0-2 R 12 ;  
       R 7  and R 7A  can alternatively join to form a 5-7 membered carbocyclic ring substituted with 0-2 R 12 ;  
       n is 1;  
       R 5  is selected from H; , halogen; , C 1 -C 6  alkyl substituted with 0-3 R 11 , —N(R 20 ) 2 , —SR 20 , —OR 20 , or —N 3 ;  
       R 6  is independently selected from: hydrogen, halogen, C 1 -C 6  alkyl substituted with 0-3 R 11 , —N(R 20 ) 2 , —SR 20 , —OR 21 , or —N 3 ;  
       R 5  and R 6  can alternatively join to form an epoxide or aziridine ring; —OCH 2 SCH 2 O—; —OC(═O)O—; —OCH 2 O—; —OC(═S)O—; —OC(═O)C(═O)O—; —OC(CH 3 ) 2 O—; —OC((CH 2 ) 3 NH 2 )(CH 3 )O—; —OC(OCH 3 )(CH 2 CH 2 CH 3 )O—; —OS(═O)O—; —NHC(═O)NH—; —OC(═O)NH—; —NHC(═O)O—; —NHCH 2 O—; —OCH 2 NH—; —NHC(═S)O—; —OS(═O)NH—; —NHC(═O)C(═O)O—; —OC(═O)C(═O)NH—; —NHC(═O)C(═O)NH—; —NHC(CH 3 ) 2 O—; —OC(CH 3 ) 2 NH—;  
       R 5a  is selected from hydrogen, halogen, C 1 -C 6  alkyl, —N(R 20 ) 2 , —SR 20 , or —OR 20 ;  
       R 6a  is selected from: hydrogen, halogen, C 1 -C 6  alkyl, —N(R 20 ) 2 , —SR 20  or —OR21;  
       R 5  and R 5a  can alternatively join to form ═O, ═S, or a ketal ring;  
       R 6  and R 6a  can alternatively join to form ═O, ═S, or a ketal ring;  
       R 20  and R 21  are independently selected from:  
       hydrogen;  
       C 1 -C 6  alkyl substituted with 0-3 R 11 ;  
       C 3 -C 6  alkoxyalkyl substituted with 0-3 R 11 ;  
       C 1 -C 6  alkylcarbonyl substituted with 0-3 R 11 ;  
       C 1 -C 6  alkoxycarbonyl substituted with 0-3 R 11 ;  
       C 1 -C 6  alkylaminocarbonyl substituted with 0-3 R 11 ;  
       benzoyl substituted with 0-3 R 12 ;  
       phenoxycarbonyl substituted with 0-3 R 12 ;  
       phenylaminocarbonyl substituted with 0-3 R 12 ; or  
       phosphate ester;  
       R 11  is selected from one or more of the following:  
       H, keto, halogen, cyano, —CH 2 NR 13 R 14 , —NR 13 R 14 , —CO 2 R 13 , —OC(═O)R 13 , —OR 13 , —S(O) m R 13 , —NHC(═NH)NHR 13 , —C(═NH)NHR 13 , —C(═O)NR 13 R 14 , —NR 14 C(═O)R 13 , ═NOR 14 , —NR 14 C(═O)OR 14 , —OC(═O)NR 13 R 14 , —NR 13 C(═O)NR 13 R 14 , —NR 14 SO 2 NR 13 R 14 , —NR 14 SO 2 R 13 , —SO 2 NR 13 R 14 , —OP(O)(OR 13 ) 2 , C 1 -C 4  alkyl,  C 2 -C 4  alkenyl, C 3 -C 6  cycloalkylmethyl, benzyl, phenethyl, phenoxy, benzyloxy, nitro, C 7 -C 10  arylalkyl, hydroxamic acid, hydrazide, boronic acid, sulfonamide, formyl, C 3 -C 6  cyclolkoxy, C 1 -C 4  alkyl substituted with —NR 13 R 14 ,  cycloalkoxy, C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1  C 4 C 1   -C   4 haloalkyl, C 1 -C 4  haloalkoxy, Cl-c 4  alkoxycarbonyl, pyridylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —OCH 2 CO 2 H, 2-(1-morpholino)ethoxy, azido, or —C(R 14 )═N(OR 14 );  
       1-3 amino acids linked together via amide bonds, said amino acid being linked via the amine or carboxylate terminus;  
       C 3 -C 10  cycloalkyl substituted with 0-2 R 12 ;  
       C 1 -C 4  alkyl substitued  substituted with 0-2 R 12 ;  
       aryl(C 1 -C 3  alkyl)-, substituted with 0-2 R 12 ;  
       C 2 -C 6  alkoxyalkyl-, substituted with 0-2 R 12 ;  
       C 1 -C 4  alkylcarbonyloxy substituted with 0-2 R 12 ,; 
       C 6 -C 10  arylcarbonyloxy substituted with 0-2 R 12 ,; 
       a C 5 -C 14  carbocyclic residue substituted with 0-3 R 12 ;  
       a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-3 R 12 ;  
       R 11A  is selected from one or more of the following:  
       H, keto, halogen, cyano, —CH 2 N(R 13A )R( 14A )  —CH 2   N ( R   13A )( R   14A ), —N(R 13A )R( 14A )  —N( R   13A )( R   14A ), —CO 2 H, —OC(═O)(C 1 -C 3  alkyl), —OH, C 2 -C 6  alkoxyalkyl, —C(═O)NH 2 , —OC(═O)NH 2 , —NHC(═O)NH 2 , —SO 2 NH 2 , C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 3 -C 10  cycloalkyl, C 3 -C 6  cycloalkylmethyl, benzyl, phenethyl, phenoxy, benzyloxy, nitro, C 7 -C 10  arylalkyl, hydroxamic acid, hydrazide, boronic acid, C 3 -C 6  cycloalkoxy, C 1 -C 4  alkyl substituted with —NH 2 , C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —OCH 2 CO 2 H, 2-(1-morpholino)ethoxy, azido, aryl(C 1 -C 3  alkyl), a C 5 -C 14  carbocyclic residue; a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-3 R 12A ;  
       R 12  when a substituent on carbon is selected from one or more of the following: phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, C 1 -C 4  alkoxy, —CO 2 H, hydroxamic acid, hydrazide, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, —OR 13 , C 1 -C 4  alkyl substituted with —NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkylene optionally substituted with —Si(CH 3 ) 3 , C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —S(O) m R 13 , —SO 2 NR 13 R 14 , —NHSO 2 R 14 , —OCH 2 CO 2 R 13 , 2-(1-morpholino)ethoxy, —C(R 14 )═N(OR 14 ); or a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur; or R 12  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, hydroxy, or —NR 13 R 14 ; or, when R 12  is attached to a saturated carbon atom, it may be ═O or ═S; or when R 12  is attached to sulfur it may be ═O;  
       R 12 , when a substituent on nitrogen is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, hydroxy, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, —CH 2 NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxycarbonyl, —CO 2 H, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, —C(R 14 )═N(OR 14 );  
       R 12A , when a substituent on carbon, is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, C 1 -C 4  alkoxy, —CO 2 H, hydroxamic acid, hydrazide, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, —OR 13 , C 1 -C 4  alkyl substituted with —NH 2 , —NH 2 , —NHMe, C 2 -C 6  alkoxyalkyl optionally substituted with —Si(CH 3 ) 3 , C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —S(O) m Me, —SO 2 NH 2 , —NHSO 2 Me, —OCH 2 CO 2 R 13 , 2-(1-morpholino)ethoxy, —C(═NOH)NH 2 ; or  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur;  
       or R 12A  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, hydroxy, or —NH 2 ; or, when R 12A  is attached to a saturated carbon atom, it may be ═O or ═S; or when R 12 R 12A is attached to sulfur it may be ═O. ; 
       R 12A , when a substituent on nitrogen, is selected from one or more of the following: phenyl, benzyl, phenethyl, hydroxy, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, —CH 2 NH 2 , —NH 2 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxycarbonyl, —CO 2 H, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, —C(═NOH)NH 2 ;  
       R 13  is selected from:  
       H;  
       phenyl substituted with 0-3 R 11A ;  
       benzyl substituted with 0-3 R 11A ;  
       C 1 -C 6  alkyl substituted with 0-3 R 11A ;  
       C 2 -C 4  alkenyl substituted with 0-3 R 11A ;  
       C 1 -C 6  alkylcarbonyl substituted with 0-3 R 11A ;  
       C 1 -C 6  alkoxycarbonyl substituted with 0-3 R 11A ;  
       C 1 -C 6  alkylaminocarbonyl substituted with 0-3 R 11A ;  
       C 3 -C 6  alkoxyalkyl substituted with 0-3 R 11A ;  
       R 14  is hydrogen, hydroxy, C 1 -C 6  alkyl substituted with 0-3 groups selected from OH, C 1 -C 4  alkoxy, and halogen, ; NH 2 , —NH(C 1 -C 4  alkyl),C 1 -C 6 C 1 -C 4  alkoxy, C 2 -C 6 C 2 -C 4   alkenyl, phenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 13A  and R 14A  are independently selected from: H, C 1 -C 6  alkyl;  
       R 13A  and R 14A  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 15  is H or CH 3 ;  
       m is 0, 1 or 2;  
       W is selected from:  
       —N(R 22 )C(═Z)N(R 23 )—;  
       —N(R 22 )S(═Z′)N(R 23 )—;  
       —N(R 22 )S(═Z′) 2 N(R 23 )—;  
       —N(R 22 )P(═O)(R 24a )N(R 23 )—;  
       wherein: 
       Z is O, S, NR 24 ;  
       Z′ is O or NR 24 ;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen; —OR 22a ; —N(R 22a )(R 22b );  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkenyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkynyl substituted with 0-3 R 31 ;  
       a C 3 -C 14  carbocyclic ring system substituted with 0-5 R 31  or 0-5 R 32 ;  
       a heterocyclic ring system selected independently from pyridinyl, pyrimidinyl, pyrazolyl, imidazolyl, tetrazoyl, triazinyl, pyrazinyl, myridazinyl  pyridazinyl, oxazolidinyl, and thiazolyl said heterocyclic ring system being substituted with 0-2 R 32 ;  
       R 22a  and R 22b  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkenyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkynyl substituted with 0-3 R 31 ;  
       a C 3 -C 14  carbocyclic ring system substituted with 0-5 R 31  or 0-5 R 32 ;  
       a heterocyclic ring system selected independently from pyridinyl, furanyl, thienyl, pyrrolyl, thiazolyl, pyrazolyl, imidazolyl, indolyl, benzimidazolyl, 1H-indazolyl, oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl, or isatinoyl said heterocyclic ring system being substituted with 0-2 R 32 ;  
       R 24  is selected from: hydrogen; hydroxy; amino; C 1 -C 4  alkyl; C 1 -C 4  alkoxy; mono- or di-(C 1 -C 6  alkyl)amino; cyano; nitro; benzyloxy; —NHSO 2 aryl, aryl being optionally substituted with (C 1 -C 6 )alkyl;  
       R 24a  is selected from: hydroxy; amino; C 1 -C 4  alkyl; C 1 -C 4  alkoxy; mono- or di-(C 1 -C 6  alkyl)amino; cyano; nitro; benzyloxy; or phenoxy;  
       alternatively, R 22  can join with R 4  or R 4A  to form a 5- or 6-membered fused heterocyclic ring or carbocyclic ring substituted with 0-2 R 12 , said heterocyclic ring selected from pyrrolidine, morpholine, thiomorpholine, piperidine, or piperazine; or  
       alternatively, R 23  can join with R 7  or R 7A  to form a 5- or 6-membered fused heterocyclic ring or carbocyclic ring substituted with 0-2 R 12 , said heterocyclic ring selected from pyrrolidine, morpholine, thiomorpholine, piperidine, or piperazine; or  
       alternatively, R 22  or R 23  can join with R 5  or R 6  to form a 0- to 7-membered bridge to form a carbocyclic or heterocyclic ring, said bridge being substituted with 0-2 R 12  and said heterocyclic ring being selected from pyrrolidine, morpholine, thiomorpholine, piperidine, or piperazine;  
       alternatively R 23  can join with R 7A  to form a direct bond;  
       alternatively R 22  can join with R 4A  to form a direct bond;  
       R 31  is selected from one or more of the following:  
       keto, halogen, cyano, —CH 2 NR 13 R 14 , —NR 13 R 14 , —CO 2 R 3 —CO 2   R   13 , —C(═O)R 11 , —OC(═O)R 13 , —OR 13 , C 2 -C 6  alkoxyalkyl, —S(O) m R 13 , —NHC(═NH)NHR 13 , —C(═NH)NHR 13 , —C(═O)NR 13 R 14 , —NR 14 C(═O)R 13 , ═NOR 14 , —NR 14 C(═O)OR 14 , —OC(═O)NR 13 R 14 , —NR 13 C(═O)NR 13 R 14 , —NR 13 C(═S)NR 13 R 14 , —NR 14 SO 2 NR 13 R 14 , —NR 14 SO 2 R 13 , —SO 2 NR 13 R 14 , C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 3 -C 10  cycloalkyl, C 3 -C 6  cycloalkylmethyl, benzyl, phenethyl, phenoxy, benzyloxy, nitro, C 7 -C 10  arylalkyl, hydroxamic acid, hydrazide, oxime, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, C 1 -C 4  alkyl substituted with —NR 13 R 14 , C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —OCH 2 CO 2 R 13 , 2-(1-morpholino)ethoxy, azido, —C(R 14 )═N(OR 14 ); or  
       1-3 amino acids, linked together via amide bonds, said amino acid being linked via the amine or carboxylate terminus;  
       a C 5 -C 14  carbocyclic residue substituted with 0-5 R 32 ; or  
       a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-2 R 32 ;  
       R 32 , when a substituent on carbon, is selected from one or more of the following:  
       phenethyl, phenoxy, C 3 -C 10  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, hydrazide, oxime, boronic acid, C 2 -C 6  alkoxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  alkylcarbonyloxy, —NHSO 2 R 14 , benzyloxy, halogen, 2-(1-morpholino) ethoxy, —CO 2 R 13 , hydroxamic acid, —CONR 13 NR 13 R 14 , cyano, sulfonamide, —CHO, C 3 -C 6  cycloalkoxy, —NR 13 R 14 , —C(R 14 )═N(OR 14 ), —NO 2 , —OR 13 , —NR 40 R 41 , —SO m R 13 , —SO m NR 13 R 14 , —C(═O)NR 13 R 14 , —OC(═O)NR 13 R 14 , —C(═O)R 11 , —OC(═O)R 11 , —OCO 2 R 13 , phenyl, —C(═O)NR 13 —(C 1 -C 4  alkyl)-NR 13 R 14 , —C(═O)NR 40 R 41 , C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 2 -C 4  haloalkenyl, C l -C 4  haloalkynyl  C 2   -C   4    haloalkynyl , or  
       —C(═O)NR 13 C(R 11 ) 2 NR 13 R 14 :  
       —C(═O)NR 13 C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)NR 13 —(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ;  
       —C(═O)N(R 13 )—(C 1 -C 4  alkyl)-R 11 ; or  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       C 1 -C 4  alkoxy substituted with 0-4 groups selected from:  
       R 11 , C 3 -C 6  cycloalkyl, —CO 2 R 13 , —C(═O)NR 13 R 14 , —NR 13 R 14 or OH ;  
       C 1 -C 4  alkyl substituted with 0-4 groups selected from:  
       R 11 , ═NR 14 , ═NNR 13 C(═O)NR 13 R 14 , ═NNR 13 C(═O)OR 13 , or —NR 13 R 14 ;  
       C 2 -C 4  alkenyl substituted with 0-4 R 11 ;  
       C 2 -C 4  alkynyl substituted with 0-4 R 11 ;  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, substituted with 0-2 R 12 ;  
       or R 32  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, hydroxy, or —NR 13 R 14 ; or, when R 32  is attached to a saturated carbon, it may be ═O, ═S, ═NOH; or when R 32  attached to sulfur it may be ═O. ; 
       R 32 , when a substituent on nitrogen, is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, hydroxy, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, —CH 2 NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxycarbonyl, —CO 2 H, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, —C(R 14 )═N(OR 14 );  
       R 40  is selected from: H, C 1 -C 3  alkyl;  
       R 41  is selected from:  
       —C(═O)NR 13 R 14 ;  
       —C(═O)NR 13 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)H;  
       —C(═O)R 11 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═C)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ;  
       1-3 amino acids linked together via amide bonds, and linked to the N atom via the carboxylate terminus;  
       wherein said aryl group is phenyl or naphthyl;  
       provided that:  
       R 4 , R 4A , R 7  and R 7A  are not all hydrogen;  
       when R 4  and R 4A  are hydrogen, R 22  is not hydrogen.  
     
     
       2. A compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein: 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 11 ;  
       C 2 -C 8  alkenyl substituted with 0-3 R 11 ;  
       C 2 -C 8  alkynyl substituted with 0-3 R 11 ;  
       C 3 -C 8  cycloalkyl substituted with 0-3 R 11 ;  
       C 6 -C 10  bicycloalkyl substitutd with 0-3 R 11 ;  
       aryl substituited with 0-3 R 12 ;  
       a C 6 -C 14  partially unsaturated carbocyclic residue substituted with 0-3 R 12 ;  
       a heterocyclic ring system selected independently from indolyl, furanyl, pyridyl, thienyl, pyrrolyl, pyrazolyl, thiazolyl, or imidazolyl, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkenyl substituted with 0-3 R 31 ;  
       C 2 -C 8  alkynyl substituted with 0-3 R 31 ;  
       C 3 -C 8  cycloalkyl substituted with 0-3 R 31 ;  
       C 6 -C 10  bicycloalkyl substituted with 0-3 R 31 ;  
       aryl substituted with 0-5 R 32 ;  
       a C 6 -C 14  partially unsaturated carbocyclic residue substituted with 0-3 R 32 ;  
       a heterocyclic ring system selected independently from pyridinyl, pyrimidinyl pyrazolyl, imidazolyl, tetrazoyl, triazinyl, pyrazinyl, pyridazinyl, oxazolidinyl, and thiazolyl said heterocyclic ring system being substituted with 0-2 R 32 .  
     
     
       3. A compound of  claim 1 , of formula (I):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 4  alkyl substituted with 0-3 R 11 ;  
       C 3 -C 4  alkenyl substituted with 0-3 R 11 ;  
       C 3 -C 4  alkynyl substituted with 0-3 R 11 ;  
       R 4A  and R 7 A are hydrogen;  
       n is 1;  
       R 5  is selected from fluoro, —OR 20 , —N(R 20 ) 2 ;  
       R 6  is independently selected from: hydrogen, fluoro or —OR 21 ;  
       R 5  and R 6  can alternatively join to form an epoxide or aziridine ring; —OCH 2 SCH 2 O—; —OS(═O)O—; —OC(═O)O—; —OCH 2 O—; —OC(═S)O—; —OC(═O)C(═O)O—; —OC(CH 3 )2O—  —OC( CH   3 ) 2   O—;  —OC(OCH 3 )(CH 2 CH 2 CH 3 )O—;  
       R 5a  is selected from hydrogen or fluoro;  
       R 6a  is selected from: hydrogen or fluoro;  
       R 5  and R 5a  can alternatively join to form ═O, ═S, or a ketal ring;  
       R 6  and R 6a  can alternatively join to form ═O, ═S, or a ketal ring;  
       R 20  and R 21  are independently selected from:  
       hydrogen;  
       C 1 -C 6  alkylcarbonyl;  
       C 1 -C 6  alkoxycarbonyl;  
       benzoyl; or  
       phosphate ester;  
       R 11  is selected from one or more of the following:  
       H, keto, halogen, cyano, —CH 2 NR 13 R 14 , —NR 13 R 14 , —CO 2 R 13 , —OC(═O)R 13 , —OR 13 , C 2 -C 4  alkoxyalkyl, —S(O) m R 13 , C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 3 -C 10  cycloalkyl;  
       a C 5 -C 14  saturated or partially unsaturated carbocyclic residue substituted with 0-3 R 12 ;  
       aryl(C 1 -C 3  alkyl)-, substituted with 0-2 R 12 ;  
       aryl substituted with 0-3 R 12 ; or  
       a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       R 12  when a substituent on carbon is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, C 1 -C 4  alkoxy, 2-(1-morpholino)ethoxy, —CO 2 H, hydroxamic acid, hydrazide, —C(R 14 )═N(OR 14 ), cyano,  boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, —OR 13 , C 1 -C 4  alkyl substituted with —NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —S(O) m R 13 , —SO 2 NR 13 R 14 , —NHSO 2 R 14 ; or  
       a 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur;  
       or R 12  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, hydroxy, or —NR 13 R 14 ; or, when R 12  is attached to a saturated carbon atom, it may be ═O or ═S; or when R 12  is attached to sulfur it may be ═)  ═O;  
       R 12 , when a substituent on nitrogen, is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, hydroxy, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, —CH 2 NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, —CO 2 H;  
       R 13  is H, C 1 -C 6  alkyl, C 3 -C 6  alkoxyalkyl, C 2 -C 4  alkenyl, phenyl, or benzyl;  
       R 14  is OH, H, CF 3 , C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , C 2 -C 4  alkenyl, phenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 15  is H or CH 3 :; 
       m is 0, 1 or 2;  
       W is selected from:  
       —N(R 22 )C(═Z)N(R 23 )—;  
       —N(R 22 )S(═Z′)N(R 23 )—;  
       —N(R 22 )S(═Z′) 2 N(R 23 )—;  
       —N(R 22 )P(═O)(R 24a )N(R 23 )—;  
       wherein: 
       Z is O, S, N—CN, N—OH, N—OCH 3 ;  
       Z′ is oxygen: ; 
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 3 -C 8  alkenyl substituted with 0-3 R 31 ;  
       C 3 -C 8  alkynyl substituted with 0-3 R 31 ;  
       C 3 -C 6  cycloalkyl substituted with 0-3 R 31 ;  
       R 24a  is selected from —OH, C 1 -C 4  alkoxy, mono- or di-(C 1 -C 6  alkyl)amino;  
       R 31  is selected from one or more of the following:  
       keto, halogen, cyano, —CH 2 NR 13 RI 4 , —NR 13 R 14 , —CO 2 R 13 , —OC(═O)R 13 , —OR 13 , C 2 -C 4  alkoxyalkyl, —S(O) m R 13 , C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 3 -C 10  cycloalkyl, benzyl, phenethyl, phenoxy, benzyloxy, nitro, C 7 -C 10  arylalkyl, hydroxamic acid, hydrazide, oxime, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, C 1 -C 4  alkyl substituted with —NR 13 R 14 , C 1 -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, —OCH 2 CO 2 H, 2-(1-morpholino)ethoxy, —C(R 14 )═N(OR 14 ); or  
       a C 5 -C 14  saturated or partially unsaturated carbocyclic residue substituted with 0-3 R 32 ;  
       aryl substituted with 0-3 R 32 ; or  
       a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-2 R 32 ;  
       R 32 , when a substituent on carbon, is selected from one or more of the following: phenethyl, phenoxy, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, hydrazide, oxime, boronic acid, C 2 -C 6  alkoxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  alkylcarbonyloxy, —NHSO 2 R 14  benzyloxy, halogen, 2-(1-morpholino)ethoxy, —CO 2 R 13 , hydroxamic acid, —CONR 13 NR 13 R 14 , cyano, boronic acid,  sulfonamide, —CHO, C 3 -C 6  cycloalkoxy, —NR 13 R 14 , —C(R 14 )═N(OR 14 ), NO 2 , —OR 13 , —NR 40 R 41 , —SO m R 13 , —SO m NR 13 R 14 , —C(═O)NR 13 R 14 , —OC(═O)NR 13 R 14 , —C(═O)R 11 ,  
       —OC(═O)R 11 , —OCO 2 R 13 , phenyl,  
       —C(═O)NR 13 —(C 1 -C 4  alkyl)NR 13 R 14 , —C(═O)NR 40 R 41 , C 1 -C 4  haloalkyl,  
       C 1 -C 4  haloalkoxy, C 2 -C 4  haloalkenyl, C 2 -C 4  haloalkynyl, or  
       —C(═O)NR 13 C(R 11 ) 2 NR 13 R 14 ; —C(═O)NR 13 C(R 11 ) 2 NR 13 NR 14 ;   
       —C(═O)NR 13 C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)NR 13 —(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ; —C(═O)C(R 11 ) 2 NR 13 NR 14 ;   
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       C 1 -C 4  alkoxy substituted with 0-3 groups selected from:  
       R 11 , C 3-C   6  cycloalkyl, —CO 2 R 13 , —C(═O)NR 13 R 14 , —NR 13 R 14 or OH ;  
       C 1 -C 4  alkyl substituted with 0-3 groups selected from:  
       R 11 , ═NR 14 , ═NNR 13 C(═O)NR 13 R 14  or —NR 13 R 14 ;  
       C 2 -C 4  alkenyl substituted with 0-3 R 11 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 11 ;  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, substituted with 0-2 R 12 ;  
       or R 32  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, hydroxy, or —NR 13 R 14 ; or, when R 32  is attached to a saturated carbon atom, it may be ═O or ═S; or when R 12 R 32  is attached to sulfur it may be ═O. ; 
       R 32 , when a substituent on nitrogen, is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, hydroxy, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, —CH 2 NR 13 R 14 , —NR 13 R 14 , C 2 -C 6  alkoxyalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxycarbonyl, C 1 -C 4  alkylcarbonyloxy, C 1 -C 4  alkylcarbonyl, —CO 2 H, —C(R 14 )═N(OR 14 );  
       R 40  is selected from: H, C 1 -C 3  alkyl;  
       R 41  is selected from;  
       —C(═O)NR 13 R 14 ;  
       —C(═O)NR 13 NR 14 —C( ═O ) NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 —C( ═O ) C ( R   11 ) 2   NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)H;  
       —C(═O)R 11 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ;  
       1-3 amino acids linked together via amide bonds, and linked to the N atom via the carboxylate terminus;  
       wherein said aryl group is phenyl or naphthyl;  
       provided that:  
       R 4 , R 4A , R 7 , and R 7A  are not all hydrogen; when R 4  and R 4A  are hydrogen, then R 22  is not hydrogen.  
     
     
       4. A compound of  claim 1 , of formula (II):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 4  alkyl substituted with 0-3 R 11 ;  
       C 3 -C 4  alkenyl substituted with 0-3 R 11 ;  
       R 5  is —OR 20 ;  
       R 6  is hydrogen or —OR 21 ;  
       R 20  and R 21  are H;  
       R 11  is selected from one or more of the following:  
       H, keto, halogen, —CH 2 NR 13 R 14 , —NR 13 R 14 , —OR 13 , C 2 -C 4  alkoxyalkyl, C 2 -C 4  alkenyl, ; 
       C 3 -C 10  cycloalkyl substituted with 0-2 R 12 ;  
       C 1 -C 4  alkyl substituted with 0-2 R 12 ;  
       aryl(C 1 -C 3  alkyl)-, substituted with 0-2 R 12 ;  
       aryl substituted with 0-3 R 12 ; or  
       a 5- or 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       R 12 , when a substituent on carbon, is selected from one or more of the following:  
       phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, C 1 -C 4  alkyl, C 7 -C 10  arylalkyl, C 1 -C 4  alkoxy, 2-(1-morpholino)ethoxy, —CO 2 H, hydroxamic acid, hydrazide, —C(R 14 )═N(OR 14 ), cyano, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, —OR 13 , C 1 -C 4  alkyl substituted with —NR 13 R 14 , —NR 13 R 14 , methylenedioxy, C 1 -C 4  haloalkyl, C 1 -C 4  alkylcarbonyl, C 1 -C 4  alkylcarbonylamino, hydroxy, hydroxymethyl; or  
       a 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur;  
       R 12 , when a substituent on nitrogen, is selected from benzyl or methyl;  
       R 13  is H, C 1 -C 4  alkyl, C 3 -C 6  alkoxyalkyl, C 2 -C 4  alkenyl, or benzyl;  
       R 14  is OH, H, CF 3 , C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , C 2 -C 4  alkenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 15  is H or CH 3 ;  
       W is selected from:  
       —N(R 22 )C(═Z)N(R 23 )—;  
       —N(R 22 )S(═Z′)N(R 23 )—;  
       —N(R 22 )S(═Z′) 2 N(R 23 )—;  
       —N(R 22 )P(═O)(R 24 a)N(R 23 )— —N( R   22 ) P ( ═O )( R   24a ) N ( R   23 )—;  
       wherein: 
       Z is O, S, or N—CN;  
       Z′ is 0;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-2 R 31 ;  
       C 2 -C 6  alkenyl substituted with 0-1 R 31 ;  
       C 2 -C 4  alkynyl substituted with 0-1 R 31 ;  
       R 24a  is selected from —OH, C 1 -C 4  alkoxy, mono- or di-(C 1 -C 6  alkyl)amino;  
       R 31  is selected from one or more of the following:  
       keto, halogen, —CH 2 NR 13 R 14 , —NR 13 R 14 , —OR 13 , C 2 -C 4  alkoxyalkyl, C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 3 -C 10  cycloalkyl, —C(R 14 )═N(OR 14 ), —CO 2 R 13 , —S(O) m R 13 ;  
       aryl substituted with 0-5 R 32 ; or  
       a 5- to 10-membered heterocyclic ring system containing 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, said heterocyclic ring system being substituted with 0-2 R 32 ;  
       R 32 , when a substituent on carbon, is selected from one or more of the following:  
       phenethyl, phenoxy, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylmethyl, C 7 -C 10  arylalkyl, hydrazide, oxime, boronic acid, C 2 -C 6  alkoxyalkyl, methylenedioxy, ethylenedioxy, C 1 -C 4  alkylcarbonyloxy, —NHSO 2 R 14 , benzyloxy, halogen, 2-(1-morpholino) ethoxy, —CO 2 R 13 , hydroxamic acid, —CONR 13 NR 13 R 14 , cyano, boronic acid,  sulfonamide, —CHO, C 3 -C 6  cycloalkoxy, —NR 13 R 14 , —C(R 14 )═N(OR 14 ), NO 2 , —OR 13 , —NR 40 R 41 , —SO m R 13 , —SO m NR 13 R 14 , —C(═O)NR 13 R 14 , —OC(═O)NR 13 R 14 , —C(═O)R 11 , —OC(═O)R 11 , —OCO 2 R 13 , phenyl, —C(═O)NR 13 —(C 1 —C 4  alkyl)—NR 13 R 14 , —C(═O)NR 40 R 41 , C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 2 -C 4  haloalkenyl, C 2 -C 4  haloalkynyl, or  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)—(C 1 -C 4  alkyl)—NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)—NR 13 CO 2 R 13 ; or  
       C 1 -C 4  alkoxy substituted with 0-3 groups selected from:  
       R 11 , C 3 -C 6  cycloalkyl, —CO 2 R 13 , —C(═O)NR 13 R 14 , —NR 13 R 14  or OH ;  
       C 1 -C 4  alkyl substituted with 0-3 groups selected from:  
       R 11 , —NR 14 , ═NNR 13 C(═O)NR 13 R 14  or —NR 13 R 14 ;  
       C 2 -C 4  alkenyl substituted with 0-3 R 11 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 11 ;  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, substituted with 0-3 R 12 ;  
       R 32 , when a substituent on nitrogen, is selected from benzyl or methyl;  
       m is 0, 1, or 2;  
       R 40  is selected from: H, C 1 -C 3  alkyl;  
       R 41  is selected from:  
       —C(═O)NR 13 R 14 ;  
       —C(═O)NR 13 NR 14 —C( ═O ) NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 —C( ═O ) C ( R   11 ) 2   NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)H;  
       —C(═O)R 11 ;  
       —C(═O)—(C 1 —C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 —C 4  alkyl)—NR 13 CO 2 R 13 ;  
       1-3 amino acids linked together via amide bonds, and linked to the N atom via the carboxylate terminus;  
       wherein said aryl group is phenyl or naphthyl; 
       provided that: 
       R 4  and R 7  are not both hydrogen;  
       when R 4  is hydrogen, then R 22  is not hydrogen.  
     
     
       5. A compound of  claim 4 , or a pharmaceutically acceptable salt form thereof, wherein: 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 3  alkyl substituted with 0-1 R 11 ;  
       R 5  is —OR 20 ;  
       R 6  is hydrogen or —OR 21 ;  
       R 20  and R 21  are H;  
       R 11  is selected from one or more of the following:  
       H; halogen; —OR 13 ;  
       C 3 -C 10  cycloalkyl substituted with 0-2 R 12 ;  
       C 1 -C 4  alkyl substituted with 0-2 R 12 ;  
       aryl (C 1 -C 3  alkylene) substituted with 0-2 R 12 ;  
       aryl substituted with 0-2 R 12 ; or  
       a heterocyclic ring system selected from pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, oxazolidinyl, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       R 12 , when a substituent on carbon is selected from one or more of the following:  
       benzyloxy, halogen, methyl, C 1 -C 4  alkoxy, CF 3 , 2-(1-morpholino)ethoxy, —CO 2 H, hydroxamic acid, hydrazide, —C(R 14 )═N(OR 14 ), cyano, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, C 1 -C 4  alkyl substituted with —NR 13 R 14 , —NR 13 R 14 , hydroxy, hydroxymethyl; or  
       R 12 , when a substituent on nitrogen, is methyl;  
       R 13  is H, C 1 -C 4  alkyl, C 2 -C 4  alkenyl, or benzyl;  
       R 14  is OH, H, CF 3 , C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , C 2 -C 4  alkenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 , or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 15  is H or CH 3 ;  
       W is selected from:  
       —N(R 22 )C(═Z)N(R 23 )—;  
       —N(R 22 )C(═Z)O—;  
       —N(R 22 )S(═Z′) 2 N(R 23 )—;  
       Z is O, S, or N—CN;  
       Z′ is O;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 2 -C 6  alkenyl substituted with 0-3 R 31 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 31 ;  
       R 31  is selected from one or more of the following:  
       halogen, —OR 13 , C 1 -C 4  alkyl, C 3 -C 10  cycloalkyl, —C(R 14 )═N(OR 14 ), —CO 2 R 13 , —S(O) m R 13 ;  
       aryl substituted with 0-5 R 32 ; or  
       a heterocyclic ring system chosen from pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, oxazolidinyl, said heterocyclic ring being substituted with 0-2 R 32 ;  
       R 32 , when a substituent on carbon, is selected from one or more of the following:  
       benzyloxy, halogen, 2-(1-morpholino)ethoxy, —CO 2 R 13 , hydroxamic acid, —CONR 13 NR 13 R 14 , cyano, boronic acid, sulfonamide, —CHO, C 3 -C 6  cycloalkoxy, —NR 13 R 14 , —C(R 14 )═N(OR 14 ), NO 2 , —OR 13 , —NR 40 R 41 , —SO m R 13 , —SO m NR 13 R 14 , —C(═O)NR 13 R 14 , —OC(═O)NR 13 R 14 , —C(═O)R 11 , —OC(═O)R 11 , —OCO 2 R 13 , phenyl, —C(═O)NR 13 —(C 1 -C 4  alkyl)-NR 13 R 14 , —C(═O)NR 40 R 41 , C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 2 -C 4  haloalkenyl, C 2 -C 4  haloalkynyl, —C(═O)NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       C 1 -C 4  alkoxy substituted with 0-3 groups selected from:  
       R 11 , C 3 -C 6  cycloalkyl, —C(═O)NR 13 R 14 , —NR 13 R 14 or OH ;  
       C 1 -C 4  alkyl substituted with 0-3 groups selected from:  
       R 11 , ═NR 14 , ═NNR 13 C(═O)NR 13 R 14  or —NR 13 R 14 ;  
       C 2 -C 4  alkenyl substituted with 0-3 R 11 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 11 ;  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur, substituted with 0-2 R 12 ;  
       R 32 , when a substituent on nitrogen, is methyl;  
       m is 0, 1, or 2;  
       R 40  is selected from: H, C 1 -C 3  alkyl;  
       R 41  is selected from:  
       —C (═O) NR 13 R 14 ;  
       —C(═O)NR 13 NR 14 —C( ═O ) NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 —C( ═O ) C ( R   11 ) 2   NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)H;  
       —C(═O)R 11 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ;  
       1-3 amino acids linked together via amide bonds, and linked to the N atom via the carboxylate terminus;  
       wherein said aryl group is phenyl or naphthyl; 
       provided that: 
       R 4  and R 7  are not both hydrogen;  
       when R 4  is hydrogen, then R 22  is not hydrogen.  
     
     
       6. A compound of  claim 1 , or a pharmaceutically acceptable salt form thereof, wherein: 
       R 4  and R 7  are selected from benzyl, fluorobenzyl, methylbenzyl, dimethylbenzyl, ethylbenzyl, pyrrolylmethyl, methoxybenzyl, isobutyl, nitrobenzyl, aminobenzyl, thienylmethyl, hydroxybenzyl, pyridylmethyl, or naphthylmethyl;  
       R 5  is —OH;  
       R 6  is hydrogen or —OH;  
       R 13  is H, C 1 -C 4 C 1   -C   4  alkyl, C 2 -C 4  alkenyl, or benzyl;  
       R 14  is OH, H, CF 3 , C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , C 2 -C 4  alkenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       W is selected from:  
       —N(R 22 )C(═O)N(R 23 )—;  
       —N(R 22 )C(═N—CN)N(R 23 )—;  
       —N(R 22 )S(═O) 2 N(R 23 )—;  
       —N(R 22 )C(═S)N(R 23 )—;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-2 R 31 ;  
       C 2 -C 6  alkenyl substituted with 0-2 R 31 ;  
       C 2 -C 4  alkynyl substituted with 0-2 R 31 ;  
       R 31  is selected from one or more of the following:  
       halogen, —OR 13 , C 1 -C 4  alkyl, C 3 -C 10  cycloalkyl, —C(R 14 )═N(OR 14 ), —CO 2 R 13 , —S(O) m R 13 ;  
       aryl substituted with 0-5 R 32 ; or  
       a heterocyclic ring system chosen from pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, oxazolidinyl, benzimidazolyl, benzotriazolyl, indazolyl, benzoxazolinyl, benzoxazolyl, said heterocyclic ring being substituted with 0-2 R 32 ;  
       R 32  when a substituent on carbon, is selected from one or more of the following:  
       —CONH 2 , —CO 2 H, —CHO, —CH 2 NHOH, —CH 2 NR 13 R 14 , —NR 13 R 14 , hydroxy, hydroxymethyl, —C(R 14 )═N(OR 14 ), halogen, methoxy, methyl, nitro, cyano, allyloxy, —CO 2 CH 3 , —NHCHO, —NHCOCH 3 , —OCO 2 CH 3 , —CH═NCH 2 CH 2 OH, —OCONHCH 2 C 6 H 5 , —OCONHCH 3 , oxazolidinyl, —C≡C—CH 2 OH, —COCH 3 , hydroxyethyl, C 1 -C 3  alkyl (said alkyl substituted with 0-4 halogen, or OH), tetrazolyl, —OCH 2 CONH 2 , CONHNH 2 ,  —CH═NNHCONH 2 , —CONHOCH 3 ,  —CH 2 CH(OH)CH 2 OH, adamantamido, hydroxyethoxy, dihydroxyethyl, —C(NH 2 )═NH, —CONHCH 3 ,  —B(OH) 2 , benzyloxy, —CONHCH 2 CH 3 , —CON(CH 2 CH 3 ) 2 ,  methylthio, —SO 2 CH 3 , —NHCONH 2 , —NHCONHCH 3 , —NHCOCH 2 N(CH 3 ) 2 , —NHCOCH 2 NHCH 3 , —NHCOCH 2 NHCO 2 CH 2 C 6 H 5 , —NHCOCH 2 NH 2 , —NHCOCH(CH 3 )NHCO 2 CH 2 C 6 H 5 , —NHCOCH(CH 2 C 6 H 5 )NHCO 2 CH 2 C 6 H 5 , —NHCOCH(CH 3 )NH 2 , —NHCOCH(CH 2 C 6 H 5 )NH 2 , —CO 2 CH 2 CH 3 , —CONHCH 2 CH 2 CH 3 , —CONHCH(CH 3 ) 2 ,  —CH 2 -imidazole, —COC(CH 3 ) 3 , —CH(OH)CF 3 , —CO-imidazole, —CO-pyrazolyl, —CO—CH 2 -pyridine, oxidiazolyl,  —COCF 3 , —C(CH 2 CH 3 )═N(OH)or , —C(CF 3 )═N(OH), phenyl, acetoxy, hydroxyamino, —N(CH 3 )(CHO), cyclopropylmethoxy, —CONR 13 R 14 , —CONHOH,  diethylaminoethyl)aminocarbonyl, (N-ethyl, N-methlaminoethyl) aminocarbonyl  ( N - ethyl,N - methylaminoethyl ) aminocarbonyl,  (4-methylpiperazinylethyl)aminocarbonyl, (pyrrolidinylethyl)aminocarbonyl, (piperidinylethyl)aminocarbonyl, —NHCOCH 2 NHCH 3 ,  N-(2-(4-morpholino)ethyl)aminocarbonyl, N-(2-N,N-dimethylamino)ethyl)aminocarbonyl, wherein said oxazolidinyl, tetrazolyl, oxadiazolyl, imidazolyl, pyrazolyl, pyrrolidinyl, and piperidinyl groups are optionally substituted with 1-2 groups independently selected from OH, —O(C 1 -C 3  alkyl), NH 2 , —NH(C 1 -C 3  alkyl), or halogen;  
       R 32 , when a substituent on nitrogen, is methyl.  
     
     
       7. A compound of  claim 1  or a pharmaceutically acceptable salt form thereof, of the formula:                    
       wherein: 
       Z is O, S, or N—CN; 
       R 4  and R 7  are independently selected from: benzyl, methylbenzyl, dimethylbenzyl, ethylbenzyl, fluorobenzyl, pyrrolylmethyl, methoxybenzyl, isobutyl, nitrobenzyl, aminobenzyl, thienylmethyl, hydroxybenzyl, pyridylmethyl, or naphthylmethyl;  
       R 22  and R 23  are independently selected from the group consisting of:  
       hydrogen, allyl, methyl, ethyl, propyrl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C(CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH) -benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (CH 3 C(═NOH) )-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHN═CH)-benzyl, (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)benzyl, hydroxyethoxybenzyl(oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethylbenzyl, N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl) alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxypentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, CHBNHC(═O)O)benzyl  ( CH   3   NHC ( ═O ) O ) benzyl , (NH 2 C(═O)CH 2 O)benzyl, (NH 2 C(═NH))benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbenzyl, aminoimidozolylbenzyl  aminoimidazolylbenzyl.  
     
     
       8. A compound of  claim 1  of formula (IIa):                    
       or a pharmaceutically acceptable salt form thereof, wherein: 
       wherein R 22  and R 23  are independently selected from the group consisting of:  
       hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C(CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH) -benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (CH 3 C(═NOH))-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHN═CH)-benzyl, (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethylbenzyl, N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl—C(═O))-benzyl, (pyrazolyl—C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxypentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, (CH 3 NHC(═O)O)benzyl, (NH 2 C(═O)CH 2 O)benzyl, (NH 2 C(═NH))benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbenzyl, aminoimidazolylbenzyl.  
     
     
       9. A compound of  claim 1  of formula (IIa):                    
       or a pharmaceutically acceptable salt form thereof, selected from the group consisting of: 
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is allyl;  
       the compound of formula (IIa) wherein R 22  is propyl and R 23  is propyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is n-hexyl and R 23  is n-hexyl;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is n-butyl;  
       the compound of formula (IIa) wherein R 22  is CH 2 CH═C(CH 3 ) 2  and R 23  is CH 2 CH═C(CH 3 ) 2 ;  
       the compound of formula (IIa) wherein R 22  is CH 2 CH═C(CH 3 ) 2  and R 23  is H;  
       the compound of formula (IIa) wherein R 22  is i-pentyl and R 23  is i-pentyl;  
       the compound of formula (IIa) wherein R 22  is 2-methallyl and R 23  is 2-methallyl;  
       the compound of formula (IIa) wherein R 22  is n-pentyl and R 23  is n-pentyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is i-hexyl and R 23  is i-hexyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is isoprenyl;  
       the compound of formula (IIa) wherein R 22  is 1-cinnamyl and R 23  is 1-cinnamyl;  
       the compound of formula (IIa) wherein R 22  is 4-fluorobenzyl and R 23  is 4-fluorobenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is CH 2 CH═C(CH 3 ) 2  and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is 2-naphthylmethyl and R 23  is 2-napthylmethyl;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is CH 2 CH═C(CH 3 ) 2  and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is ethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is 4-pyridinylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 4-pyridinylmethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is n-propyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is cinnamyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopentylmethyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 2-pyridinylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-cyanobenzyl and R 23  is 3-cyanobenzyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is n-propyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is hydrogen and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 4-pyridinylmethyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIa) wherein R 22  is allyl and R 23  is 2-quinolinylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-pyridinylmethyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-pyridinylmethyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxybenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is vinylbenzyl and R 23  is vinylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-allyloxybenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-pyridinylmethyl and R 23  is 3-pyridinylmethyl;  
       the compound of formula (IIa) wherein R 22  is 2-naphthylmethyl and R 23  is 4-fluorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxybenzyl and R 23  is 4-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-carbomethoxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-formylbenzyl and R 23  is 3-formylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-cyanobenzyl and R 23  is 4-cyanobenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-formylbenzyl and R 23  is 4-formylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxybenzyl and R 23  is 2-propyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxybenzyl and R 23  is 2-propyl;  
       the compound of formula (IIa) wherein R 22  is 3-carboxybenzyl and R 23  is 3-carboxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-formaldoximebenzyl and R 23  is 3-formaldoximebenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 4-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclobutylmethyl and R 23  is cyclobutylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopentylmethyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3n-butyl  n- butyl  and R 23  is CH 2 CH═C(CH 3 ) 2 ;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is H;  
       the compound of formula (IIa) wherein R 22  is 3-fluorobenzyl and R 23  is 3-fluorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-methoxybenzyl and R 23  is 3-methoxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3,4-difluorobenzyl and R 23  is 3,4-difluorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-methylbenzyl and R 23  is 4-methylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-chlorobenzyl and R 23  is 4-chlorobenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 4-fluorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-chlorobenzyl and R 23  is 3-chlorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-nitrobenzyl and R 23  is 3-nitrobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-methylbenzyl and R 23  is 3-methylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-bromobenzyl and R 23  is 3-bromobenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-fluorobenzyl and R 23  is H;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-chlorobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 3-aminobenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-aminobenzyl and R 23  is 4-aminobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-nitrobenzyl and R 23  is H;  
       the compound of formula (IIa) wherein R 22  is 3-(NHCHO)benzyl and R 23  is 3-(NHCHO)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(NHCOCH 3 )benzyl and R 23  is 3-(NHCOCH 3 )benzyl;  
       the compound of formula (IIa) wherein R 22  is 3,4-dihydroxybenzyl and R 23  is 3,4-dihydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-formaldoximebenzyl and R 23  is 3-(N-hydroxy)aminomethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-hydroxy)aminomethylbenzyl and R 23  is 3-(N-hydroxy)aminomethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 OC(═O)O-)benzyl and R 23  is 3-(CH 3 OC(═O)O-)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1-hydroxyethyl)benzyl and R 23  is 3-(1-hydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HOCH 2 CH 2 N═CH)benzyl and R 23  is 3-(HOCH 2 CH 2 N═CH)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HOCH 2 CH 2 N═CH)benzyl and R 23  is 3-(2-oxazolidinyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(C 6 H 5 CH 2 NHC(═O)O)benzyl and R 23  is 3-(C 6 H 5 CH 2 NHC(═O)O)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 NHC(═O)O)benzyl and R 23  is 3-(CH 3 NHC(═O)O)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HOCH 2 CC)benzyl and R 23  is 3-bromobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-acetylbenzyl and R 23  is 3-bromobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-acetylbenzyl and R 23  is 3-acetylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 C(═NOH))benzyl and R 23  is 3-(CH 3 C(═NOH))benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1-hydroxyethyl)benzyl and R 23  is 3-bromobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(chloromethyl)benzyl and R 23  is 3-(chloromethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(5-tetrazolyl)benzyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-cyanobenzyl and R 23  is 3-formylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-acetoxybenzyl and R 23  is 4-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminocarbonylbenzyl and R 23  is 3-aminocarbonylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NCOCH 2 O)benzyl and R 23  is 3-(H 2 NCOCH 2 O)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxybenzyl and R 23  is H;  
       the compound of formula (IIa) wherein R 22  is 3-methylbenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 2-naphthylmethyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NNHC(═O))-benzyl and R 23  is 3-(H 2 NNHC(═O))-benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-(H 2 NNHC(═O))-benzyl and R 23  is 4-(H 2 NNHC(═O))-benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═O)NHN═CH)-benzyl and R 23  is 3-(H 2 NC(═O)NHN═CH)-benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-[(N-methoxy)aminocarbonyl]-benzyl and R 23  is 3-[(N-methoxy)aminocarbonyl]-benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-[(N-methoxy)aminocarbonyl]-benzyl and R 23  is 4-[(N-methoxy)aminocarbonyl]-benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HOCH 2 CH(OH)CH 2 O)benzyl and R 23  is 3-(HOCH 2 CH(OH)CH 2 O)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2-hydroxyethoxy)benzyl and R 23  is 3-(2-hydroxyethoxy)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1,2-dihydroxyethyl)benzyl and R 23  is 4-(1,2-dihydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminocarbonylbenzyl and R 23  is 3-(H 2 NC(═NH))benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxybenzyl and R 23  is 3-formyl-4-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-(N-methylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-methylaminocarbonyl)benzyl and R 23  is 3-(N-methylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 2-naphthylmethyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1,2-dihydroxyethyl)benzyl and R 23  is 3-(1,2-dihydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-(1,2-dihydroxyethyl)benzyl and R 23  is 4-(1,2-dihydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-(N-methylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is hydrogen;  
       the compound of formula (IIa) wherein R 22  is 3-(boronic acid)benzyl and R 23  is 3-(boronic acid)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-nitrobenzyl and R 23  is 3-benzyloxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-ethylaminocarbonyl)benzyl and R 23  is 3-(N-ethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-(N,N-diethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-(N-ethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 6-hydroxy-1-hexyl and R 23  is hydrogen;  
       the compound of formula (IIa) wherein R 22  is 6-hydroxy-1-hexyl and R 23  is 6-hydroxy-1-hexyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 6-hydroxy-1-hexyl;  
       the compound of formula (IIa) wherein R 22  is 5-carboxy-1-pentyl and R 23  is 5-carboxy-1-pentyl;  
       the compound of formula (IIa) wherein R 22  is 3-iodobenzyl and R 23  is 3-iodobenzyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is 2-(hydroxymethyl)-cyclopropylmethyl,  
       the compound of formula (IIa) wherein R 22  is 3-(thiomethyl)benzyl and R 23  is 3-(thiomethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(methylsulfonyl)benzyl and R 23  is 3-(methylsulfonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 6-hexenyl and R 23  is 6-hexenyl;  
       the compound of formula (IIa) wherein R 22  is 6-bromo-5-hydroxy-1-hexyl and R 23  is 6-bromo-5-hydroxy-1-hexyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 5-hydroxy-1-pentyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═O)NH)benzyl and R 23  is 3-(H 2 NC(═O)NH)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-methylamino)benzyl and R 23  is 3-(N-methylamino)benzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-aminobenzyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-nitrobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N,N-dimethylamino)benzyl and R 23  is 3-(N,N-dimethylamino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-nitrobenzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 3-(CH 3 NHC(═O)NH)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 NHC(═O)NH)benzyl and R 23  is 3-(CH 3 NHC(═O)NH)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-methylamino)benzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N,N-dimethylaminoglycyl)amino)benzyl and R 23  is 3-((N,N-dimethylaminoglycyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N-methylaminoglycyl)amino)benzyl and R 23  is I-((N-methylaminoglycyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N,N-dimethylaminoglycyl)amino)benzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N-phenylmethoxycarbonylaminoglycyl)amino)benzyl and R 23  is 3-(N-phenylmethoxycarbonylaminoglycyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(glycylamino)benzyl and R 23  is 3-(glycylamino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(glycylamino)benzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N-phenylmethoxycarbonylamino-L-alanyl)amino)benzyl and R 23  is 3-((N-phenylmethoxycarbonylamino-L-alanyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-((N-phenylmethoxycarbonylamino-L-phenylalanyl)amino)benzyl and R 23  is 3-((N-phenylmethoxycarbonylamino-L-phenylalanyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(L-alanyl)amino)benzyl and R 23  is 3-(L-alanyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(L-phenylalanyl)amino)benzyl and R 23  is 3-(L-phenylalanyl)amino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is hydrogen;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 6-hydroxy-1-hexyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is (5-methylsulfonyl)-1-pentyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 5-(CH 3 S(O))-1-pentyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 5-methoxy-1-pentyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 3-cyanobenzyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 3-carboethoxybenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxy-1-hexyl and R 23  is 4-hydroxy-1-hexyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxy-1-hexyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 4-oxime-1-hexyl and R 23  is 4-oxime-1-hexyl;  
       the compound of formula (IIa) wherein R 22  is 5-hydroxy-1-pentyl and R 23  is 3-hydroxyrethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 6-amino-1-hexyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N,N-diethylaminocarbonyl)benzyl and R 23  is 3-(N,N-diethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-(N,N-diethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-carbomethoxybenzyl and R 23  is 3-(N-ethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is hydrogen;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-(N,N-diethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-(N-ethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-propylaminocarbonyl)benzyl and R 23  is 3-(N-propylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HO 2 C)benzyl and R 23  is 3-(N-isopropylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HO 2 C)benzyl and R 23  is 3-(N-propylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HO 2 C)benzyl and R 23  is benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(HO 2 C)benzyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is 3-(HO 2 C)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-pyridinylmethyl;  
       the compound of formula (IIa) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is 3-aminocarbonylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-aminocarbonylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminocarbonylbenzyl and R 23  is hydrogen;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-(N-ethylaminocarbonyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-(N-methylamino)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-methylamino)benzyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IIa) wherein R 22  is 4-formylbenzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1-hydroxy-1-ethyl)benzyl and R 23  is 3-(1-hydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-pyridinylmethyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(N-imidazolylmethyl)benzyl and R 23  is 3-(N-imidazolylmethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2,2-dimethyl-1-propionyl)benzyl and R 23  is 3-(2,2-dimethyl-1-propionyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2,2,2-trifluoro-1-hydroxyethyl)benzyl and R 23  is 3-(2,2,2-trifluoro-1-hydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2-imidazolyl-C(═O))benzyl and R 23  is 3-(2-imidazolyl-C(═O))benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(3-hydroxy-1-propyn-1-yl)benzyl and R 23  is 3-(3-hydroxy-1-propyn-1-yl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2,2,2-trifluoroacetyl)benzyl and R 23  is 3-(2,2,2-trifluoroacetyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-propionylbenzyl and R 23  is 3-propionylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(4-pyrazolyl)benzyl and R 23  is 3-(4-pyrazolyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 CH 2 C(═NOH))benzyl and R 23  is 3-(CH 3 CH 2 C(═N—OH))benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-sulfonamidobenzyl and R 23  is 3-sulfonamidobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CF 3 CH 2 C(═NOH))benzyl and R 23  is 3-(CF 3 CH 2 C(═N—OH))benzyl;  
       the compound of formula (IIa) wherein R 22  is 4-fluoromethylbenzyl and R 23  is 4-fluoromethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 4-(1-hydroxyethyl)benzyl and R 23  is 4-(1-hydroxyethyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(5-methyl-1,2,3-oxadiazolyl)benzyl and R 23  is 3-(5-methyl-1,2,3-oxadiazolyl)benzyl;  
       the compound of formula (IIa) wherein R 22  3-(H 2 NC(═NOH)benzyl   3 -( H   2   NC ( ═NOH )) benzyl  and R 23  is 3-(H 2 NC(═NOH)benzyl   3 -( H   2   NC ( ═NOH )) benzyl;    
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═NOH)-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl  and R 23  is 3-(H 2 NC(═NOH)-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl;    
       the compound of formula (IIa) wherein R 22  is 5-benzotriazolylmethyl and R 23  is 5-benzotriazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-benzimidazolylmethyl and R 23  is 5-benzimidazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-benzimidazolylmethyl and R 23  is 5-benzimidazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-benzotriazolylmethyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IIa) wherein R 22  is 5-benzotriazolylmethyl and R 23  is 3-(3-pyrazolyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 5-indazolylmethyl and R 23  is 5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-chloro-5-indazolylmethyl and R 23  is 3-chloro-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methylamino-5-indazolylmethyl and R 23  is 3-methylamino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-ethylamino-5-indazolylmethyl and R 23  is 3-ethylamino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 6-indazolylmethyl and R 23  is 6-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-amino-5-benzisoxazolylmethyl and R 23  is 3-amino-5-benzisoxazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-(2-aminobenzoxazolyl   5 -(   2   - amino ) benzoxazolyl  and R 23  is 5-(2-aminobenzoxazolyl   5 -(   2   - amino ) benzoxazolyl.    
     
     
       10. A compound of  claim 1  of formula (IIaa):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 4  and R 7  are independently selected from: benzyl, methylbenzyl, dimethylbenzyl, ethylbenzyl, fluorobenzyl, pyrrolylmethyl, methoxybenzyl, isobutyl, nitrobenzyl, aminobenzyl, hydroxybenzyl, thienylmethyl, pyridylmethyl, or naphthylmethyl;  
       R 22  and R 23  are independently selected from:  
       hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C(CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamantyl ethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH)-benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hyroxylaminomethylbenzyl  N- hydroxylaminomethylbenzyl , (hydroxyl)ethylbenzyl, (CH 3 C(═NOH))-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHN═CH)-benzyl, (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)benzyl, hydroxyethoxybenzyl(oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethylbenzyl, N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxylpentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, (CH 3 NHC(═O)O)benzyl, (NH 2 C(═O)CH 2 O)benzyl, (NH 2 C(═NH))benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbepzyl  imidazolylbenzyl, aminoimidazolylbenzyl.  
     
     
       11. A compound of  claim 10  of formula (IIaa):                    
       or a pharmaceutically acceptable salt form thereof, selected from the group consisting of: 
       the compound of formula (IIaa) wherein R 4  and R 7  are isobutyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are isobutyl, R 22  and R 23  are allyl;  
       the compound of formula (IIaa) wherein R 4  is 4-nitrobenzyl, R 7  is 2-nitrobenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-nitrobenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  is 4-nitrobenzyl, R 7  is 2-nitrobenzyl, R 22  and R 23  are n-butyl;  
       the compound of formula (IIaa) wherein R 4  is 4-aminobenzyl, R 7  is 2-aminobenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-hydroxybenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 4-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-aminocarbonylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-acetylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-butyrylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-(CH 3 C(═N—OH)benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-methoxybenzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-(H 2 NC(═NOH)benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-fluorobenzyl, R 22  and R 23  are 3-(H 2 NC(═NOH)-4-fluorobenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-methoxybenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-methoxybenzyl, R 22  and R 23  are 4-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-methoxybenzyl, R 22  and R 23  are 3-methoxybenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-hydroxybenzyl, R 22  and R 23  are 3-hydroxybenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methoxybenzyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methoxybenzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methoxybenzyl, R 22  and R 23  are 2-naphthylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methoxybenzyl, R 22  and R 23  are 4-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-hydroxybenzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methoxybenzyl, R 22  and R 23  are allyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-(2-hydroxyethoxy)benzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-(2-morpholinylethoxy)benzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3-(H 2 NC(═O)CH 2 0)benzyl, R 22  and R 23  are n-butyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3,4-difluorobenzyl, R 22  and R 23  are 3-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3,4-difluorobenzyl, R 22  and R 23  are 4-hydroxymethylbenzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3,4-difluorobenzyl, R 22  and R 23  are 3-(H 2 NC(═O))benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 3,4-difluorobenzyl, R 22  and R 23  are 3-(H 2 NC(═NOH))benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 2-naphthylmethyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 2-naphthylmethyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 2-thienylmethyl, R 22  and R 23  are cyclopropylmethyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 2-thienylmethyl, R 22  and R 23  are 3-(H 2 NC(═NOH))benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-methylthiobenzyl, R 22  and R 23  are benzyl;  
       the compound of formula (IIaa) wherein R 4  and R 7  are isopropyl, R 22  and R 23  are n-hexyl;  and  
       the compound of formula (IIaa) wherein R 4  and R 7  are 4-pyridylmethyl, R 22  and R 23  are benzyl.  
     
     
       12. A compound of  claim 1  of formula (IIb):                    
       or a pharmaceutically acceptable salt form thereof wherein 
       R 22  and R 23  are independently selected from the group consisting of:  
       hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C(CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, mnethoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH)-benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (CH 3 C(═NOH))-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHN═CH)-benzyl, (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)-benzyl, hydroxyethoxybenzyl(oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethylbenzyl, N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl)phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropyrnyl)benzyl, (imidazolyl—C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxypentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N, N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, (CH 3 NHC(═O)O)benzyl, (NH 2 C(═O)CH 2 0)benzyl, (NH 2 C(═NH))benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbenzyl, aminoimidazolylbenzyl.  
     
     
       13. A compound of  claim 12  of formula (IIb):                    
       or a pharmaceutically acceptable salt form thereof, selected from the group consisting of: 
       the compound of formula (IIb) wherein R 22  is 4hydroxybenzyl and R 23  is 4hydroxybenzyl;  
       the compound of formula (IIb) wherein R 22  is cyclopentylmethyl and R 23  is cyclopentylmethyl;  
       the compound of formula (IIb) wherein R 22  is n-butyl and R 23  is n-butyl;  
       the compound of formula (IIb) wherein R 22  is 3-hydroxybenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IIb) wherein R 22  is 3-aminobenzyl and R 23  is 3-aminobenzyl;  
       the compound of formula (IIb) wherein R 22  is cyclohexylmethyl and R 23  is cyclohexylmethyl;  
       the compound of formula (IIb) wherein R 22  is cyclobutylmethyl and R 23  is cyclobutylmethyl;  
       the compound of formula (IIb) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-hydroxymethylbenzyl;  
       the compound of formula (IIb) wherein R 22  is 3-formylbenzyl and R 23  is 3-formylbenzyl;  
       the compound of formula (IIb) wherein R 22  is 3-formaldoximebenzyl and R 23  is 3-formaldoximebenzyl.  
     
     
       14. A compound of  claim 1  of the formula (Ibb):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 22  and R 23  are independently selected from the group consisting of:  
       hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C (CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamantylmethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═))-benzyl  ( H   2   NC ( ═O ))- benzyl,  carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH)-benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (CH 3 C(═NOH))-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHH═CH)-benzyl  ( H   2   NC ( ═O ) NHN═CH )- benzyl , (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)-benzyl, hydroxyethoxybenzyl(oxazolindinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethylbenzyl, N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl—C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxypentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, (CH 3 NHC(═O)O)benzyl, (NH 2 C(═O)CH 2 O)benzyl, (NH 2 C(═NH))-benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbenzyl, aminoimidazolylbenzyl.  
     
     
       15. A compound of  claim 14  of formula (Ibb):                    
       or a pharmaceutically salt form thereof, selected from the group consisting of: 
       the compound of formula (Ibb) wherein R 22  is benzyl and R 23  is hydrogen;  
       the compound of formula (Ibb) wherein R 22  is cyclopropylmethyl and R 23  is cyclopropylmethyl;  
       the compound of formula (Ibb) wherein R 22  is benzyl and R 23  is benzyl;  
       the compound of formula (Ibb) wherein R 22  is 3-hydroxybenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (Ibb) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-hydroxymethylbenzyl;  
       the compound of formula (Ibb) wherein R 22  is 4-hydroxybenzyl and R 23  is 4-hydroxybenzyl;  
       the compound of formula (Ibb) wherein R 22  is 3-methoxybenzyl and R 23  is 3-methoxybenzyl;  
       the compound of formula (Ibb) wherein R 22  is 3-(H2NC(═NOH))benzyl   3 -( H   2   NC ( ═NOH )) benzyl  and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (Ibb) wherein R 22  is 3-(H2NC(═NOH))benzyl   3 -( H   2   NC ( ═NOH )) benzyl  and R 23  3-(H2NC(═NOH))benzyl   3 -( H   2   NC ( ═NOH )) benzyl ; and 
       the compound of formula (Ibb) wherein R 22  is 3-(H2NC(═NOH))-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl  and R 23  is 3-(H2NC(═NOH))-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl.    
     
     
       16. A compound of  claim 1  of formula (IId):                    
       or a pharmaceutically acceptable salt form thereof wherein: 
       R 22  and R 23  are independently selected from the group consisting of:  
       hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, CH 2 CH═C(CH 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyloxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl,  vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl,  benzyloxybenzyl, phenylbenzyl, adamanmylethyl  adamantylethyl, cyclopropyline thoxybenzyl  cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and  dimethylallyl, aminomethylbenzyl, (O-benzyl-formaldoxime)benzyl, (O-methyl-formaldoxime)benzyl, (CH 3 O 2 CO)-benzyl, (HOCH 2 CH 2 N═CH)-benzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, N-hydroxylaminobenzyl, phenylmethyl-boronic acid, N-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (CH 3 C(═NOH))-benzyl, (H 2 NNHC(═O))-benzyl, (H 2 NC(═O)NHN═CH)-benzyl, (CH 3 ONHC(═O))-benzyl, (HONHC(═O))-benzyl, (CH 3 NHC(═O))-benzyl, N,N-dimethylaminocarbonylbenzyl, (HOCH 2 CH(OH)CH 2 O)-benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, N,N-dimethylaminomethlbenzyl  N,N- dimethylaminomethylbenzyl,  N-methylaminomethylbenzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (N-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (N-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl, N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N,N-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (H 2 NSO 2 )-benzyl, dihydroxyethylbenzyl, (MeHNC(═O)NH)-benzyl, (H 2 NC(═O)NH)-benzyl, (HC(═O)NH)-benzyl, methanesulfonylpentyl, methoxypentyl, N-formyl-N-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (CH 3 CH 2 C(═NOH))-benzyl, (trifluorohydroxyethyl)benzyl, (CF 3 C(═NOH))-benzyl, (N-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-NHC(═O)O)benzyl, (CHBNHC(═O)O)benzyl  ( CH   3   NHC ( ═O ) O ) benzyl , (NH 2 C(═O)CH 2 O)benzyl, (NH 2 C(═NH))benzyl, ((N-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((CH 3 ) 3 C—C(═O))benzyl, (N-methyl-N-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, furylmethyl, 3-aminoindazolylmethyl, 3-aminobenzoxazolylmethyl, aminopyrazolylbenzyl, imidazolylbenzyl, aminoimidazolylbenzyl.  
     
     
       17. A compound of  claim 16  of formula (IId):                    
       or a pharmaceutically acceptable salt form thereof, selected from the group consisting of: 
       the compound of formula (IId) wherein R 22  is 4-hydroxymethylbenzyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IId) wherein R 22  is 3-hydroxybenzyl and R 23  is 3-hydroxybenzyl;  
       the compound of formula (IId) wherein R 22  is cyclopropylmethyl and R 23  is cyclopropylmethyl;  
       the compound of formula (IId) wherein R 22  is 2-naphthylmethyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (lid) wherein R 22  is 4-hydroxybenzyl and R 23  is 4-hydroxybenzyl;  
       the compound of formula (IId) wherein R 22  is 3-aminobenzyl and R 23  is 3-aminobenzyl;  
       the compound of formula (IId) wherein R 22  is 3-hydroxymethylbenzyl and R 23  is 3-hydroxymethylbenzyl;  
       the compound of formula (IId) wherein R 22  is 3-(Me 2 NCH 2 C(═O)NH)-benzyl and R 23  is 3-(Me 2 NCH 2 C(═O)NH)benzyl;  
       the compound of formula (IId) wherein R 22  is 3-formaldoximebenzyl and R 23  is 3-formaldoximebenzyl;  
       the compound of formula (IId) wherein R 22  is 3-(CH 3 C(═N—OH))-benzyl and R 23  is 3-(CH 3 C═N—OH))-benzyl   3 -( CH   3   C ( ═N—OH ))- benzyl;    
       the compound of formula (IId) wherein R 22  is 3-(2-amino-4-thienyl)benzyl and R 23  is 3-(2-amino-4-thienyl)benzyl;  
       the compound of formula (IId) wherein R 22  is 5-hydroxypentyl and R 23  is 5-hydroxypentyl;  
       the compound of formula (IId) wherein R 22  is 6-hydroxypentyl and R 23  is 6-hydroxypentyl;  
       the compound of formula (IId) wherein R 22  is 5-hydroxypentyl and R 23  is 2-naphthylmethyl;  
       the compound of formula (IId) wherein R 22  is 5-hydroxypentyl and R 23  is 4-hydroxymethylbenzyl;  
       the compound of formula (IId) wherein R 22  is 5-hydroxypentyl and R 23  is 3-hydroxymethylbenzyl.  
     
     
       18. A compound of  claim 1  of formula (IIa):                    
       or a pharmaceutically acceptable salt form thereof, wherein: 
       R 22  is selected from:  
       cyclopropylmethyl, n-butyl, allyl, benzyl, naphthylmethyl, carboxybenzyl, methoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, (1-hydroxy-2-propyl)benzyl, aminobenzyl, formylbenzyl, cyanobenzyl, 3-methylbutyl, 2-methylpropyl, n-pentyl, 3-N-N-dimethylaminobenzyl, 3,4-methylenedioxybenzyl, pyridinylmethyl, pyridinylethyl, fluorobenzyl, difluorobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (H 2 NC(═O))-benzyl, carbomethoxybenzyl, N,N-dimethylaminobenzyl, carboethoxybenzyl, N-benzylaminocarbonylbenzyl, N-methylaminobenzyl, N-ethylaminobenzyl, N-propylaminobenzyl, N-butylaminobenzyl, acetylbenzyl, (CH 3 C(═NOH))-benzyl, N-methylaminocarbonylbenzyl, N,N-diethylaminocarbonylbenzyl, N,N-dimethylaminocarbonylbenzyl, (hydroxyl)hexyl, (hydroxyl)pentyl, (methylthio)benzyl, glycylaminobenzyl, N,N-dimethylglycylaminobenzyl, alanylaminobenzyl, (CH 3 CH 2 NHC(═O))-benzyl, N,N-diethylaminocarbonylbenzyl,  N-ethylaminocarbonylbenzyl, N-propylaminocarbonylbenzyl, N,N-diisopropylaminocarbonylbenzyl, N, N-di-n-propylaminocarbonylbenzyl, (imidazolyl-C(═O))-benzyl, (pyrazolyl-C(═O))-benzyl, 3-phenylalanylaminobenzyl, 3-(N-methylglycyl)aminobenzyl, 3-(CH 3 C(═NOH))benzyl, 2-amino-5-benzoxazolylmethyl, 3-amino-5-benzisoxazolylmethyl, 3-methylamino-5-indazolylmethyl, 3-ethylamino-5-indazolylmethyl, 3,4-dihydroxybenzyl, (pyridylmethylaminocarbonyl)benzyl, (oxadiazolidinonyl)benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, acetylaminobenzyl, (CH 3 CH 2 C(═NOH))benzyl, (CF 3 C(═NOH))-benzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (N,N-dimethylaminoethyl)aminocarbonylbenzyl, (N,N-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (NH 2 C(═NH))benzyl, (imidazolylmethyl)benzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, thienylmethyl, thiazolylmethyl, thiazolylethyl, furylmethyl, 3-aminoindazolylmethyl, 3-chloroindazolylmethyl, 3-methylaminoindazolylmethyl, 3-ethylaminoindazolylmethyl, 3-methoxyindazolylmethyl, 3-methylindazolylmethyl, 3-ethylindazolylmethyl, 3-methoxycarbonylindazolylmethyl; and  
       R 23 R   23  is selected from:  
       naphthylmethyl, hydroxymethylbenzyl, (1-hydroxy-2-propyl)benzyl, aminobenzyl, acetylbenzyl, (CH 3 C(═NOH))-benzyl, (pyrazolyl)benzyl, (CH 3 CH 2 C(═NOH))-benzyl, (CF 3 C(═NOH))-benzyl, (H 2 NC(═NOH))benzyl, (H 2 NC(═NOH))fluorobenzyl, benzimidazolylmethyl, benzotriazolylmethyl, indazolylmethyl, benzoxazolinylmethyl, benzisoxazolylmethyl, 3-aminoindazolylmethyl, 3-chloroindazolylmethyl, 3-methylaminoindazolylmethyl, 3-ethylaminoindazolylmethyl, 3-methoxyindazolylmethyl, 3-methylindazolylmethyl, 3-ethylindazolylmethyl, or 3-methoxycarbonylindazolylmethyl.  
     
     
       19. A compound of  claim 1  of formula (IIa):                    
       or a pharmaceutically acceptable salt form thereof, selected from the group consisting of: 
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 3-aminobenzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(CH 3 C(═NOH))benzyl and R 23  is 3-(CH 3 C(═NOH))benzyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═NOH)-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl  and R 23  is 3-(H 2 NC(═NOH)-4-fluorobenzyl   3 -( H   2   NC ( ═NOH ))-   4   - fluorobenzyl;    
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═NOH)benzyl   3 -( H   2   NC ( ═NOH )) benzyl  and R 23  is 3-(H 2 NC(═NOH)benzyl   3 -( H   2   NC ( ═NOH )) benzyl;    
       the compound of formula (IIa) wherein R 22  is 3-(3-pyrazolyl)benzyl and R 23  is 3-(3-pyrazolyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is 5-indazolylmethyl and R 23  is 5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-chloro-5-indazolylmethyl and R 23  is 3-chloro-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methylamino-5-indazolylmethyl and R 23  is 3-methylamino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-ethylamino-5-indazolylmethyl and R 23  is 3-ethylamino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 6-indazolylmethyl and R 23  is 6-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-amino-5-indazolylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methoxycarbonyl-5-indazolylmethyl and R 23  is 3-methoxycarbonyl-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-cyclopropylmethylaminobenzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(1-hydroxy-2-propyl)benzyl and R 23  is 3-(1-hydroxy-2-propyl)benzyl;  
       the compound of formula (IIa) wherein R 22  is n-butyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(n-propylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-[C 3 H 7 C(═NOH)]benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 5-indazolylymethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(H 2 NC(═NOH)-4-fluorobenzyl and R 23  is 5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 2-naphthylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-aminobenzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(n-butylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(ethylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(dimethylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(2-phenylethylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is cyclopropylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-thienylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methoxy-5-indazolylmethyl and R 23  is 3-methoxy-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-chloro-5-indazolylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methyl-5-indazolylmethyl and R 23  is 3-methyl-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-ethyl-5-indazolylmethyl and R 23  is 3-ethyl-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-n-butyl-5-indazolylmethyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-methyoxybenzyl and R 23  is 3-amino-5-indazolylmethyl;  
       the compound of formula (IIa) wherein R 22  is 3-(isopropylamino)benzyl and R 23  is 3-amino-5-indazolylmethyl .  
     
     
       20. A compound of  claim 1 , or a pharmaceutically acceptable salt form thereof, selected from the following formulae:                    
       wherein 
       R 4  and R 7  are independently selected from the following groups:  
       hydrogen;  
       C 1 -C 3  alkyl substituted with 0-R 11   0 - 3  R 11 ;  
       R 5  is —OR 20 ;  
       R 6  is hydrogen or —OR 21 ;  
       R 20  and R 21  are H;  
       R 11  is selected from one or more of the following:  
       H; halogen; —OR 13 ;  
       C 3 -C 10  cycloalkyl substituted with 0-2 R 12 ;  
       C 1 -C 4  alkyl substituted with 0-2 R 12 ;  
       aryl(C 1 -C 3  alkyl) substituted with 0-2 R 12 ;  
       aryl substituted with 0-2 R 12 ; or  
       a heterocyclic ring system selected from pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, oxazolidinyl, said heterocyclic ring system being substituted with 0-2 R 12 ;  
       R 12 , when a substituent on carbon, is selected from one or more of the following:  
       benzyloxy, halogen, methyl, C 1 -C 4  alkoxy, CF 3 , 2-(1-morpholino)ethoxy, —CO 2 H, hydroxamic acid, hydrazide, —C(R 14 )═N(OR 14 ), cyano, boronic acid, sulfonamide, formyl, C 3 -C 6  cycloalkoxy, C 1 -C 4  alkyl substituted with —NR 13 R 14 , —NR 13 R 14 , hydroxy, hydroxymethyl; or  
       R 12 , when a substituent on nitrogen, is methyl;  
       R 13  is H, C 1 -C 4  alkyl, C 2 -C 4  alkenyl, or benzyl;  
       R 14  is OH, H, CF 3 , C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , C 2 -C 4  alkenyl, or benzyl;  
       R 13  and R 14  can alternatively join to form —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH 2 CH 2 N(R 15 )CH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —;  
       R 15  is H or CH 3 ;  
       R 22  and R 23  are independently selected from the following:  
       hydrogen;  
       C 1 -C 8  alkyl substituted with 0-3 R 31 ;  
       C 2 -C 6  alkenyl substituted with 0-3 R 31 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 31 ;  
       R 31  is selected from one or more of the following:  
       halogen, —OR 13 , C 1 -C 4  alkyl, C 3 -C 10  cycloalkyl, —C(R 14 )═N(OR 14 ), —CO 2 R 13 , —S(O) m R 13 ;  
       aryl substituted with 0-5 R 32 ; or  
       a heterocyclic ring system chosen from pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, oxazolidinyl, said heterocyclic ring being substituted with 0-2 R 32 ;  
       R 32 , when a substituent on carbon, is selected from one or more of the following:  
       benzyloxy, halogen, 2-(1-morpholino)ethoxy, —CO 2 R 13 , hydroxamic acid, —CONR 13 NR 13 R 14 , cyano, boronic acid, sulfonamide, —CHO, C 3 -C 6  cycloalkoxy, —NR 13 R 14 , —C(R 14 )═N(OR 14 ), NO 2 , —OR 13 , —NR 40 R 41 , —SO m R 13 , —SO m NR 13 R 14 , —C(═O)NR 13 R 14 , —OC(═O)NR 13 R 14 , —C(═O)R 11 , —OC(═O)R 11 , —OCO 2 R 13 , phenyl, —C(═O)NR 13 -(C 1 -C 4  alkyl)—NR 13 R 14 , —C(═O)NR 40 R 41 , C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, C 2 -C 4  haloalkenyl, C 1 -C 4  haloalkynyl  C 2   -C   4    haloalkynyl ,  
       —C(═O)NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       C 1 -C 4  alkoxy substituted with 0-3 groups selected from:  
       R 11 , C 3 -C 6  cycloalkyl, —C(═O)NR 13 R 14 , —NR 13 R 14 or OH ;  
       C 1 -C 4  alkyl substituted with 0-3 groups selected from:  
       R 11 , ═NR 14 , ═NNR 13 C(═O)NR 13 R 14  or —NR 13 R 14 ;  
       C 2 -C 4  alkenyl substituted with 0-3 R 11 ;  
       C 2 -C 4  alkynyl substituted with 0-3 R 11 ;  
       a 5- or 6-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen or sulfur substiuted with 0-2 R 12 ;  
       R 32  when a substituent on nitrogen is methyl;  
       m is 0, 1, or 2;  
       R 40  is selected from: H, C 1 -C 3  alkyl;  
       R 41  is selected from:  
       —C(═O)NR 13 R 14 ;  
       —C(═O)NR 13 NR 14 —C( ═O ) NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 R 14 ;  
       —C(═O)C(R 11 ) 2 NR 13 NR 14 —C( ═O ) C ( R   11 ) 2   NR   13   NR   13   R   14 ;  
       —C(═O)C(R 11 ) 2 NR 13 CO 2 R 13 ;  
       —C(═O)H;  
       —C(═O)R 11 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 R 14 ;  
       —C(═O)—(C 1 -C 4  alkyl)-NR 13 CO 2 R 13 ; or  
       1-3 amino acids linked together via amide bonds, and linked to the N atom via the carboxylate terminus.  
     
     
       21. A compound of formula ( IIa ) :                      
         or a pharmaceutically acceptable salt form thereof, wherein R   22    is  3   - aminobenzyl and R   23    is  3   - aminobenzyl.