5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

Abstract

The Compound of Formula I and pharmaceutically acceptable sales thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.

What is claimed is:  
     
       1. A compound of the formula I                    
       or a pharmaceutically acceptable salt thereof. 
     
     
       2. A method of selectively inhibiting cyclooxygenase-2 comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to  claim 1 . 
     
     
       3. A method of treating a cyclooxygenase-2 mediated disease in patients having a history of a gastro-intestinal disorder comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to  claim 1 . 
     
     
       4. A method of selectively inhibiting cyclooxygenase-2 comprising administration to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound according to  claim 1 . 
     
     
       5. A method for selectively inhibiting cyclooxygenase-   2     activity in a human host, comprising administering a non - steroidal compound that selectively inhibits activity of the cyclooxygenase -   2  gene product to a human host in need of such treatment, wherein said non - steroidal compound is a compound of the formula I                     
       
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       6. The method of  claim 5 , wherein the compound of formula I is administered at a dosage of from about  0 . 01  mg to about  140  mg per kilogram of body weight per day. 
     
     
       7. The method of  claim 5 , wherein the compound of formula I is administered in an amount from about  1  mg to about  1000  mg.