USRE38435EExpiredUtilityPatentIndex 63

Separating agent

Assignee: DAICEL CHEMPriority: Dec 28, 1983Filed: Sep 22, 1997Granted: Feb 24, 2004

Est. expiryDec 28, 2003(expired)· nominal 20-yr term from priority

Inventors:OKAMOTO YOSHIO HATADA KOICHI SHIBATA TOHRU OKAMOTO ICHIRO NAKAMURA HIROYUKI

C07C 45/78B01D 15/3833B01J 20/3219C07B 57/00B01J 20/3295B01J 20/3274B01J 20/22B01J 20/3282B01J 20/321B01J 20/3204C07B 63/00

PatentIndex Score

Cited by

References

Claims

Abstract

A mixture of chemical substances such as optical isomers, geometrical isomers and polymers having different molecular weight ranges is separated to each ingredient by use of a cellulose derivative having an aromatic ring in the chromatographic method.

Claims

exact text as granted — not AI-modified

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A separating agent which comprises a cellulose derivative selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl, said cellulose derivative being supported on a porous carrier having a particle size of from 1 micron to 10 millimeters and a pore size of from 10 Angstrom units to 100 microns.

2. A separating agent as claimed in claim 1 in which said cellulose derivative is cellulose tribenzoate.

3. A separating agent as claimed in claim 1 , wherein the amount of said cellulose derivative supported on said carrier is from 1-100 wt.% based on the weight of the carrier.

4. A separating agent as claimed in claim 1 , wherein the ratio of pore size to particle size of said carrier is not larger than 0.1:1.

5. A separating agent as claimed in claim 1 , wherein said carrier is an inorganic substance selected from the group consisting of silica, alumina, magnesia, titanium oxide, glass, silicate and kaolin.

6. A separating agent as claimed in claim 1 , wherein said carrier is an organic substance selected from the group consisting of polystyrene, polyacrylamide and polyacrylate.

7. A separating agent as claimed in claim 1 in which said cellulose derivative is coated on said carrier and has been prepared by mixing said carrier with a solution of said cellulose derivative in a solvent therefor, and then removing said solvent.

8. A separating agent as claimed in claim 1 , in which said carrier is an inorganic substance.

9. A separating agent as claimed in claim 8 , in which said inorganic substance is silica gel.

10. A chromatographic isomer separating agent comprising a derivative of cellulose selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl having a number average degree of polymerization in the range of 5-5000 supported on a solid carrier having a particle size of from 1 micron to 10 millimeters.

11. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tribenzoate.

12. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(3-chlorobenzoate).

13. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(3,5-dichlorobenzoate).

14. A chromagraphic isomer separating agent as claimed in claim 10 in which said cellulose derivative is cellulose tris(4-chlorobenzoate).

15. A chromatographic isomer separating agent as claimed in claim 10 , wherein said cellulose derivative is immobilized on solid carrier particles, wherein said carrier particles are from 1 μm-10 mm in diameter and the amount of said cellulose derivative supported is from 1-100 wt.% based on the weight of the carrier particles.

16. A chromatographic isomer separating agent as claimed in claim 15 wherein said carrier particles are porous and have pore diameters of from 10 Å-100 μm.

17. A chromatographic isomer separating agent as claimed in claim 16 , wherein said carrier particles have an approximate pore size to particle size ratio of no greater than 0.1:1.

18. A chromatographic isomer separating agent as claimed in claim 15 , wherein said carrier is an inorganic substance selected from among silica, alumina, magnesia, titanium oxide, glass, silicate and kaolin.

19. A chromatographic isomer separating agent as claimed in claim 15 , wherein said carrier is silica gel.

20. A chromatographic isomer separating agent as claimed in claim 15 , wherein said carrier is an organic substance selected from the group consisting of polystyrene, polyacrylamide and polyacrylate.

21. In a chromatographic column used in the chiral separation of a chemical substance from a mixture containing the same, the improvement comprising said column containing a porous carrier having a pore size of 50 to 50 , 000 Å and supported thereon a cellulose derivative separating agent consisting of cellulose having a ring- substituted or unsubstituted phenyl group attached thereto through a urethane group, the separating agent being in a dissolved state during the supporting thereof on the carrier.

22. The column of claim 21 , wherein said carrier has a particle size of about 1 μm to about 10 mm.

23. The column of claim 21 , wherein said separating agent is cellulose trisphenylcarbamate.

24. The column of claim 21 , wherein said phenyl group is ring- substituted with a group selected from among an alkyl group and a halogen group.

25. The column of claim 24 , wherein said phenyl group is ring- substituted with an alkyl group.

26. The column of claim 24 , wherein said phenyl group is ring- substituted with a halogen group.

27. The column of claim 26 , wherein said halogen group is chloro.

28. The column of claim 21 , wherein said porous carrier is silica.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.