Anticonvulsant enantiomeric amino acid derivatives

Abstract

The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.

What is claimed is:  
     
       1. A compound in the R configuration having the formula:                    
       wherein 
       Ar is phenyl which is unsubstituted or substituted with at least one halo group;  
       Q is lower alkoxy, and  
       Q 1  is methyl.  
     
     
       2. The compound according to  claim 1  which is substantially enantiopure. 
     
     
       3. The compound according to  claim 1  wherein Q is lower alkoxy containing 1-3 carbon atoms. 
     
     
       4. The compound according to  claim 3  wherein Q is methoxy. 
     
     
       5. The compound according to  claim 1  wherein Ar is unsubstituted phenyl. 
     
     
       6. The compound according to  claim 1  wherein halo is fluoro. 
     
     
       7. The compound according to  claim 1  wherein Q is alkoxy containing 1-3 carbon atoms and Ar is unsubstituted phenyl. 
     
     
       8. The compound according to  claim 1  which is (R)-N-Benzyl 2-Acetamido-3-methoxypropionamide. 
     
     
       9. The compound according to  claim 8  which contains at least 90% (w/w) R stereoisomer. 
     
     
       10. A therapeutic composition comprising an anticonvulsant effective amount of a compound according to any one of claims  1 - 9  and a pharmaceutical carrier therefor. 
     
     
       11. A method of treating central nervous system disorders in an animal comprising administering to said animal in need thereof an anticonvulsant effective amount of a compound according to any one of claims  1 - 9 . 
     
     
       12. The method according to  claim 11  wherein the animal is a mammal. 
     
     
       13. The method according to  claim 12  wherein the mammal is a human.