P
USRE39043EExpiredUtilityPatentIndex 71

Collagen production promoter composition

Assignee: SHISEIDO CO LTDPriority: Jan 17, 1997Filed: Nov 25, 2003Granted: Mar 28, 2006
Est. expiryJan 17, 2017(expired)· nominal 20-yr term from priority
Inventors:NAKAYAMA YASUKAZUKOJIMA NAO
A61Q 19/08A61K 36/49A61K 8/0212A61Q 17/04A61Q 1/02A61K 8/9789A61K 36/889A61Q 1/12
71
PatentIndex Score
10
Cited by
17
References
2
Claims

Abstract

A collagen production promoter composition according to the present invention containing an extract from a shoot of a tree belonging to the Fagaceae Fagus, particularly a young shoot, as an active component, which exhibits a superior effect of prevention of aging by promoting the production of collagen, which is one of the components of the extracellular matrix, and the activation of the excellular matrix and normalization of the skin tissue based on the promotion of production of collagen.

Claims

exact text as granted — not AI-modified
1. A method for promoting collagen production in a fibroblast of a subject comprising topically administering to said subject a collagen production promoter composition in an amount effective to promote collagen production in a fibroblast, wherein said composition comprises, as active components, (i) 0.0001 to 30.0% by weight, based upon the total weight of the composition, of an extract obtained by extracting a shoot of Fagus crenata with at least one solvent, wherein the advent is selected from the group consisting of water, ethanol, methanol, propanol, butanol, 1,3-butylene glycol and any mixtures thereof, and (ii) vitamin C a compound selected from the group consisting of L-ascorbic acid, L-ascorbate dipalmitate esters, L-ascorbate Monopalmitate esters, sodium L-ascorbate- 2 -sulfate, L-ascorbate phosphate esters, L-ascorbate stearate esters, L-ascorbate- 2 -glycoside or dipotassium DL-α-tocopherol-L-ascorbate phosphate diester or mixtures thereof in an amount effective for synergistic promotion of collagen production. 
     
     
       2. A method as claimed in claim in  1 , wherein the extract from a shoot of a Fagus crenata is contained in a range of 0.0001 to 10.0% by weight based upon the total weight of the composition.  3 .  A method as claimed in    claim 1   , wherein the compound is L - ascorbate -2- glycoside.

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