Methods of use for inhibiting bone loss and lowering serum cholesterol

Abstract

A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompassed by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.

1. A method of inhibiting post-menopausal bone loss or bone resorption in a post-menopausal woman in need of treatment to prevent or to treat post-menopausal osteoporosis comprising administering to a human said woman in need thereof of said treatment a compound of formula I 
                 
 
       or a pharmaceutically acceptable salt or solvate thereof, in an amount of about  50  to about  150    55  to  65  mg/day. 
     
     
       2. A method of  claim 1  wherein the human said woman has been diagnosed as suffering from post-menopausalosteoporosis. 
     
     
       3. A method of  claim 1  wherein the human is a post-menopausal female. 
     
     
       4. A method of  claim 1  wherein the human is a male. 
     
     
       5. A method of  claim 1  wherein the compound is administered prophylactically. 
     
     
       6. A method of  claim 1  wherein the compound of formula I is administered in an amount of about  60  to about  150  mg/day. 
     
     
       7. A method of  claim 1  wherein the compound of formula I is administered in an amount of 60 mg/day. 
     
     
       8. A method of  claim 1  wherein the compound of formula I is administered in an amount of 75 55 mg/day. 
     
     
       9. A method of  claim 1  wherein the compound of formula I is administered in an amount of 100 65 mg/day. 
     
     
       10. A method of  claim 1  wherein the compound of formula I is administered in an amount of  125  mg/day. 
     
     
       11. A method of  claim 1  wherein the compound of formula I is administered in an amount of  150  mg/day. 
     
     
       12. A method of  claim 1  wherein the compound is the which comprises administering a hydrochloride salt of a compound of formula I. 
     
     
       13. A method of  claim 12  wherein the hydrochloride salt is administered in an amount of  60  mg/day. 
     
     
       14. A method of preventing post-menopausal osteoporosis in a post-menopausal woman in need of treatment to prevent post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I 
                   
       in an amount of  60  mg/day. 
     
     
       15. A method of treating post-menopausal osteoporosis in a post-menopausal woman in need of treatment for post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I 
                   
       in an amount of  60  mg/day.